ENSG00000225190

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000430334 ENSG00000225190 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM1 protein_coding protein_coding 9.815118 15.9473 5.843361 1.424051 0.4803374 -1.446879 5.23937118 8.4358115 3.25615737 1.22739514 0.14678692 -1.3706417 0.55070417 0.52386667 0.567933333 0.044066667 0.91986246 0.04036429 FALSE TRUE
ENST00000580404 ENSG00000225190 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM1 protein_coding processed_transcript 9.815118 15.9473 5.843361 1.424051 0.4803374 -1.446879 1.17343613 1.3168848 0.03100526 0.31054015 0.03100526 -5.0160904 0.09027500 0.08633333 0.005633333 -0.080700000 0.04274418 0.04036429 FALSE TRUE
ENST00000581448 ENSG00000225190 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM1 protein_coding nonsense_mediated_decay 9.815118 15.9473 5.843361 1.424051 0.4803374 -1.446879 0.85965486 1.3371745 0.53282077 0.19120706 0.23494188 -1.3113889 0.09945000 0.08426667 0.086900000 0.002633333 1.00000000 0.04036429 FALSE TRUE
ENST00000586562 ENSG00000225190 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM1 protein_coding processed_transcript 9.815118 15.9473 5.843361 1.424051 0.4803374 -1.446879 0.26016379 0.2384013 0.39894572 0.09999122 0.10417212 0.7192368 0.03135000 0.01406667 0.066600000 0.052533333 0.04036429 0.04036429 TRUE FALSE
MSTRG.14495.6 ENSG00000225190 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEKHM1 protein_coding   9.815118 15.9473 5.843361 1.424051 0.4803374 -1.446879 0.09625752 0.0000000 0.34229713 0.00000000 0.17595077 5.1387208 0.01420833 0.00000000 0.055533333 0.055533333 0.10612355 0.04036429 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000225190 E001 0.5540201 0.2546813229 7.770869e-01   17 45435900 45435902 3 - 0.196 0.184 -0.110
ENSG00000225190 E002 0.5540201 0.2546813229 7.770869e-01   17 45435903 45435903 1 - 0.196 0.184 -0.110
ENSG00000225190 E003 266.7575390 1.1004940289 3.585943e-01 0.5946272898 17 45435904 45437470 1567 - 2.119 2.414 0.984
ENSG00000225190 E004 35.2191130 0.1107407455 1.050113e-01 0.2906487306 17 45437471 45437548 78 - 1.256 1.549 1.017
ENSG00000225190 E005 34.1038619 0.0893828269 6.707350e-02 0.2185670789 17 45437549 45437629 81 - 1.216 1.540 1.124
ENSG00000225190 E006 91.6175314 0.4228544273 1.738908e-01 0.3957260749 17 45437630 45437915 286 - 1.636 1.957 1.086
ENSG00000225190 E007 50.9523067 0.2321234820 1.252398e-01 0.3241522111 17 45437916 45437969 54 - 1.393 1.706 1.073
ENSG00000225190 E008 46.4332359 0.1128094477 8.691764e-02 0.2580933081 17 45439477 45439513 37 - 1.377 1.664 0.982
ENSG00000225190 E009 47.1606849 0.0321529586 1.023690e-01 0.2860203562 17 45439514 45439545 32 - 1.444 1.661 0.743
ENSG00000225190 E010 43.0979793 0.0016675163 3.247753e-01 0.5640135042 17 45439546 45439577 32 - 1.476 1.610 0.458
ENSG00000225190 E011 38.8735576 0.0012548771 4.931165e-01 0.6960534281 17 45439578 45439614 37 - 1.442 1.559 0.400
ENSG00000225190 E012 39.6001817 0.0071024686 3.777965e-01 0.6103884130 17 45439615 45439634 20 - 1.538 1.541 0.010
ENSG00000225190 E013 0.8987688 0.0183827513 7.903607e-01   17 45440027 45440162 136 - 0.195 0.282 0.686
ENSG00000225190 E014 54.6475770 0.0028999888 6.555274e-01 0.8070613697 17 45440163 45440226 64 - 1.604 1.700 0.326
