ENSG00000225361

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000455039 ENSG00000225361 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1R26-AS1 lncRNA lncRNA 3.326094 3.979597 3.221813 0.820965 0.3874487 -0.3038994 0.5441574 0.5511066 0.8229828 0.14781377 0.05201298 0.5700117 0.1683833 0.1340333 0.26633333 0.132300000 3.053001e-01 3.540382e-07   FALSE
ENST00000603624 ENSG00000225361 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1R26-AS1 lncRNA lncRNA 3.326094 3.979597 3.221813 0.820965 0.3874487 -0.3038994 0.4174497 0.6099994 0.0000000 0.05185531 0.00000000 -5.9541950 0.1350208 0.1631000 0.00000000 -0.163100000 3.540382e-07 3.540382e-07   FALSE
ENST00000603893 ENSG00000225361 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1R26-AS1 lncRNA lncRNA 3.326094 3.979597 3.221813 0.820965 0.3874487 -0.3038994 0.2804739 0.5851028 0.3778116 0.12845087 0.20046120 -0.6177829 0.0841875 0.1472667 0.10496667 -0.042300000 8.370144e-01 3.540382e-07   FALSE
ENST00000605260 ENSG00000225361 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1R26-AS1 lncRNA lncRNA 3.326094 3.979597 3.221813 0.820965 0.3874487 -0.3038994 0.5323252 0.6118012 0.2315054 0.38410065 0.08229145 -1.3643980 0.1552083 0.1244000 0.06903333 -0.055366667 9.586351e-01 3.540382e-07   FALSE
ENST00000655118 ENSG00000225361 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1R26-AS1 lncRNA lncRNA 3.326094 3.979597 3.221813 0.820965 0.3874487 -0.3038994 0.6140976 0.7435937 0.6446708 0.09455842 0.18424564 -0.2030172 0.1832583 0.1954000 0.19383333 -0.001566667 1.000000e+00 3.540382e-07   FALSE
ENST00000660718 ENSG00000225361 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1R26-AS1 lncRNA lncRNA 3.326094 3.979597 3.221813 0.820965 0.3874487 -0.3038994 0.4761552 0.4585807 0.2105685 0.12834441 0.15248916 -1.0870711 0.1389708 0.1139667 0.06850000 -0.045466667 7.440835e-01 3.540382e-07   FALSE
MSTRG.33605.4 ENSG00000225361 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1R26-AS1 lncRNA   3.326094 3.979597 3.221813 0.820965 0.3874487 -0.3038994 0.4614349 0.4194124 0.9342735 0.04694739 0.02772960 1.1368411 0.1349792 0.1218000 0.29730000 0.175500000 1.360097e-01 3.540382e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000225361 E001 0.7788594 0.019387492 0.1373734954   9 135462727 135462745 19 - 0.001 0.308 9.625
ENSG00000225361 E002 15.3263482 0.003739564 0.0082047369 0.050279414 9 135462746 135463168 423 - 1.002 1.238 0.848
ENSG00000225361 E003 24.7758835 0.041820117 0.4803420265 0.687313572 9 135463169 135463527 359 - 1.358 1.377 0.066
ENSG00000225361 E004 48.9839345 0.002302313 0.0038026289 0.028035680 9 135463528 135464749 1222 - 1.576 1.693 0.400
ENSG00000225361 E005 12.3351578 0.003368714 0.3863297226 0.617566229 9 135464750 135464850 101 - 1.164 1.055 -0.392
ENSG00000225361 E006 7.3390383 0.004091317 0.0605864019 0.204158274 9 135468088 135468171 84 - 1.044 0.804 -0.905
ENSG00000225361 E007 23.9666438 0.129923296 0.0996455308 0.281130746 9 135468172 135468709 538 - 1.498 1.283 -0.746
ENSG00000225361 E008 5.7641537 0.030756615 0.6967839261 0.833497244 9 135468710 135469025 316 - 0.743 0.806 0.249
ENSG00000225361 E009 4.2403537 0.067264953 0.3663489694 0.600987903 9 135471626 135471993 368 - 0.545 0.730 0.802
ENSG00000225361 E010 2.9676936 0.051611503 0.0195057081 0.094212823 9 135472077 135472249 173 - 0.177 0.657 2.815
ENSG00000225361 E011 3.7095835 0.088952621 0.0602050516 0.203296796 9 135472460 135472577 118 - 0.850 0.514 -1.423
ENSG00000225361 E012 4.0815540 0.006614175 0.3739217514 0.607294682 9 135480315 135480672 358 - 0.781 0.634 -0.607
ENSG00000225361 E013 7.0487454 0.004578337 0.0003007932 0.003738135 9 135480673 135480777 105 - 1.133 0.693 -1.678