ENSG00000228065

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000598092 ENSG00000228065 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 4.255483 2.973736 5.742361 0.236168 0.2764251 0.9470343 0.2002867 0.1309915 0.04659456 0.08944830 0.04659456 -1.31687323 0.05701667 0.04170000 0.008633333 -0.033066667 0.7293212495 4.02452e-05   FALSE
ENST00000601888 ENSG00000228065 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 4.255483 2.973736 5.742361 0.236168 0.2764251 0.9470343 0.3199237 0.2223785 0.39146702 0.03487816 0.05925706 0.78880462 0.07545833 0.07776667 0.067933333 -0.009833333 0.9732698157 4.02452e-05   FALSE
ENST00000657227 ENSG00000228065 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 4.255483 2.973736 5.742361 0.236168 0.2764251 0.9470343 0.4572573 0.3620944 0.94016242 0.18072552 0.11830952 1.35250539 0.09894167 0.11473333 0.166300000 0.051566667 0.7841236933 4.02452e-05   FALSE
MSTRG.4061.11 ENSG00000228065 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA   4.255483 2.973736 5.742361 0.236168 0.2764251 0.9470343 0.4422489 0.0000000 0.72944500 0.00000000 0.15869268 6.20837094 0.08208750 0.00000000 0.127700000 0.127700000 0.0000402452 4.02452e-05   FALSE
MSTRG.4061.16 ENSG00000228065 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA   4.255483 2.973736 5.742361 0.236168 0.2764251 0.9470343 0.2525187 0.1725294 0.14044176 0.10487302 0.14044176 -0.27892395 0.07339167 0.06466667 0.026033333 -0.038633333 0.7369865309 4.02452e-05 FALSE FALSE
MSTRG.4061.9 ENSG00000228065 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA   4.255483 2.973736 5.742361 0.236168 0.2764251 0.9470343 0.7133657 1.0806691 1.02298462 0.28796531 0.14885650 -0.07839473 0.18712500 0.35183333 0.178966667 -0.172866667 0.3387324784 4.02452e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000228065 E001 0.2027342 0.032241707 0.363364602   10 65570338 65570445 108 + 0.000 0.146 11.625
ENSG00000228065 E002 0.2027342 0.032241707 0.363364602   10 65570446 65570451 6 + 0.000 0.146 14.439
ENSG00000228065 E003 0.2027342 0.032241707 0.363364602   10 65570452 65570465 14 + 0.000 0.146 14.439
ENSG00000228065 E004 0.2027342 0.032241707 0.363364602   10 65570466 65570467 2 + 0.000 0.146 14.439
ENSG00000228065 E005 0.2027342 0.032241707 0.363364602   10 65570468 65570470 3 + 0.000 0.146 14.439
ENSG00000228065 E006 0.3453689 0.026460535 0.817534106   10 65570471 65570474 4 + 0.100 0.146 0.623
ENSG00000228065 E007 0.8156366 0.016754272 0.917583925   10 65570475 65570497 23 + 0.251 0.255 0.034
ENSG00000228065 E008 0.8156366 0.016754272 0.917583925   10 65570498 65570501 4 + 0.251 0.255 0.034
ENSG00000228065 E009 1.1306456 0.013714896 0.973465750   10 65570502 65570509 8 + 0.310 0.342 0.205
ENSG00000228065 E010 1.1306456 0.013714896 0.973465750   10 65570510 65570511 2 + 0.310 0.342 0.205
ENSG00000228065 E011 1.2732802 0.013380263 0.790343953   10 65570512 65570512 1 + 0.362 0.342 -0.116
ENSG00000228065 E012 1.6068826 0.011651425 0.626453034 0.78818556 10 65570513 65570515 3 + 0.362 0.477 0.621
ENSG00000228065 E013 1.6068826 0.011651425 0.626453034 0.78818556 10 65570516 65570517 2 + 0.362 0.477 0.621
ENSG00000228065 E014 1.6068826 0.011651425 0.626453034 0.78818556 10 65570518 65570519 2 + 0.362 0.477 0.621
ENSG00000228065 E015 1.6068826 0.011651425 0.626453034 0.78818556 10 65570520 65570521 2 + 0.362 0.477 0.621
