ENSG00000221923

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344085 ENSG00000221923 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF880 protein_coding protein_coding 2.946538 2.847364 3.437706 0.314758 0.1858046 0.2709522 0.8409571 0.86617779 0.7742592 0.30938672 0.16324283 -0.1598931 0.27745833 0.28903333 0.2225667 -0.06646667 0.881480500 0.001211803 FALSE TRUE
ENST00000422689 ENSG00000221923 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF880 protein_coding protein_coding 2.946538 2.847364 3.437706 0.314758 0.1858046 0.2709522 0.1867334 0.03937807 0.4487465 0.03937807 0.06586977 3.2157546 0.06388750 0.01136667 0.1293000 0.11793333 0.001211803 0.001211803 FALSE TRUE
ENST00000597976 ENSG00000221923 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF880 protein_coding protein_coding 2.946538 2.847364 3.437706 0.314758 0.1858046 0.2709522 0.1412967 0.10404035 0.0000000 0.05749690 0.00000000 -3.5114725 0.05375833 0.04150000 0.0000000 -0.04150000 0.273265083 0.001211803 FALSE TRUE
ENST00000600321 ENSG00000221923 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF880 protein_coding protein_coding 2.946538 2.847364 3.437706 0.314758 0.1858046 0.2709522 1.7530989 1.81142725 2.1864841 0.08700596 0.08274582 0.2701267 0.59522917 0.64793333 0.6394333 -0.00850000 1.000000000 0.001211803 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000221923 E001 0.2027342 0.034585132 4.167210e-01   19 52369917 52369922 6 + 0.000 0.130 9.815
ENSG00000221923 E002 0.5067846 0.021768165 6.688184e-01   19 52369923 52369935 13 + 0.203 0.130 -0.766
ENSG00000221923 E003 4.8617215 0.006884833 6.518159e-01 8.046620e-01 19 52369936 52369938 3 + 0.737 0.796 0.234
ENSG00000221923 E004 6.2375352 0.005841887 4.994992e-01 7.004355e-01 19 52369939 52369945 7 + 0.823 0.903 0.307
ENSG00000221923 E005 13.5718191 0.003336094 1.847159e-01 4.101256e-01 19 52369946 52369977 32 + 1.101 1.215 0.408
ENSG00000221923 E006 0.2735028 0.027442404 9.041668e-01   19 52370093 52370602 510 + 0.113 0.130 0.229
ENSG00000221923 E007 22.6554682 0.002604188 4.537449e-01 6.685087e-01 19 52373111 52373237 127 + 1.345 1.394 0.169
ENSG00000221923 E008 21.5112128 0.002781971 4.560687e-01 6.703113e-01 19 52374299 52374394 96 + 1.374 1.321 -0.185
ENSG00000221923 E009 11.5175228 0.003327327 1.452634e-01 3.552945e-01 19 52374395 52374427 33 + 1.158 1.019 -0.506
ENSG00000221923 E010 0.1723744 0.032146289 4.174044e-01   19 52374428 52374483 56 + 0.000 0.130 9.813
ENSG00000221923 E011 4.1378344 0.014551169 1.721738e-01 3.934034e-01 19 52374484 52374717 234 + 0.600 0.796 0.819
ENSG00000221923 E012 10.7043217 0.004008841 4.275418e-01 6.491425e-01 19 52379421 52379540 120 + 1.035 1.110 0.272
ENSG00000221923 E013 20.7387303 0.002124529 6.781042e-02 2.201784e-01 19 52379541 52380075 535 + 1.269 1.394 0.437
ENSG00000221923 E014 10.8725931 0.004569899 6.987272e-08 2.691312e-06 19 52383849 52385795 1947 + 1.255 0.653 -2.280