ENSG00000230124

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367595 ENSG00000230124 HEK293_OSMI2_6hA HEK293_TMG_6hB ACBD6 protein_coding protein_coding 65.91152 72.68569 49.10831 9.998672 1.162227 -0.5656091 39.73698 47.43236 28.22304 11.058474 1.3604470 -0.74879109 0.6083667 0.6318 0.5740333 -0.05776667 0.85784769 0.01758488 FALSE  
ENST00000496993 ENSG00000230124 HEK293_OSMI2_6hA HEK293_TMG_6hB ACBD6 protein_coding processed_transcript 65.91152 72.68569 49.10831 9.998672 1.162227 -0.5656091 17.26060 14.18888 14.30649 2.696471 0.1867999 0.01190074 0.2381083 0.1920 0.2914667 0.09946667 0.01758488 0.01758488 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000230124 E001 0.8812730 0.268516408 5.872759e-01   1 180266170 180266226 57 - 0.163 0.289 1.051
ENSG00000230124 E002 0.6479912 0.247326792 2.126189e-01   1 180269458 180269652 195 - 0.000 0.283 12.872
ENSG00000230124 E003 61.9772940 0.057078189 6.031981e-01 0.772346663 1 180269653 180270116 464 - 1.710 1.801 0.308
ENSG00000230124 E004 29.4396441 0.097607817 1.120443e-01 0.302497520 1 180270117 180270187 71 - 1.229 1.536 1.065
ENSG00000230124 E005 19.6208206 0.106213212 1.649688e-01 0.383941424 1 180270188 180270203 16 - 1.073 1.365 1.031
ENSG00000230124 E006 30.0949960 0.120219115 5.225484e-01 0.716726132 1 180270204 180270286 83 - 1.342 1.516 0.600
ENSG00000230124 E007 17.6029416 0.109717279 8.852302e-01 0.944079876 1 180270287 180270309 23 - 1.229 1.251 0.080
ENSG00000230124 E008 23.8601354 0.118609776 8.350481e-01 0.916543612 1 180270310 180270379 70 - 1.303 1.400 0.335
ENSG00000230124 E009 18.4204588 0.124561734 5.999989e-01 0.770213236 1 180270380 180270423 44 - 1.164 1.305 0.496
ENSG00000230124 E010 120.7706046 0.078453579 1.507599e-01 0.363377722 1 180270424 180271971 1548 - 1.879 2.126 0.827
ENSG00000230124 E011 8.8301521 0.047596660 5.422100e-01 0.730640789 1 180272502 180272517 16 - 0.893 0.993 0.373
ENSG00000230124 E012 10.0997957 0.027075669 7.210932e-01 0.848850845 1 180272518 180272535 18 - 0.984 1.036 0.190
ENSG00000230124 E013 16.9396045 0.048576791 6.746930e-01 0.819318341 1 180272536 180272601 66 - 1.180 1.252 0.254
ENSG00000230124 E014 11.1612112 0.056513610 4.000023e-01 0.628242760 1 180272602 180272611 10 - 0.963 1.107 0.528
ENSG00000230124 E015 11.9690254 0.053508562 4.419030e-01 0.660029031 1 180272612 180272612 1 - 1.003 1.130 0.461
ENSG00000230124 E016 12.8548103 0.071227765 6.586714e-01 0.809153576 1 180272613 180272617 5 - 1.058 1.149 0.327
ENSG00000230124 E017 22.3735678 0.111720502 9.096651e-01 0.956926692 1 180272618 180272692 75 - 1.301 1.366 0.228
ENSG00000230124 E018 48.1883396 0.092206762 8.590478e-01 0.929844387 1 180272693 180273337 645 - 1.625 1.684 0.202
ENSG00000230124 E019 17.1030432 0.167181866 7.537333e-01 0.868971550 1 180273338 180273398 61 - 1.250 1.228 -0.075
ENSG00000230124 E020 9.9997420 0.222814278 8.647392e-01 0.932982837 1 180273399 180273511 113 - 0.995 1.027 0.120
ENSG00000230124 E021 24.2803764 0.294098717 4.313200e-01 0.652183740 1 180273614 180273936 323 - 1.415 1.356 -0.204
ENSG00000230124 E022 33.2659298 0.145927416 9.422314e-01 0.973389027 1 180273937 180274112 176 - 1.469 1.527 0.199
ENSG00000230124 E023 13.3663349 0.155490851 2.734183e-01 0.513267208 1 180274113 180274485 373 - 0.938 1.203 0.961