ENSG00000228065 E016 1.8096168 0.011392644 0.419945133 0.64361513 10 65570522 65570522 1 + 0.362 0.532 0.885
ENSG00000228065 E017 1.8096168 0.011392644 0.419945133 0.64361513 10 65570523 65570526 4 + 0.362 0.532 0.885
ENSG00000228065 E018 4.5894590 0.008964300 0.939028035 0.97183001 10 65570527 65570528 2 + 0.713 0.764 0.210
ENSG00000228065 E019 5.6195963 0.034800093 0.943991616 0.97433410 10 65570529 65570534 6 + 0.791 0.825 0.134
ENSG00000228065 E020 6.1548355 0.014022248 0.756906614 0.87080924 10 65570535 65570535 1 + 0.810 0.893 0.324
ENSG00000228065 E021 6.7982853 0.005691842 0.827030095 0.91211136 10 65570536 65570537 2 + 0.875 0.892 0.067
ENSG00000228065 E022 6.9762691 0.004823196 0.727650309 0.85281894 10 65570538 65570539 2 + 0.890 0.892 0.009
ENSG00000228065 E023 7.2968876 0.004913014 0.554831091 0.73966196 10 65570540 65570545 6 + 0.918 0.892 -0.098
ENSG00000228065 E024 4.8063240 0.006412960 0.323858857 0.56316114 10 65570546 65570556 11 + 0.793 0.699 -0.383
ENSG00000228065 E025 15.1050460 0.002930221 0.007978429 0.04920765 10 65570557 65570759 203 + 1.266 1.072 -0.691
ENSG00000228065 E026 0.7254668 0.059348594 0.200243932   10 65570760 65570874 115 + 0.101 0.344 2.212
ENSG00000228065 E027 2.4386548 0.010162024 0.734966338 0.85722853 10 65570875 65571424 550 + 0.489 0.580 0.427
ENSG00000228065 E028 19.8684591 0.002695700 0.122292065 0.31944389 10 65571425 65571484 60 + 1.334 1.260 -0.256
ENSG00000228065 E029 19.9334272 0.002090019 0.177756426 0.40078504 10 65571485 65571567 83 + 1.334 1.278 -0.194
ENSG00000228065 E030 11.1596362 0.019946485 0.759991614 0.87254693 10 65571568 65571579 12 + 1.076 1.085 0.033
ENSG00000228065 E031 22.4379816 0.001781194 0.475157491 0.68366238 10 65572935 65573056 122 + 1.318 1.418 0.349
ENSG00000228065 E032 0.1723744 0.033869319 0.362982459   10 65573057 65573200 144 + 0.000 0.146 14.435
ENSG00000228065 E033 0.5255656 0.232017980 0.809011970   10 65579883 65579948 66 + 0.182 0.148 -0.361
ENSG00000228065 E034 0.5008152 0.043726524 0.146295209   10 65581612 65581673 62 + 0.251 0.000 -15.250
ENSG00000228065 E035 0.3228314 0.370709340 0.397206644   10 65581674 65582473 800 + 0.183 0.000 -14.612
ENSG00000228065 E036 27.5156699 0.011768893 0.478979296 0.68642786 10 65585485 65585567 83 + 1.445 1.444 -0.006
ENSG00000228065 E037 21.8233012 0.006107720 0.064616802 0.21303060 10 65585568 65585664 97 + 1.379 1.280 -0.343
ENSG00000228065 E038 27.7549398 0.004530950 0.241023907 0.47774487 10 65585665 65585802 138 + 1.456 1.426 -0.106
ENSG00000228065 E039 7.2763051 0.006263118 0.630158406 0.79048738 10 65585803 65586279 477 + 0.905 0.893 -0.046
ENSG00000228065 E040 19.4768142 0.002264532 0.841137516 0.92010523 10 65615636 65615725 90 + 1.289 1.322 0.115
ENSG00000228065 E041 12.3075385 0.002515274 0.473091380 0.68219833 10 65615726 65615732 7 + 1.122 1.100 -0.077
ENSG00000228065 E042 11.1002252 0.002658944 0.314447829 0.55467181 10 65615733 65615733 1 + 1.095 1.041 -0.196
ENSG00000228065 E043 10.9575906 0.002684097 0.362478156 0.59774944 10 65615734 65615736 3 + 1.086 1.041 -0.163
ENSG00000228065 E044 12.7363000 0.002525344 0.442170326 0.66020179 10 65615737 65615761 25 + 1.138 1.114 -0.089
ENSG00000228065 E045 2.4828218 0.231738810 0.178591215 0.40210409 10 65615762 65615989 228 + 0.620 0.346 -1.379
ENSG00000228065 E046 0.1614157 0.032321602 0.641945939   10 65615990 65616189 200 + 0.100 0.000 -13.848
ENSG00000228065 E047 1.7870793 0.010919068 0.833729380 0.91586569 10 65628013 65628903 891 + 0.409 0.477 0.357
