ENSG00000231064

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422665 ENSG00000231064 HEK293_OSMI2_6hA HEK293_TMG_6hB THBS3-AS1 lncRNA lncRNA 0.7615145 1.23578 0.9006048 0.2958227 0.4693235 -0.4521528 0.02169360 0.010754425 0.1114581 0.010754425 0.11145810 2.5489678 0.02180833 0.00960000 0.06166667 0.052066667 0.76523244 0.01086722 FALSE FALSE
ENST00000430312 ENSG00000231064 HEK293_OSMI2_6hA HEK293_TMG_6hB THBS3-AS1 lncRNA lncRNA 0.7615145 1.23578 0.9006048 0.2958227 0.4693235 -0.4521528 0.03187877 0.004293135 0.1387882 0.004293135 0.12289392 3.3798655 0.02721250 0.00240000 0.08730000 0.084900000 0.38013885 0.01086722 FALSE FALSE
ENST00000436772 ENSG00000231064 HEK293_OSMI2_6hA HEK293_TMG_6hB THBS3-AS1 lncRNA lncRNA 0.7615145 1.23578 0.9006048 0.2958227 0.4693235 -0.4521528 0.02617944 0.000000000 0.1251039 0.000000000 0.12510388 3.7559972 0.04701667 0.00000000 0.06920000 0.069200000 0.65283976 0.01086722 TRUE FALSE
ENST00000447623 ENSG00000231064 HEK293_OSMI2_6hA HEK293_TMG_6hB THBS3-AS1 lncRNA lncRNA 0.7615145 1.23578 0.9006048 0.2958227 0.4693235 -0.4521528 0.03349738 0.000000000 0.0000000 0.000000000 0.00000000 0.0000000 0.05574583 0.00000000 0.00000000 0.000000000   0.01086722 TRUE FALSE
ENST00000454348 ENSG00000231064 HEK293_OSMI2_6hA HEK293_TMG_6hB THBS3-AS1 lncRNA lncRNA 0.7615145 1.23578 0.9006048 0.2958227 0.4693235 -0.4521528 0.31284653 0.619262624 0.3651366 0.196726389 0.13586637 -0.7462463 0.37888750 0.47996667 0.48160000 0.001633333 1.00000000 0.01086722   FALSE
ENST00000687157 ENSG00000231064 HEK293_OSMI2_6hA HEK293_TMG_6hB THBS3-AS1 lncRNA lncRNA 0.7615145 1.23578 0.9006048 0.2958227 0.4693235 -0.4521528 0.01710115 0.074931090 0.0000000 0.055990026 0.00000000 -3.0862928 0.02630417 0.07193333 0.00000000 -0.071933333 0.67552947 0.01086722 TRUE FALSE
ENST00000690090 ENSG00000231064 HEK293_OSMI2_6hA HEK293_TMG_6hB THBS3-AS1 lncRNA lncRNA 0.7615145 1.23578 0.9006048 0.2958227 0.4693235 -0.4521528 0.10164384 0.225443099 0.0000000 0.096576490 0.00000000 -4.5573065 0.11730417 0.16780000 0.00000000 -0.167800000 0.01086722 0.01086722 TRUE FALSE
MSTRG.2304.9 ENSG00000231064 HEK293_OSMI2_6hA HEK293_TMG_6hB THBS3-AS1 lncRNA   0.7615145 1.23578 0.9006048 0.2958227 0.4693235 -0.4521528 0.18366013 0.243438698 0.1448857 0.092631812 0.03999025 -0.7104329 0.27002500 0.22223333 0.23636667 0.014133333 1.00000000 0.01086722   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000231064 E001 0.1723744 0.031518888 1.000000000   1 155194997 155194997 1 + 0.000 0.072 10.179
ENSG00000231064 E002 0.1723744 0.031518888 1.000000000   1 155194998 155195000 3 + 0.000 0.072 10.180
ENSG00000231064 E003 0.3447487 0.049864704 0.676728841   1 155195001 155195089 89 + 0.000 0.134 11.182
ENSG00000231064 E004 0.3447487 0.049864704 0.676728841   1 155195090 155195176 87 + 0.000 0.134 11.182
ENSG00000231064 E005 0.6839606 0.020217854 1.000000000   1 155195177 155195306 130 + 0.198 0.188 -0.092
ENSG00000231064 E006 1.0287093 0.016029685 0.533563667   1 155195307 155195368 62 + 0.198 0.280 0.646
ENSG00000231064 E007 0.6479912 0.021768165 0.245357096   1 155195369 155195372 4 + 0.000 0.236 12.179
ENSG00000231064 E008 0.7844689 0.019387492 0.710206110   1 155196851 155196898 48 + 0.198 0.236 0.320
ENSG00000231064 E009 2.4580176 0.023568033 0.003521314 0.02647072 1 155196899 155197017 119 + 0.000 0.569 14.086
ENSG00000231064 E010 4.1223722 0.209841542 0.889770477 0.94657821 1 155197018 155197789 772 + 0.647 0.667 0.086
ENSG00000231064 E011 2.4874676 0.050519899 0.171286168 0.39221103 1 155197835 155197964 130 + 0.333 0.545 1.121
ENSG00000231064 E012 3.7671946 0.097359657 0.357605218 0.59378725 1 155198160 155198402 243 + 0.517 0.650 0.599
ENSG00000231064 E013 6.9174676 0.310983788 0.215776936 0.44836941 1 155198403 155198618 216 + 0.589 0.886 1.217
ENSG00000231064 E014 3.4520133 0.008935971 0.940127501 0.97231016 1 155200172 155200237 66 + 0.650 0.569 -0.355
ENSG00000231064 E015 3.6464927 0.009132097 0.595168188 0.76713257 1 155200238 155200311 74 + 0.589 0.610 0.090
ENSG00000231064 E016 1.9439264 0.044960833 0.565049281 0.74681443 1 155200312 155200572 261 + 0.520 0.358 -0.857
ENSG00000231064 E017 2.5704800 0.009994788 0.138437410 0.34518209 1 155200700 155200801 102 + 0.333 0.547 1.131
ENSG00000231064 E018 1.2967903 0.021891199 0.891257118   1 155200802 155200826 25 + 0.333 0.319 -0.089
ENSG00000231064 E019 0.3503582 0.027442404 0.480840511   1 155201719 155201885 167 + 0.198 0.072 -1.677
ENSG00000231064 E020 0.1614157 0.095901564 0.185160067   1 155202033 155202102 70 + 0.198 0.000 -13.568
ENSG00000231064 E021 0.6376527 0.027409506 0.352476940   1 155202326 155202426 101 + 0.333 0.134 -1.675
ENSG00000231064 E022 1.2129700 0.029422118 0.050131970   1 155203123 155203271 149 + 0.000 0.387 13.172
ENSG00000231064 E023 8.9692048 0.523836846 0.093792782 0.27078910 1 155205035 155208694 3660 + 1.395 0.543 -3.256