ENSG00000215712

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367144 ENSG00000215712 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM242 protein_coding protein_coding 20.55701 16.66437 27.53626 2.197181 1.619091 0.7242243 1.129656 0.8157889 1.524937 0.05617141 0.1828233 0.8943342 0.05779167 0.04993333 0.05493333 0.0050000000 0.92609777 0.04074981 FALSE  
ENST00000400788 ENSG00000215712 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM242 protein_coding protein_coding 20.55701 16.66437 27.53626 2.197181 1.619091 0.7242243 1.081858 0.8770520 1.526874 0.08896134 0.1174202 0.7929080 0.05234583 0.05640000 0.05546667 -0.0009333333 1.00000000 0.04074981 FALSE  
MSTRG.29221.1 ENSG00000215712 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM242 protein_coding   20.55701 16.66437 27.53626 2.197181 1.619091 0.7242243 14.105604 12.4450442 17.939335 1.63848813 1.2030474 0.5272003 0.69283333 0.74680000 0.65083333 -0.0959666667 0.04074981 0.04074981 FALSE  
MSTRG.29221.4 ENSG00000215712 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM242 protein_coding   20.55701 16.66437 27.53626 2.197181 1.619091 0.7242243 3.402136 2.0148916 5.405677 0.43392644 0.1386482 1.4192970 0.15741250 0.11780000 0.19786667 0.0800666667 0.12458715 0.04074981 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000215712 E001 9.453690 0.2275169212 2.618298e-01 5.009424e-01 6 157285571 157285644 74 - 0.923 1.120 0.723
ENSG00000215712 E002 8.707172 0.2730312213 4.441651e-01 6.615225e-01 6 157285645 157285699 55 - 0.935 1.048 0.417
ENSG00000215712 E003 10.225451 0.3879399205 6.725005e-01 8.178899e-01 6 157285700 157285779 80 - 1.046 1.048 0.008
ENSG00000215712 E004 34.708929 0.0407567131 8.751014e-01 9.387485e-01 6 157289025 157290209 1185 - 1.538 1.555 0.059
ENSG00000215712 E005 7.195638 0.0403993952 8.203636e-01 9.083101e-01 6 157290210 157290231 22 - 0.934 0.893 -0.158
ENSG00000215712 E006 298.928679 0.0008435509 3.755175e-10 2.361033e-08 6 157290232 157292743 2512 - 2.525 2.386 -0.463
ENSG00000215712 E007 328.532360 0.0005785698 1.401468e-01 3.477274e-01 6 157292744 157292999 256 - 2.527 2.495 -0.106
ENSG00000215712 E008 15.488490 0.0021205401 5.367018e-01 7.268488e-01 6 157318181 157318781 601 - 1.238 1.181 -0.205
ENSG00000215712 E009 222.838033 0.0002244549 1.272729e-05 2.586319e-04 6 157318782 157318919 138 - 2.305 2.397 0.307
ENSG00000215712 E010 179.552577 0.0003195433 1.187659e-02 6.592310e-02 6 157322705 157322805 101 - 2.227 2.286 0.198
ENSG00000215712 E011 7.420996 0.0048719005 8.013778e-01 8.971318e-01 6 157323002 157323301 300 - 0.949 0.917 -0.120
ENSG00000215712 E012 120.985746 0.0003664677 1.603835e-03 1.435935e-02 6 157323412 157323601 190 - 2.042 2.136 0.316