ENSG00000221978

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000400809 ENSG00000221978 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNL2 protein_coding protein_coding 75.00439 90.41765 72.3492 25.46782 2.021569 -0.3215875 6.684141 10.082337 4.720498 0.7336792 0.08323091 -1.09319644 0.09137083 0.12406667 0.06543333 -0.05863333 2.602152e-01 1.712814e-06 FALSE  
ENST00000408918 ENSG00000221978 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNL2 protein_coding protein_coding 75.00439 90.41765 72.3492 25.46782 2.021569 -0.3215875 17.280766 18.801942 18.107552 6.2882250 0.97669241 -0.05426081 0.23290417 0.20370000 0.24990000 0.04620000 5.177504e-01 1.712814e-06 FALSE  
ENST00000418865 ENSG00000221978 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNL2 protein_coding retained_intron 75.00439 90.41765 72.3492 25.46782 2.021569 -0.3215875 19.999220 22.424628 20.200242 9.0161352 0.75614497 -0.15064063 0.26028333 0.23320000 0.27906667 0.04586667 7.066880e-01 1.712814e-06 FALSE  
ENST00000473872 ENSG00000221978 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNL2 protein_coding retained_intron 75.00439 90.41765 72.3492 25.46782 2.021569 -0.3215875 8.028571 7.354612 11.897123 2.5300035 0.30772960 0.69314347 0.10772500 0.07883333 0.16450000 0.08566667 1.712814e-06 1.712814e-06 FALSE  
ENST00000481223 ENSG00000221978 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNL2 protein_coding nonsense_mediated_decay 75.00439 90.41765 72.3492 25.46782 2.021569 -0.3215875 4.573969 9.081987 1.643132 2.4601353 0.84207727 -2.45939382 0.06078333 0.10310000 0.02280000 -0.08030000 5.371501e-01 1.712814e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000221978 E001 90.433463 0.0070261001 8.574133e-03 5.192885e-02 1 1385711 1386278 568 - 1.850 1.969 0.401
ENSG00000221978 E002 60.059720 0.0100568838 2.791439e-02 1.210287e-01 1 1386279 1386481 203 - 1.677 1.796 0.403
ENSG00000221978 E003 24.224597 0.0183448650 1.141161e-01 3.059460e-01 1 1386482 1386494 13 - 1.294 1.415 0.422
ENSG00000221978 E004 20.991453 0.0125171914 9.833109e-02 2.788460e-01 1 1386495 1386496 2 - 1.229 1.359 0.455
ENSG00000221978 E005 18.272439 0.0167390493 3.391360e-01 5.772008e-01 1 1386497 1386498 2 - 1.217 1.287 0.247
ENSG00000221978 E006 18.540145 0.0232775655 2.411724e-01 4.779069e-01 1 1386499 1386501 3 - 1.204 1.301 0.341
ENSG00000221978 E007 116.617787 0.0017325948 1.425688e-02 7.537817e-02 1 1386502 1386707 206 - 1.991 2.070 0.265
ENSG00000221978 E008 61.262144 0.0006155594 1.837709e-01 4.088150e-01 1 1386708 1386712 5 - 1.735 1.783 0.164
ENSG00000221978 E009 612.629771 0.0021681986 5.448867e-05 8.966501e-04 1 1386713 1387121 409 - 2.703 2.788 0.281
ENSG00000221978 E010 404.622570 0.0020205100 4.531964e-04 5.250591e-03 1 1387122 1387231 110 - 2.529 2.606 0.254
ENSG00000221978 E011 209.477631 0.0011731430 8.327660e-02 2.513335e-01 1 1387232 1387234 3 - 2.275 2.310 0.117
ENSG00000221978 E012 695.480818 0.0014577863 5.285790e-04 5.935652e-03 1 1387235 1387542 308 - 2.777 2.835 0.192
ENSG00000221978 E013 259.092768 0.0002308826 2.292414e-03 1.900345e-02 1 1387543 1387582 40 - 2.348 2.405 0.190
ENSG00000221978 E014 363.123285 0.0005668631 5.672953e-02 1.953599e-01 1 1387777 1387869 93 - 2.518 2.543 0.082
ENSG00000221978 E015 347.574216 0.0002172231 6.911570e-03 4.423046e-02 1 1387954 1388022 69 - 2.487 2.526 0.133
ENSG00000221978 E016 284.178293 0.0002078254 2.489867e-03 2.026827e-02 1 1388023 1388065 43 - 2.390 2.444 0.180
