ENSG00000226688

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000669283 ENSG00000226688 HEK293_OSMI2_6hA HEK293_TMG_6hB ENTPD1-AS1 lncRNA lncRNA 18.96159 10.8134 25.70697 1.255806 0.2798045 1.248567 7.5061636 4.674427 11.289974 0.7515253 0.46402730 1.270375 0.41417500 0.4282667 0.43966667 0.01140000 9.822264e-01 4.138804e-10 FALSE TRUE
ENST00000671323 ENSG00000226688 HEK293_OSMI2_6hA HEK293_TMG_6hB ENTPD1-AS1 lncRNA lncRNA 18.96159 10.8134 25.70697 1.255806 0.2798045 1.248567 2.3444763 1.192162 2.115634 0.1480083 1.10016878 0.822262 0.11525833 0.1111333 0.08143333 -0.02970000 8.703956e-01 4.138804e-10 FALSE TRUE
MSTRG.4429.24 ENSG00000226688 HEK293_OSMI2_6hA HEK293_TMG_6hB ENTPD1-AS1 lncRNA   18.96159 10.8134 25.70697 1.255806 0.2798045 1.248567 0.6307876 0.000000 1.449259 0.0000000 0.08884272 7.189092 0.02927083 0.0000000 0.05643333 0.05643333 4.138804e-10 4.138804e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000226688 E001 1.4949831 0.0497098925 0.55727152 0.74133059 10 95732976 95733750 775 - 0.431 0.324 -0.614
ENSG00000226688 E002 2.0953111 0.3408656090 1.00000000 1.00000000 10 95753206 95755361 2156 - 0.434 0.550 0.566
ENSG00000226688 E003 1.2980306 0.0136457158 0.71710299   10 95755362 95755864 503 - 0.329 0.393 0.380
ENSG00000226688 E004 1.1781211 0.2526185676 0.52084099   10 95755865 95756616 752 - 0.263 0.403 0.879
ENSG00000226688 E005 0.6494192 0.0193874923 0.45927338   10 95756617 95756714 98 - 0.267 0.136 -1.205
ENSG00000226688 E006 0.1426347 0.0726684183 0.55507587   10 95756715 95756719 5 - 0.108 0.000 -12.045
ENSG00000226688 E007 0.1426347 0.0726684183 0.55507587   10 95784944 95785025 82 - 0.108 0.000 -12.045
ENSG00000226688 E008 0.1614157 0.1488243024 0.55083050   10 95785026 95785245 220 - 0.108 0.000 -12.050
ENSG00000226688 E009 0.4929928 0.5178045752 0.59745951   10 95824094 95824694 601 - 0.195 0.137 -0.608
ENSG00000226688 E010 0.7263945 0.0485338323 0.14290887   10 95847302 95847391 90 - 0.108 0.391 2.363
ENSG00000226688 E011 1.7151454 0.2805874389 0.30422745 0.54480287 10 95847392 95847485 94 - 0.266 0.611 1.865
ENSG00000226688 E012 8.8051303 0.0254315113 0.31975783 0.55948810 10 95847486 95848785 1300 - 1.046 0.938 -0.399
ENSG00000226688 E013 18.7633600 0.3961815193 0.23105484 0.46640232 10 95860148 95861312 1165 - 1.354 1.198 -0.547
ENSG00000226688 E014 4.7412351 0.5145977945 0.26116664 0.50020264 10 95861313 95861526 214 - 0.841 0.625 -0.883
ENSG00000226688 E015 5.0177425 0.0061171198 0.08932493 0.26251498 10 95861527 95861669 143 - 0.875 0.634 -0.976
ENSG00000226688 E016 37.2243679 0.0125132500 0.16642892 0.38577554 10 95871507 95871816 310 - 1.643 1.512 -0.447
ENSG00000226688 E017 35.3806081 0.0011270753 0.01907417 0.09273114 10 95871817 95872113 297 - 1.632 1.483 -0.508
ENSG00000226688 E018 69.8974659 0.0493049477 0.39613972 0.62525919 10 95872114 95873017 904 - 1.918 1.746 -0.581
ENSG00000226688 E019 3.9237295 0.0078170811 0.77957711 0.88446063 10 95873018 95873023 6 - 0.719 0.670 -0.204
ENSG00000226688 E020 5.4059010 0.0537241308 0.99823626 1.00000000 10 95873024 95873045 22 - 0.817 0.794 -0.091
