ENSG00000223891

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435163 ENSG00000223891 HEK293_OSMI2_6hA HEK293_TMG_6hB OSER1-DT lncRNA lncRNA 3.118306 4.25244 2.329613 0.1701472 0.2124866 -0.8654095 0.29833214 0.52499061 0.03409174 0.08477388 0.03409174 -3.600933 0.08808333 0.125433333 0.015133333 -0.11030000 1.009119e-01 1.971968e-06   FALSE
ENST00000439943 ENSG00000223891 HEK293_OSMI2_6hA HEK293_TMG_6hB OSER1-DT lncRNA lncRNA 3.118306 4.25244 2.329613 0.1701472 0.2124866 -0.8654095 0.24225939 0.84887589 0.09638144 0.14301928 0.09638144 -3.013203 0.07061667 0.199066667 0.042833333 -0.15623333 2.629458e-01 1.971968e-06   FALSE
ENST00000442383 ENSG00000223891 HEK293_OSMI2_6hA HEK293_TMG_6hB OSER1-DT lncRNA lncRNA 3.118306 4.25244 2.329613 0.1701472 0.2124866 -0.8654095 1.00476884 1.41237494 0.19642385 0.08091133 0.15079962 -2.784620 0.30215833 0.333166667 0.074433333 -0.25873333 2.380182e-01 1.971968e-06   FALSE
ENST00000655968 ENSG00000223891 HEK293_OSMI2_6hA HEK293_TMG_6hB OSER1-DT lncRNA lncRNA 3.118306 4.25244 2.329613 0.1701472 0.2124866 -0.8654095 0.23144873 0.35915611 0.02063657 0.24756487 0.02063657 -3.590904 0.06400833 0.080200000 0.009166667 -0.07103333 7.194909e-01 1.971968e-06   FALSE
ENST00000660003 ENSG00000223891 HEK293_OSMI2_6hA HEK293_TMG_6hB OSER1-DT lncRNA lncRNA 3.118306 4.25244 2.329613 0.1701472 0.2124866 -0.8654095 0.10571213 0.03117161 0.24391265 0.03117161 0.12196108 2.624611 0.03960833 0.006833333 0.105333333 0.09850000 4.646387e-01 1.971968e-06   FALSE
ENST00000664132 ENSG00000223891 HEK293_OSMI2_6hA HEK293_TMG_6hB OSER1-DT lncRNA lncRNA 3.118306 4.25244 2.329613 0.1701472 0.2124866 -0.8654095 0.07444256 0.00000000 0.11530746 0.00000000 0.11530746 3.647400 0.04185000 0.000000000 0.057433333 0.05743333 7.830350e-01 1.971968e-06   FALSE
ENST00000671199 ENSG00000223891 HEK293_OSMI2_6hA HEK293_TMG_6hB OSER1-DT lncRNA lncRNA 3.118306 4.25244 2.329613 0.1701472 0.2124866 -0.8654095 0.89983242 0.62696771 1.44332566 0.11947025 0.15913490 1.190066 0.31137500 0.149266667 0.618666667 0.46940000 1.971968e-06 1.971968e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000223891 E001 0.4644705 0.025035270 0.2398975380   20 44210907 44210942 36 + 0.001 0.233 9.201
ENSG00000223891 E002 0.6071052 0.021814079 0.6978668369   20 44210943 44210959 17 + 0.158 0.233 0.701
ENSG00000223891 E003 0.7968555 0.017708901 0.2473975497   20 44210960 44210991 32 + 0.364 0.169 -1.467
ENSG00000223891 E004 0.7968555 0.017708901 0.2473975497   20 44210992 44210994 3 + 0.364 0.169 -1.467
ENSG00000223891 E005 4.5526525 0.013710141 0.0010861134 0.010573061 20 44210995 44211011 17 + 0.969 0.528 -1.807
ENSG00000223891 E006 6.0838946 0.006393039 0.0007102572 0.007529214 20 44211012 44211019 8 + 1.044 0.637 -1.596
ENSG00000223891 E007 7.7726219 0.004271892 0.0004631637 0.005339116 20 44211020 44211026 7 + 1.123 0.742 -1.440
ENSG00000223891 E008 8.3206727 0.003538860 0.0003664932 0.004402871 20 44211027 44211036 10 + 1.151 0.777 -1.398
ENSG00000223891 E009 11.5458739 0.002972180 0.0014387596 0.013177353 20 44211037 44211077 41 + 1.236 0.947 -1.046
ENSG00000223891 E010 1.3168116 0.014160064 0.3681417225   20 44211078 44211081 4 + 0.440 0.290 -0.880
ENSG00000223891 E011 13.5338369 0.002752434 0.0006061618 0.006632318 20 44211082 44211356 275 + 0.853 1.229 1.378
ENSG00000223891 E012 1.9284736 0.158599486 0.6108483829 0.777509574 20 44212834 44214887 2054 + 0.505 0.425 -0.403
ENSG00000223891 E013 5.3417805 0.018311717 0.0820055237 0.248761661 20 44214888 44214897 10 + 0.560 0.845 1.191
ENSG00000223891 E014 9.3749655 0.003520062 0.0064111539 0.041732584 20 44214898 44215003 106 + 0.731 1.077 1.320
ENSG00000223891 E015 8.5047658 0.038556061 0.8189186416 0.907396521 20 44217367 44217682 316 + 0.927 0.979 0.192
ENSG00000223891 E016 1.7418596 0.325296414 0.2023215484 0.432556807 20 44217683 44218751 1069 + 0.156 0.526 2.445
ENSG00000223891 E017 16.6636544 0.002443548 0.0130800523 0.070773393 20 44219789 44223718 3930 + 1.045 1.286 0.862
ENSG00000223891 E018 0.7143205 0.029798833 0.6967486870   20 44223719 44223872 154 + 0.158 0.234 0.703
ENSG00000223891 E019 94.3680958 0.009963334 0.1435347652 0.352685483 20 44224821 44226027 1207 + 1.908 1.980 0.242