ENSG00000228630

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000424518 ENSG00000228630 HEK293_OSMI2_6hA HEK293_TMG_6hB HOTAIR lncRNA lncRNA 3.191942 3.884117 3.703647 0.1339276 0.1594084 -0.0684595 1.4658287 1.8082930 1.4302023 0.09753767 0.13233977 -0.33631318 0.47350833 0.46636667 0.38733333 -0.07903333 7.305272e-01 6.217848e-07 FALSE FALSE
ENST00000425595 ENSG00000228630 HEK293_OSMI2_6hA HEK293_TMG_6hB HOTAIR lncRNA lncRNA 3.191942 3.884117 3.703647 0.1339276 0.1594084 -0.0684595 0.6457022 0.7800488 0.7114520 0.20823588 0.35789438 -0.13103831 0.19116250 0.20253333 0.18610000 -0.01643333 9.469760e-01 6.217848e-07   FALSE
ENST00000439545 ENSG00000228630 HEK293_OSMI2_6hA HEK293_TMG_6hB HOTAIR lncRNA lncRNA 3.191942 3.884117 3.703647 0.1339276 0.1594084 -0.0684595 0.2106122 0.3979722 0.4134066 0.03281959 0.05527772 0.05357297 0.06206250 0.10246667 0.11216667 0.00970000 9.762563e-01 6.217848e-07   FALSE
MSTRG.7370.10 ENSG00000228630 HEK293_OSMI2_6hA HEK293_TMG_6hB HOTAIR lncRNA   3.191942 3.884117 3.703647 0.1339276 0.1594084 -0.0684595 0.2001054 0.5443448 0.0000000 0.07858838 0.00000000 -5.79271160 0.06198333 0.14133333 0.00000000 -0.14133333 6.217848e-07 6.217848e-07   FALSE
MSTRG.7370.11 ENSG00000228630 HEK293_OSMI2_6hA HEK293_TMG_6hB HOTAIR lncRNA   3.191942 3.884117 3.703647 0.1339276 0.1594084 -0.0684595 0.1817383 0.1612878 0.2368646 0.03984184 0.12468599 0.52729809 0.05653750 0.04096667 0.06156667 0.02060000 9.819253e-01 6.217848e-07   FALSE
MSTRG.7370.4 ENSG00000228630 HEK293_OSMI2_6hA HEK293_TMG_6hB HOTAIR lncRNA   3.191942 3.884117 3.703647 0.1339276 0.1594084 -0.0684595 0.1550978 0.1880711 0.3221511 0.18807112 0.32215106 0.74582097 0.05035000 0.04530000 0.09286667 0.04756667 1.000000e+00 6.217848e-07   FALSE
MSTRG.7370.7 ENSG00000228630 HEK293_OSMI2_6hA HEK293_TMG_6hB HOTAIR lncRNA   3.191942 3.884117 3.703647 0.1339276 0.1594084 -0.0684595 0.2169646 0.0000000 0.5269083 0.00000000 0.26982740 5.74660375 0.06878750 0.00000000 0.14296667 0.14296667 2.664069e-01 6.217848e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000228630 E001 24.4960677 0.031825043 0.545741270 0.73325226 12 53962308 53962724 417 - 1.360 1.424 0.221
ENSG00000228630 E002 11.7829071 0.002758363 0.425537682 0.64769292 12 53962725 53962753 29 - 1.146 1.066 -0.289
ENSG00000228630 E003 21.2838137 0.002527972 0.786515024 0.88842408 12 53962754 53962889 136 - 1.335 1.352 0.060
ENSG00000228630 E004 58.9891035 0.001409162 0.002098229 0.01772509 12 53962890 53963743 854 - 1.688 1.821 0.448
ENSG00000228630 E005 7.1335158 0.037759358 0.814488202 0.90493317 12 53963744 53963748 5 - 0.874 0.924 0.191
ENSG00000228630 E006 8.2224675 0.004419772 0.707949412 0.84051268 12 53963749 53963801 53 - 0.936 0.976 0.146
