ENSG00000234327

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000413077 ENSG00000234327 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF232-AS1 lncRNA lncRNA 11.64336 12.10172 6.117977 1.712163 0.5555832 -0.9829211 8.7468006 9.1120482 3.7853092 1.54555514 0.2668269 -1.265140 0.72442500 0.74573333 0.6211000 -0.1246333 0.25014053 0.01285976   FALSE
ENST00000623522 ENSG00000234327 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF232-AS1 lncRNA TEC 11.64336 12.10172 6.117977 1.712163 0.5555832 -0.9829211 0.5299101 0.2689626 0.9129369 0.07826162 0.1634337 1.726160 0.06431667 0.02536667 0.1533333 0.1279667 0.01285976 0.01285976   FALSE
ENST00000665679 ENSG00000234327 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF232-AS1 lncRNA lncRNA 11.64336 12.10172 6.117977 1.712163 0.5555832 -0.9829211 2.1667109 2.5671261 1.0842474 0.23951430 0.1918350 -1.235824 0.18780417 0.21603333 0.1747333 -0.0413000 0.74299797 0.01285976 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000234327 E001 0.1779838 0.213114408 1.653948e-01   17 5111468 5111640 173 + 0.189 0.000 -9.818
ENSG00000234327 E002 0.8591680 0.161066637 5.338007e-01   17 5111914 5111925 12 + 0.319 0.200 -0.894
ENSG00000234327 E003 24.7719996 0.002054984 5.665478e-01 0.7476732102 17 5111926 5111956 31 + 1.322 1.378 0.194
ENSG00000234327 E004 122.7356246 0.530505034 2.206404e-01 0.4542180822 17 5111957 5112101 145 + 1.882 2.078 0.658
ENSG00000234327 E005 78.9194525 0.348371866 1.889893e-01 0.4156971893 17 5112102 5112118 17 + 1.688 1.889 0.681
ENSG00000234327 E006 2.1104948 0.343791440 1.116608e-02 0.0630706848 17 5113359 5113385 27 + 0.858 0.143 -3.990
ENSG00000234327 E007 124.6618911 0.000634280 7.522446e-02 0.2352684841 17 5113386 5113452 67 + 1.990 2.063 0.244
ENSG00000234327 E008 19.2179868 0.173460940 5.047905e-05 0.0008387801 17 5113453 5113979 527 + 1.674 0.884 -2.795
ENSG00000234327 E009 8.7622570 0.220168435 3.400098e-03 0.0257579978 17 5113980 5114157 178 + 1.309 0.655 -2.458
ENSG00000234327 E010 128.1327962 0.013418738 1.357292e-01 0.3409251302 17 5114158 5115004 847 + 2.088 2.043 -0.153