ENSG00000228065 E048 0.1426347 0.031073262 0.642938116   10 65632080 65632828 749 + 0.100 0.000 -13.847
ENSG00000228065 E049 1.0949365 0.014264060 0.113177403   10 65637870 65638050 181 + 0.409 0.146 -1.968
ENSG00000228065 E050 0.3393995 0.027442404 0.297128352   10 65638051 65638413 363 + 0.182 0.000 -14.750
ENSG00000228065 E051 0.6434498 0.019718715 0.072878408   10 65641604 65642134 531 + 0.310 0.000 -15.605
ENSG00000228065 E052 3.5665400 0.066237390 0.922974395 0.96380696 10 65659795 65660839 1045 + 0.643 0.662 0.078
ENSG00000228065 E053 4.5760923 0.006362394 0.663209242 0.81188737 10 65670085 65670688 604 + 0.691 0.792 0.413
ENSG00000228065 E054 7.3088391 0.004841706 0.664350764 0.81259887 10 65670689 65670871 183 + 0.919 0.913 -0.021
ENSG00000228065 E055 16.9905718 0.002570798 0.100338937 0.28241613 10 65670872 65672311 1440 + 1.278 1.187 -0.319
ENSG00000228065 E056 3.7754803 0.216842479 0.926771245 0.96547602 10 65672312 65672549 238 + 0.648 0.700 0.218
ENSG00000228065 E057 1.6008406 0.339674263 0.537457218 0.72727749 10 65679352 65679408 57 + 0.307 0.535 1.240
ENSG00000228065 E058 0.9825891 0.430384927 0.871622439   10 65679409 65679412 4 + 0.249 0.348 0.663
ENSG00000228065 E059 8.3622237 0.126263250 0.396746678 0.62575889 10 65680960 65682189 1230 + 0.870 1.084 0.797
ENSG00000228065 E060 5.5519042 0.099228317 0.589676256 0.76349316 10 65682190 65683232 1043 + 0.737 0.893 0.613
ENSG00000228065 E061 1.7198950 0.012108348 0.430858018 0.65177703 10 65689503 65689507 5 + 0.451 0.343 -0.601
ENSG00000228065 E062 2.5357192 0.009743337 0.218031309 0.45107282 10 65689508 65689611 104 + 0.587 0.415 -0.838
ENSG00000228065 E063 0.0000000       10 65689612 65689726 115 +      
ENSG00000228065 E064 0.1426347 0.031073262 0.642938116   10 65691701 65692187 487 + 0.100 0.000 -13.847
ENSG00000228065 E065 0.0000000       10 65698089 65698102 14 +      
ENSG00000228065 E066 0.7577498 0.094163439 0.329961570   10 65698103 65698726 624 + 0.310 0.145 -1.388
ENSG00000228065 E067 0.3150090 0.027169750 0.816493680   10 65715658 65716559 902 + 0.100 0.146 0.622
ENSG00000228065 E068 0.8323924 0.017267182 0.298139348   10 65736897 65736962 66 + 0.310 0.146 -1.381
ENSG00000228065 E069 0.8136113 0.028644731 0.303920361   10 65736963 65736999 37 + 0.310 0.146 -1.380
ENSG00000228065 E070 0.0000000       10 65750828 65751248 421 +      
ENSG00000228065 E071 0.0000000       10 65765351 65765399 49 +      
ENSG00000228065 E072 0.9034506 0.313492318 0.508710271   10 65766478 65766541 64 + 0.185 0.350 1.221
ENSG00000228065 E073 1.4995245 0.166601059 0.081258148 0.24736076 10 65766556 65766623 68 + 0.181 0.585 2.457
ENSG00000228065 E074 5.6334172 0.037041753 0.002385219 0.01959297 10 65768393 65768462 70 + 0.555 1.053 1.992
ENSG00000228065 E075 0.1614157 0.032321602 0.641945939   10 65768463 65768835 373 + 0.100 0.000 -13.848
ENSG00000228065 E076 45.2765291 0.631563600 0.108695866 0.29692437 10 65779542 65781072 1531 + 1.397 1.881 1.650
ENSG00000228065 E077 0.3337900 0.026712036 0.818582383   10 65828434 65828538 105 + 0.100 0.146 0.620
ENSG00000228065 E078 0.3393995 0.027442404 0.297128352   10 65852506 65852609 104 + 0.182 0.000 -14.750
ENSG00000228065 E079 0.3206185 0.027442404 0.298283432   10 65877157 65877498 342 + 0.182 0.000 -14.749
ENSG00000228065 E080 1.1232712 0.015378759 0.011277923   10 65878643 65880289 1647 + 0.451 0.000 -16.260