ENSG00000226688 E021 3.7390705 0.0081701593 0.09457015 0.27220654 10 95873046 95873070 25 - 0.550 0.789 1.018
ENSG00000226688 E022 4.4491074 0.0067956153 0.99757310 1.00000000 10 95873071 95873084 14 - 0.742 0.734 -0.034
ENSG00000226688 E023 5.9380037 0.0050536635 0.67391943 0.81884748 10 95873085 95873087 3 - 0.875 0.814 -0.237
ENSG00000226688 E024 37.1379287 0.0073020615 0.12949028 0.33101165 10 95873088 95873166 79 - 1.542 1.634 0.314
ENSG00000226688 E025 52.5633523 0.0008933837 0.02351035 0.10757839 10 95873167 95873258 92 - 1.688 1.790 0.345
ENSG00000226688 E026 184.5778617 0.2679936654 0.25106394 0.48912379 10 95873259 95873760 502 - 2.232 2.305 0.246
ENSG00000226688 E027 52.3011080 0.0010416431 0.70783194 0.84047310 10 95873761 95873777 17 - 1.733 1.743 0.035
ENSG00000226688 E028 96.5103469 0.0624701827 0.45655176 0.67065998 10 95873778 95873944 167 - 1.981 1.997 0.053
ENSG00000226688 E029 72.8584924 0.0515290975 0.66084536 0.81047109 10 95873945 95874027 83 - 1.867 1.869 0.007
ENSG00000226688 E030 303.2895054 0.6872802056 0.39234677 0.62227637 10 95874028 95875133 1106 - 2.463 2.501 0.125
ENSG00000226688 E031 34.0190393 0.0014903223 0.51440860 0.71126458 10 95875134 95875174 41 - 1.576 1.528 -0.166
ENSG00000226688 E032 54.8913512 0.0075191596 0.71975557 0.84804936 10 95875175 95875268 94 - 1.747 1.754 0.024
ENSG00000226688 E033 35.3053152 0.0050242840 0.12539565 0.32445575 10 95875269 95875281 13 - 1.519 1.611 0.314
ENSG00000226688 E034 53.7850883 0.0007933193 0.46274805 0.67498035 10 95875282 95875336 55 - 1.736 1.763 0.092
ENSG00000226688 E035 62.2165262 0.0008558271 0.52826122 0.72081848 10 95875337 95875387 51 - 1.804 1.824 0.068
ENSG00000226688 E036 48.0841244 0.0009874770 0.55310783 0.73847581 10 95875388 95875408 21 - 1.717 1.678 -0.132
ENSG00000226688 E037 128.8308794 0.1825783136 0.53276900 0.72404781 10 95875409 95875666 258 - 2.129 2.087 -0.138
ENSG00000226688 E038 52.1409515 0.0031406610 0.12919808 0.33049356 10 95875667 95876517 851 - 1.703 1.780 0.259
ENSG00000226688 E039 78.1407463 0.0112239443 0.85619560 0.92836660 10 95876518 95876660 143 - 1.917 1.886 -0.106
ENSG00000226688 E040 0.5177432 0.0386910631 0.53283851   10 95876661 95876661 1 - 0.108 0.240 1.384
ENSG00000226688 E041 1.4576584 0.9503579501 0.92091114 0.96270136 10 95878225 95878263 39 - 0.337 0.446 0.609
ENSG00000226688 E042 2.1196290 0.6833019980 0.87365047 0.93799631 10 95878264 95878826 563 - 0.388 0.595 1.025
ENSG00000226688 E043 1.7554343 0.0833659455 0.84858066 0.92412362 10 95894448 95894487 40 - 0.430 0.499 0.349
ENSG00000226688 E044 8.8288641 0.0472914822 0.93200082 0.96812086 10 95897528 95897557 30 - 0.989 1.005 0.060
ENSG00000226688 E045 20.8480517 0.2802107922 0.43085914 0.65177703 10 95897558 95897679 122 - 1.341 1.332 -0.033
ENSG00000226688 E046 18.5331864 0.3535340092 0.48112614 0.68784440 10 95898887 95899018 132 - 1.291 1.286 -0.020
ENSG00000226688 E047 2.0491909 0.1036678472 0.69665858 0.83342638 10 95904656 95904829 174 - 0.514 0.451 -0.309
ENSG00000226688 E048 57.4492485 0.0747996387 0.17495034 0.39710280 10 95904830 95904935 106 - 1.797 1.725 -0.244