ENSG00000228630 E007 9.4669179 0.004037039 0.928003290 0.96603062 12 53963802 53963819 18 - 1.007 1.012 0.019
ENSG00000228630 E008 13.2923451 0.003117451 0.893607423 0.94849115 12 53963820 53963900 81 - 1.157 1.141 -0.059
ENSG00000228630 E009 7.2799796 0.011049234 0.959515007 0.98166754 12 53963901 53963932 32 - 0.916 0.908 -0.030
ENSG00000228630 E010 5.1088582 0.006010292 0.889376936 0.94639031 12 53963933 53963933 1 - 0.775 0.791 0.061
ENSG00000228630 E011 6.0201312 0.005371986 0.863770785 0.93249599 12 53963934 53963935 2 - 0.852 0.828 -0.094
ENSG00000228630 E012 20.4702777 0.001849825 0.891262680 0.94724834 12 53963936 53964084 149 - 1.335 1.320 -0.052
ENSG00000228630 E013 12.0130500 0.002814149 0.297319875 0.53781643 12 53964085 53964124 40 - 1.169 1.066 -0.370
ENSG00000228630 E014 2.1643442 0.038325057 0.852159375 0.92627892 12 53964231 53964236 6 - 0.465 0.503 0.190
ENSG00000228630 E015 3.6583318 0.008282465 0.612034460 0.77821433 12 53964237 53964283 47 - 0.608 0.683 0.321
ENSG00000228630 E016 12.1862056 0.219100220 0.629744547 0.79032820 12 53965964 53966059 96 - 1.108 1.121 0.046
ENSG00000228630 E017 4.8457777 0.213846178 0.485298158 0.69073783 12 53966060 53966083 24 - 0.890 0.653 -0.950
ENSG00000228630 E018 4.1443710 0.283520507 0.822003291 0.90909429 12 53966084 53966087 4 - 0.801 0.628 -0.711
ENSG00000228630 E019 13.2517412 0.293029331 0.627471038 0.78887608 12 53966276 53966377 102 - 1.161 1.140 -0.075
ENSG00000228630 E020 0.9518539 0.015447310 0.190102062   12 53966608 53966630 23 - 0.140 0.373 1.835
ENSG00000228630 E021 10.8524365 0.112869274 0.460855304 0.67376210 12 53967269 53967394 126 - 1.163 1.000 -0.590
ENSG00000228630 E022 1.3381088 0.071988522 0.096871704   12 53968201 53968280 80 - 0.140 0.466 2.336
ENSG00000228630 E023 2.6468084 0.153618935 0.862419603 0.93166509 12 53968384 53968616 233 - 0.558 0.572 0.065
ENSG00000228630 E024 14.3341511 0.002366603 0.083208530 0.25119498 12 53968617 53968749 133 - 1.269 1.114 -0.550
ENSG00000228630 E025 6.5835397 0.004221673 0.016212530 0.08257139 12 53968750 53968756 7 - 1.023 0.729 -1.129
ENSG00000228630 E026 3.6008776 0.007073302 0.923051912 0.96381260 12 53968757 53968914 158 - 0.647 0.657 0.044
ENSG00000228630 E027 3.1723740 0.018651892 0.810165698 0.90230763 12 53972534 53972657 124 - 0.646 0.602 -0.190
ENSG00000228630 E028 0.7616940 0.026983986 0.090241799   12 53972658 53972682 25 - 0.402 0.105 -2.482
ENSG00000228630 E029 2.5725730 0.134389079 0.337611051 0.57600235 12 53973055 53973079 25 - 0.402 0.612 1.019
ENSG00000228630 E030 2.1127573 0.010724715 0.099812865 0.28141584 12 53974898 53975193 296 - 0.647 0.373 -1.336
ENSG00000228630 E031 0.3150090 0.025670200 0.810389819   12 53975194 53977522 2329 - 0.140 0.105 -0.485