ENSG00000225190 E015 6.0656495 0.0057916820 2.205045e-01 0.4541034944 17 45440227 45440373 147 - 0.584 0.837 1.047
ENSG00000225190 E016 4.4538792 0.1689850650 8.990007e-01 0.9513574517 17 45440837 45441059 223 - 0.649 0.694 0.189
ENSG00000225190 E017 87.5079193 0.0069247121 6.722086e-01 0.8177062092 17 45445470 45445663 194 - 1.844 1.892 0.162
ENSG00000225190 E018 4.5746961 0.0811293024 3.767495e-01 0.6096623328 17 45446129 45446273 145 - 0.513 0.744 1.012
ENSG00000225190 E019 2.0451021 0.3904947078 4.179470e-01 0.6420945813 17 45447912 45448112 201 - 0.193 0.501 1.951
ENSG00000225190 E020 52.9650045 0.0057935778 7.460792e-01 0.8644134464 17 45450618 45450763 146 - 1.628 1.677 0.166
ENSG00000225190 E021 9.4528188 0.0033683919 6.387278e-01 0.7961665389 17 45452938 45453354 417 - 0.860 0.983 0.465
ENSG00000225190 E022 108.5992519 0.0225076208 7.640355e-01 0.8750685970 17 45453355 45453973 619 - 1.931 1.985 0.179
ENSG00000225190 E023 90.3464267 0.0110269212 1.519906e-01 0.3652552571 17 45453974 45454272 299 - 1.905 1.893 -0.042
ENSG00000225190 E024 1.1428216 0.0139888844 1.378827e-01   17 45454273 45454771 499 - 0.000 0.358 11.480
ENSG00000225190 E025 84.5776693 0.0006431933 7.123843e-02 0.2272429093 17 45458169 45458439 271 - 1.877 1.869 -0.027
ENSG00000225190 E026 0.3337900 0.0296879024 3.453385e-01   17 45459383 45460432 1050 - 0.195 0.073 -1.631
ENSG00000225190 E027 18.9609991 0.0110547748 1.247410e-01 0.3233342178 17 45468209 45468245 37 - 1.296 1.218 -0.275
ENSG00000225190 E028 82.8805723 0.0040600332 1.084856e-03 0.0105638498 17 45468246 45468593 348 - 1.927 1.832 -0.319
ENSG00000225190 E029 53.4753411 0.0097341324 2.029050e-03 0.0172513906 17 45475100 45475210 111 - 1.771 1.630 -0.478
ENSG00000225190 E030 58.6527830 0.0022221072 1.254772e-03 0.0118258015 17 45475211 45475362 152 - 1.787 1.684 -0.348
ENSG00000225190 E031 21.7883571 0.0017838347 2.369889e-01 0.4730736571 17 45475363 45475365 3 - 1.320 1.290 -0.105
ENSG00000225190 E032 45.2266623 0.0032230297 6.000515e-01 0.7702481428 17 45475366 45475435 70 - 1.572 1.612 0.135
ENSG00000225190 E033 62.1745699 0.0281538468 5.373822e-01 0.7272344588 17 45475436 45475596 161 - 1.716 1.741 0.085
ENSG00000225190 E034 47.7876500 0.0018114349 4.521132e-02 0.1681421312 17 45475597 45475695 99 - 1.662 1.615 -0.159
ENSG00000225190 E035 43.8461886 0.0010036084 4.029771e-05 0.0006923094 17 45475696 45475726 31 - 1.707 1.538 -0.575
ENSG00000225190 E036 6.2198042 0.0080905354 1.308643e-03 0.0122268078 17 45475888 45476073 186 - 1.050 0.700 -1.348
ENSG00000225190 E037 11.3950862 0.0145147556 3.907730e-03 0.0286402141 17 45477074 45477804 731 - 1.214 0.955 -0.938
ENSG00000225190 E038 5.9896746 0.0047935149 6.801716e-01 0.8228245704 17 45477805 45477899 95 - 0.786 0.787 0.005
ENSG00000225190 E039 69.4291138 0.0005463681 1.234545e-02 0.0678162873 17 45477900 45478100 201 - 1.821 1.773 -0.165
ENSG00000225190 E040 32.7540512 0.0012665750 4.727257e-01 0.6819836328 17 45478101 45478147 47 - 1.451 1.468 0.060
ENSG00000225190 E041 31.8443517 0.0080164790 2.662625e-01 0.5057603582 17 45482437 45482525 89 - 1.476 1.452 -0.083
ENSG00000225190 E042 0.0000000       17 45487728 45487862 135 -      
ENSG00000225190 E043 20.9663906 0.0185015410 3.008669e-01 0.5413487139 17 45490652 45490839 188 - 1.318 1.276 -0.150