ENSG00000221978 E017 25.636954 0.0020418871 8.377908e-01 9.181998e-01 1 1388066 1388491 426 - 1.416 1.383 -0.114
ENSG00000221978 E018 7.579612 0.0095654886 6.854170e-01 8.261089e-01 1 1388492 1388510 19 - 0.868 0.910 0.158
ENSG00000221978 E019 8.150821 0.0040184181 8.082940e-01 9.011924e-01 1 1388511 1388625 115 - 0.919 0.932 0.052
ENSG00000221978 E020 14.647761 0.0023125834 8.540104e-02 2.553485e-01 1 1388626 1388743 118 - 1.060 1.213 0.549
ENSG00000221978 E021 11.320350 0.0043016880 8.556369e-02 2.556239e-01 1 1388950 1389047 98 - 1.192 1.005 -0.675
ENSG00000221978 E022 16.939426 0.0520785278 9.987031e-01 1.000000e+00 1 1389346 1389473 128 - 1.226 1.224 -0.008
ENSG00000221978 E023 437.836436 0.0001672878 1.070039e-01 2.939790e-01 1 1390230 1390371 142 - 2.606 2.619 0.043
ENSG00000221978 E024 407.102519 0.0001813690 5.772704e-01 7.552920e-01 1 1390459 1390563 105 - 2.586 2.581 -0.015
ENSG00000221978 E025 359.037547 0.0001560077 3.744069e-01 6.076919e-01 1 1390766 1390865 100 - 2.527 2.528 0.006
ENSG00000221978 E026 406.601672 0.0110202457 4.185372e-01 6.425320e-01 1 1390866 1391152 287 - 2.600 2.574 -0.085
ENSG00000221978 E027 291.170634 0.0067674747 5.414727e-01 7.301083e-01 1 1391153 1391296 144 - 2.451 2.433 -0.060
ENSG00000221978 E028 130.339998 0.0035312468 9.762620e-01 9.899020e-01 1 1391297 1391306 10 - 2.095 2.090 -0.016
ENSG00000221978 E029 344.146404 0.0041027577 2.524694e-01 4.905619e-01 1 1391307 1391553 247 - 2.537 2.497 -0.132
ENSG00000221978 E030 129.973375 0.0068290088 2.314650e-02 1.064086e-01 1 1391554 1391575 22 - 2.162 2.048 -0.382
ENSG00000221978 E031 487.801902 0.0102745544 7.009918e-04 7.451382e-03 1 1391576 1392287 712 - 2.760 2.604 -0.518
ENSG00000221978 E032 394.568847 0.0103452043 1.162274e-03 1.114139e-02 1 1392288 1392678 391 - 2.674 2.508 -0.553
ENSG00000221978 E033 248.412743 0.0031360185 1.708847e-02 8.578788e-02 1 1392679 1392789 111 - 2.429 2.335 -0.313
ENSG00000221978 E034 142.239483 0.0004231742 1.379898e-01 3.444531e-01 1 1392790 1392803 14 - 2.168 2.106 -0.208
ENSG00000221978 E035 97.085116 0.0078731602 9.369688e-11 6.689753e-09 1 1393080 1393395 316 - 2.172 1.806 -1.228
ENSG00000221978 E036 273.666360 0.0035253746 2.847096e-01 5.252548e-01 1 1393396 1393443 48 - 2.456 2.390 -0.221
ENSG00000221978 E037 201.012636 0.0017130320 1.634119e-01 3.818101e-01 1 1393444 1393460 17 - 2.323 2.255 -0.227
ENSG00000221978 E038 24.694526 0.0147737304 3.259966e-05 5.792792e-04 1 1395185 1395393 209 - 1.595 1.206 -1.349
ENSG00000221978 E039 222.270488 0.0074518443 8.822165e-01 9.424574e-01 1 1395394 1395436 43 - 2.342 2.312 -0.099
ENSG00000221978 E040 300.081687 0.0039052797 7.092290e-02 2.265608e-01 1 1395437 1395514 78 - 2.515 2.418 -0.323
ENSG00000221978 E041 2.383574 0.0195927429 3.341928e-01 5.727713e-01 1 1395515 1395537 23 - 0.374 0.547 0.886
ENSG00000221978 E042 321.241002 0.0036300017 2.455767e-01 4.830859e-01 1 1398233 1398342 110 - 2.528 2.457 -0.235
ENSG00000221978 E043 5.564411 0.0054324557 9.248953e-02 2.683739e-01 1 1398343 1398366 24 - 0.942 0.708 -0.914
ENSG00000221978 E044 245.081781 0.0025897904 3.977438e-01 6.265809e-01 1 1398597 1398671 75 - 2.395 2.350 -0.150
ENSG00000221978 E045 4.369269 0.2394951213 4.897490e-01 6.938259e-01 1 1398672 1398956 285 - 0.777 0.672 -0.434
ENSG00000221978 E046 3.598712 0.0073522163 1.974382e-01 4.264293e-01 1 1398988 1399018 31 - 0.515 0.708 0.853
ENSG00000221978 E047 265.341302 0.0010192680 6.229320e-02 2.079335e-01 1 1399019 1399335 317 - 2.378 2.410 0.108