ENSG00000234545

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000415397 ENSG00000234545 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM133B protein_coding nonsense_mediated_decay 30.44428 10.41893 49.67298 0.3960875 2.963817 2.252161 6.805681 2.7246374 12.598526 0.82797544 1.0733562 2.204978 0.23365417 0.26793333 0.2533667 -0.01456667 1.000000000 0.004915426 TRUE FALSE
ENST00000445716 ENSG00000234545 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM133B protein_coding protein_coding 30.44428 10.41893 49.67298 0.3960875 2.963817 2.252161 15.716948 6.4635500 22.616340 0.93952806 0.6077451 1.805374 0.56727083 0.61543333 0.4579333 -0.15750000 0.417935211 0.004915426 FALSE TRUE
ENST00000481407 ENSG00000234545 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM133B protein_coding retained_intron 30.44428 10.41893 49.67298 0.3960875 2.963817 2.252161 2.102854 0.4889725 4.191773 0.07302110 0.4553003 3.073966 0.05889167 0.04653333 0.0839000 0.03736667 0.177060306 0.004915426 TRUE FALSE
MSTRG.30217.5 ENSG00000234545 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM133B protein_coding   30.44428 10.41893 49.67298 0.3960875 2.963817 2.252161 3.300239 0.1846919 7.438636 0.09538564 1.4265648 5.257711 0.07485417 0.01743333 0.1486667 0.13123333 0.004915426 0.004915426 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000234545 E001 0.9528494 0.022674430 0.59964161   7 92560758 92560792 35 - 0.221 0.354 0.927
ENSG00000234545 E002 18.0940889 0.423303741 0.32189892 0.56136619 7 92560793 92561136 344 - 1.149 1.349 0.702
ENSG00000234545 E003 7.5527265 0.187375576 0.17167104 0.39276926 7 92561137 92561215 79 - 0.775 1.095 1.205
ENSG00000234545 E004 49.5623180 0.721544255 0.23902334 0.47549593 7 92561216 92561749 534 - 1.529 1.848 1.083
ENSG00000234545 E005 38.6124183 0.635917829 0.29130903 0.53188305 7 92561750 92562050 301 - 1.448 1.696 0.847
ENSG00000234545 E006 116.4525452 1.285829741 0.46835394 0.67895327 7 92562051 92562281 231 - 1.935 2.127 0.643
ENSG00000234545 E007 79.9226308 0.861630867 0.27234999 0.51223473 7 92562282 92562368 87 - 1.733 2.051 1.072
ENSG00000234545 E008 14.9653135 0.665754982 0.80666941 0.90012042 7 92563852 92563952 101 - 1.090 1.228 0.494
ENSG00000234545 E009 11.9870796 0.374602373 0.55618407 0.74063460 7 92565508 92566009 502 - 1.002 1.139 0.497
ENSG00000234545 E010 5.3312738 0.160397778 0.46164743 0.67429045 7 92566010 92566013 4 - 0.687 0.869 0.727
ENSG00000234545 E011 60.4818328 0.741187378 0.17783856 0.40089129 7 92566014 92566049 36 - 1.584 1.980 1.340
ENSG00000234545 E012 59.3465886 0.746461803 0.20790573 0.43929874 7 92566050 92566061 12 - 1.588 1.953 1.235
ENSG00000234545 E013 4.2498189 0.070183138 0.16328830 0.38161514 7 92569542 92569822 281 - 0.579 0.862 1.167
ENSG00000234545 E014 89.9950204 1.171573792 0.40545330 0.63266347 7 92569823 92569915 93 - 1.810 2.051 0.810
ENSG00000234545 E015 105.3115629 0.005539791 0.81208481 0.90345913 7 92575771 92575821 51 - 1.929 2.007 0.265
ENSG00000234545 E016 0.1426347 0.031449147 1.00000000   7 92575822 92575854 33 - 0.066 0.000 -7.871
ENSG00000234545 E017 153.8565314 0.002487228 0.08215998 0.24901902 7 92577103 92577195 93 - 2.104 2.113 0.030
ENSG00000234545 E018 0.4632531 0.033361879 0.48218422   7 92577196 92577394 199 - 0.175 0.000 -9.456
ENSG00000234545 E019 102.8432992 0.020606128 0.13251987 0.33578409 7 92577655 92577676 22 - 1.937 1.909 -0.095
ENSG00000234545 E020 100.5266355 0.031646036 0.21708405 0.44996234 7 92577677 92577717 41 - 1.925 1.910 -0.053
ENSG00000234545 E021 26.5210663 0.005669626 0.01352867 0.07246884 7 92577718 92578149 432 - 1.386 1.239 -0.515
ENSG00000234545 E022 87.1202380 0.034263355 0.55483684 0.73966196 7 92578150 92578182 33 - 1.852 1.893 0.141
ENSG00000234545 E023 148.2436951 0.026132846 0.05858651 0.19961751 7 92578319 92578393 75 - 2.100 2.040 -0.201
ENSG00000234545 E024 0.0000000       7 92579155 92579316 162 -      
ENSG00000234545 E025 157.2432539 0.029230269 0.05892126 0.20033206 7 92579317 92579395 79 - 2.126 2.061 -0.220
ENSG00000234545 E026 171.5053088 0.028086608 0.01979574 0.09519130 7 92581506 92581603 98 - 2.170 2.071 -0.332
ENSG00000234545 E027 0.4820342 0.022089581 0.47870074   7 92581604 92581806 203 - 0.175 0.000 -9.458
ENSG00000234545 E028 3.3323552 0.008786707 0.53275046 0.72404691 7 92585298 92585396 99 - 0.599 0.545 -0.246
ENSG00000234545 E029 0.5963342 0.021768165 1.00000000   7 92589860 92589875 16 - 0.175 0.211 0.337
ENSG00000234545 E030 0.7555370 0.017725286 0.86493635   7 92589876 92590267 392 - 0.221 0.212 -0.078
ENSG00000234545 E031 138.0981099 0.031595781 0.02551175 0.11379035 7 92590268 92590393 126 - 2.078 1.969 -0.368