ENSG00000235162

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000443585 ENSG00000235162 HEK293_OSMI2_6hA HEK293_TMG_6hB C12orf75 protein_coding protein_coding 21.30595 12.13152 21.56722 1.894477 1.606875 0.8295604 16.502452 10.4914848 12.0275117 2.2703143 0.5416914 0.1969439 0.77949167 0.84570000 0.56840000 -0.27730000 1.286742e-01 1.811461e-11 FALSE FALSE
ENST00000548336 ENSG00000235162 HEK293_OSMI2_6hA HEK293_TMG_6hB C12orf75 protein_coding processed_transcript 21.30595 12.13152 21.56722 1.894477 1.606875 0.8295604 2.111792 0.0000000 8.0201775 0.0000000 2.2569680 9.6492881 0.09385417 0.00000000 0.35940000 0.35940000 1.811461e-11 1.811461e-11   FALSE
MSTRG.7925.3 ENSG00000235162 HEK293_OSMI2_6hA HEK293_TMG_6hB C12orf75 protein_coding   21.30595 12.13152 21.56722 1.894477 1.606875 0.8295604 1.220125 0.7475042 0.5661031 0.5736478 0.2413217 -0.3949269 0.05529167 0.08223333 0.02826667 -0.05396667 1.000000e+00 1.811461e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000235162 E001 0.1779838 0.0349242588 6.078917e-01   12 105235290 105235356 67 + 0.110 0.000 -8.749
ENSG00000235162 E002 0.0000000       12 105326970 105327063 94 +      
ENSG00000235162 E003 0.0000000       12 105330636 105330661 26 +      
ENSG00000235162 E004 0.4756169 0.0571373313 5.682630e-02   12 105330662 105330673 12 + 0.000 0.320 11.885
ENSG00000235162 E005 2.8012592 0.0913304712 1.149267e-01 3.073478e-01 12 105330674 105330690 17 + 0.432 0.726 1.343
ENSG00000235162 E006 7.0757206 0.0043110549 2.553659e-06 6.453157e-05 12 105330691 105330709 19 + 0.554 1.137 2.303
ENSG00000235162 E007 30.8363685 0.0016436753 2.112629e-12 2.057185e-10 12 105330710 105330852 143 + 1.239 1.696 1.574
ENSG00000235162 E008 24.8037484 0.0017350291 4.925678e-06 1.137158e-04 12 105330853 105330867 15 + 1.239 1.559 1.108
ENSG00000235162 E009 46.1157145 0.0022513360 4.792258e-04 5.487765e-03 12 105330868 105330937 70 + 1.576 1.766 0.643
ENSG00000235162 E010 44.6734494 0.0054972878 9.789911e-02 2.781118e-01 12 105348602 105348626 25 + 1.608 1.713 0.356
ENSG00000235162 E011 0.0000000       12 105353509 105353586 78 +      
ENSG00000235162 E012 70.7639994 0.0013956677 4.231427e-01 6.459501e-01 12 105365807 105365842 36 + 1.838 1.873 0.117
ENSG00000235162 E013 2.1132346 0.0523889756 8.623043e-01 9.315820e-01 12 105365843 105366464 622 + 0.477 0.504 0.132
ENSG00000235162 E014 140.3316466 0.0003146383 4.313436e-01 6.522019e-01 12 105366617 105366696 80 + 2.157 2.134 -0.077
ENSG00000235162 E015 97.9975548 0.0005314639 7.547847e-02 2.358137e-01 12 105367472 105367476 5 + 2.020 1.956 -0.213
ENSG00000235162 E016 135.8325497 0.0005073375 1.380015e-01 3.444599e-01 12 105367477 105367509 33 + 2.152 2.107 -0.150
ENSG00000235162 E017 376.8077180 0.0005019941 3.159353e-07 1.032982e-05 12 105370634 105371518 885 + 2.609 2.526 -0.274
ENSG00000235162 E018 1.3915740 0.0133993136 4.303397e-02 1.626493e-01 12 105395632 105396097 466 + 0.197 0.549 2.148