ENSG00000230124 E024 6.7400830 0.426834248 4.984429e-01 0.699741761 1 180274486 180274650 165 - 0.658 0.945 1.135
ENSG00000230124 E025 18.2934681 0.524647780 6.476867e-01 0.801983992 1 180274651 180274754 104 - 1.164 1.302 0.488
ENSG00000230124 E026 21.0483112 0.459158282 4.802946e-01 0.687268842 1 180274755 180274984 230 - 1.174 1.375 0.707
ENSG00000230124 E027 11.1226557 0.282467939 5.820796e-01 0.758428196 1 180274985 180275064 80 - 0.988 1.093 0.384
ENSG00000230124 E028 12.3126243 0.312489304 4.507909e-01 0.666231539 1 180275065 180275205 141 - 0.977 1.149 0.626
ENSG00000230124 E029 21.0680248 0.390835905 3.862173e-01 0.617466993 1 180275206 180275379 174 - 1.163 1.379 0.758
ENSG00000230124 E030 10.5628881 0.189722768 2.457472e-01 0.483278581 1 180275380 180275395 16 - 0.856 1.109 0.938
ENSG00000230124 E031 9.4979516 0.129435222 9.226664e-02 0.267942300 1 180275396 180275412 17 - 0.738 1.085 1.319
ENSG00000230124 E032 31.8880528 0.481766286 2.756625e-01 0.515748819 1 180275413 180276224 812 - 1.243 1.576 1.150
ENSG00000230124 E033 20.8093104 0.609894150 6.713461e-01 0.817188935 1 180277782 180278815 1034 - 1.190 1.364 0.610
ENSG00000230124 E034 4.2357127 0.076768237 8.639505e-02 0.257216163 1 180281229 180281305 77 - 0.871 0.573 -1.227
ENSG00000230124 E035 11.3538623 0.056487053 8.651156e-01 0.933219901 1 180281306 180281386 81 - 1.076 1.063 -0.044
ENSG00000230124 E036 1.8559401 0.290399662 5.746749e-02 0.197101852 1 180284216 180284248 33 - 0.674 0.230 -2.412
ENSG00000230124 E037 0.3228314 0.396673209 1.334948e-01   1 180286381 180286431 51 - 0.282 0.000 -13.893
ENSG00000230124 E038 2.7735129 0.008101828 4.074488e-05 0.000699143 1 180286983 180287256 274 - 0.868 0.227 -3.214
ENSG00000230124 E039 0.5173834 0.047210888 2.153363e-02   1 180287257 180287275 19 - 0.375 0.000 -14.478
ENSG00000230124 E040 9.7737217 0.063781312 8.186147e-01 0.907232935 1 180287276 180287402 127 - 1.023 0.999 -0.086
ENSG00000230124 E041 0.1723744 0.035748610 1.000000e+00   1 180287403 180287406 4 - 0.000 0.090 10.871
ENSG00000230124 E042 54.5851204 0.001792721 7.197708e-01 0.848050703 1 180288230 180288269 40 - 1.730 1.721 -0.033
ENSG00000230124 E043 469.9103367 0.005616030 6.991602e-01 0.835057457 1 180288270 180288517 248 - 2.648 2.646 -0.008
ENSG00000230124 E044 0.1426347 0.031791458 2.440831e-01   1 180300429 180300455 27 - 0.163 0.000 -12.886
ENSG00000230124 E045 357.9237506 0.007251026 3.993159e-01 0.627700713 1 180314692 180314722 31 - 2.545 2.521 -0.078
ENSG00000230124 E046 1.3078216 0.013696863 7.941370e-01   1 180326411 180326562 152 - 0.374 0.331 -0.255
ENSG00000230124 E047 534.8698714 0.006939100 1.968203e-01 0.425574436 1 180397516 180397605 90 - 2.729 2.688 -0.134
ENSG00000230124 E048 571.0727733 0.005762656 1.884913e-01 0.415058749 1 180413366 180413471 106 - 2.755 2.718 -0.122
ENSG00000230124 E049 477.5963064 0.005426365 2.608928e-01 0.499881039 1 180430180 180430262 83 - 2.673 2.643 -0.101
ENSG00000230124 E050 0.4950181 0.021768165 1.000000e+00   1 180452325 180452393 69 - 0.163 0.164 0.009
ENSG00000230124 E051 450.0379738 0.007255714 3.543055e-01 0.591122940 1 180492269 180492365 97 - 2.645 2.618 -0.088
ENSG00000230124 E052 330.9667687 0.011055519 6.037281e-01 0.772636168 1 180495461 180495525 65 - 2.502 2.489 -0.043
ENSG00000230124 E053 951.9970925 0.014511127 9.607271e-01 0.982261028 1 180502045 180503185 1141 - 2.941 2.958 0.054