ENSG00000226688 E049 21.4944681 0.0583371936 0.79030835 0.89073598 10 95904936 95904938 3 - 1.338 1.382 0.155
ENSG00000226688 E050 46.0089062 0.0122016803 0.83577712 0.91703389 10 95907663 95907777 115 - 1.684 1.678 -0.021
ENSG00000226688 E051 43.8693715 0.0850634124 0.38378580 0.61539679 10 95907778 95908178 401 - 1.658 1.645 -0.042
ENSG00000226688 E052 1.3108423 0.0215829465 0.74138785   10 95908601 95909131 531 - 0.383 0.323 -0.361
ENSG00000226688 E053 0.0000000       10 95918938 95921485 2548 -      
ENSG00000226688 E054 2.3398820 0.0179772836 0.42467430 0.64704927 10 95921486 95921597 112 - 0.583 0.452 -0.626
ENSG00000226688 E055 0.1779838 1.7197651618 0.64072839   10 95938106 95939962 1857 - 0.112 0.000 -12.109
ENSG00000226688 E056 0.0000000       10 95939963 95940131 169 -      
ENSG00000226688 E057 0.0000000       10 95941222 95941292 71 -      
ENSG00000226688 E058 0.6081007 0.0200680271 0.06811421   10 95950458 95950528 71 - 0.329 0.000 -14.047
ENSG00000226688 E059 0.3228314 0.2854042165 0.31761504   10 95981466 95981593 128 - 0.195 0.000 -13.053
ENSG00000226688 E060 0.2027342 0.6860181029 0.67243217   10 95996105 95996281 177 - 0.000 0.141 12.828
ENSG00000226688 E061 3.1363280 0.4201688839 0.01975417 0.09506126 10 96018720 96021275 2556 - 0.779 0.240 -2.767
ENSG00000226688 E062 0.0000000       10 96021276 96021277 2 -      
ENSG00000226688 E063 1.1190667 0.0710619860 1.00000000   10 96021278 96021568 291 - 0.329 0.323 -0.042
ENSG00000226688 E064 0.0000000       10 96022544 96022714 171 -      
ENSG00000226688 E065 0.1614157 0.1488243024 0.55083050   10 96027207 96027345 139 - 0.108 0.000 -12.050
ENSG00000226688 E066 2.8451212 0.0086425813 0.42131182 0.64460375 10 96042478 96042784 307 - 0.550 0.669 0.527
ENSG00000226688 E067 2.7969055 0.2623968173 0.48561906 0.69099268 10 96042785 96042927 143 - 0.611 0.548 -0.286
ENSG00000226688 E068 0.5530924 0.6297940280 0.76334391   10 96044875 96044913 39 - 0.110 0.248 1.414
ENSG00000226688 E069 0.5171231 1.3806352971 0.54130104   10 96058944 96059907 964 - 0.000 0.332 14.407
ENSG00000226688 E070 0.4279040 0.2741739382 0.21332877   10 96087551 96087757 207 - 0.263 0.000 -13.600
ENSG00000226688 E071 2.7480543 0.3787152661 0.91718192 0.96078750 10 96088009 96088908 900 - 0.511 0.639 0.582
ENSG00000226688 E072 1.5273116 1.0538922960 0.86966207 0.93566185 10 96088909 96089230 322 - 0.337 0.461 0.690
ENSG00000226688 E073 0.5117739 0.5322588925 0.58456020   10 96089231 96089265 35 - 0.198 0.137 -0.631
ENSG00000226688 E074 5.9930523 0.5058756685 0.58258011 0.75876021 10 96089266 96089307 42 - 0.846 0.837 -0.035
ENSG00000226688 E075 0.3503582 1.1192911227 0.89632411   10 96089308 96089442 135 - 0.111 0.138 0.362
ENSG00000226688 E076 0.1614157 0.1488243024 0.55083050   10 96089443 96089538 96 - 0.108 0.000 -12.050
ENSG00000226688 E077 1.8578479 0.0110064695 0.91520274 0.95975872 10 96089539 96089981 443 - 0.474 0.453 -0.111
ENSG00000226688 E078 12.8118288 0.4739660809 0.55561505 0.74021711 10 96089982 96090250 269 - 1.141 1.130 -0.040