ENSG00000214765

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000413875 ENSG00000214765 HEK293_OSMI2_6hA HEK293_TMG_6hB SEPTIN7P2 transcribed_unprocessed_pseudogene retained_intron 9.053512 5.639906 12.9272 1.275494 1.4778 1.195226 0.4708661 0.4590904 0.7801433 0.1494409 0.3085859 0.7522484 0.05223333 0.07796667 0.05703333 -0.020933333 0.8260576265 0.0002996265   FALSE
ENST00000428414 ENSG00000214765 HEK293_OSMI2_6hA HEK293_TMG_6hB SEPTIN7P2 transcribed_unprocessed_pseudogene processed_transcript 9.053512 5.639906 12.9272 1.275494 1.4778 1.195226 0.4335605 0.2012710 0.7211265 0.2012710 0.3660217 1.7910265 0.05053333 0.04163333 0.05010000 0.008466667 0.8170492164 0.0002996265   FALSE
ENST00000429741 ENSG00000214765 HEK293_OSMI2_6hA HEK293_TMG_6hB SEPTIN7P2 transcribed_unprocessed_pseudogene processed_transcript 9.053512 5.639906 12.9272 1.275494 1.4778 1.195226 1.2645199 1.1710199 1.2951536 0.3394955 0.4428933 0.1441864 0.15013333 0.20170000 0.09430000 -0.107400000 0.3067476379 0.0002996265   FALSE
ENST00000686085 ENSG00000214765 HEK293_OSMI2_6hA HEK293_TMG_6hB SEPTIN7P2 transcribed_unprocessed_pseudogene processed_transcript 9.053512 5.639906 12.9272 1.275494 1.4778 1.195226 1.8937648 0.2966153 3.6059196 0.2966153 0.2762298 3.5598612 0.19495833 0.07513333 0.29263333 0.217500000 0.2392598637 0.0002996265   FALSE
ENST00000689506 ENSG00000214765 HEK293_OSMI2_6hA HEK293_TMG_6hB SEPTIN7P2 transcribed_unprocessed_pseudogene processed_transcript 9.053512 5.639906 12.9272 1.275494 1.4778 1.195226 0.5461906 0.0000000 1.3702649 0.0000000 0.4040109 7.1088013 0.05183750 0.00000000 0.11416667 0.114166667 0.0002996265 0.0002996265   FALSE
ENST00000690171 ENSG00000214765 HEK293_OSMI2_6hA HEK293_TMG_6hB SEPTIN7P2 transcribed_unprocessed_pseudogene processed_transcript 9.053512 5.639906 12.9272 1.275494 1.4778 1.195226 0.3540907 0.4960842 0.0000000 0.2655108 0.0000000 -5.6613055 0.04150833 0.08616667 0.00000000 -0.086166667 0.1923796601 0.0002996265   FALSE
ENST00000691119 ENSG00000214765 HEK293_OSMI2_6hA HEK293_TMG_6hB SEPTIN7P2 transcribed_unprocessed_pseudogene processed_transcript 9.053512 5.639906 12.9272 1.275494 1.4778 1.195226 1.2291971 0.9089803 1.2508797 0.1944185 0.6897859 0.4563248 0.13565833 0.16626667 0.08816667 -0.078100000 0.7605036293 0.0002996265 FALSE FALSE
MSTRG.29831.8 ENSG00000214765 HEK293_OSMI2_6hA HEK293_TMG_6hB SEPTIN7P2 transcribed_unprocessed_pseudogene   9.053512 5.639906 12.9272 1.275494 1.4778 1.195226 0.8405544 0.7859127 1.0623954 0.2778764 0.4673200 0.4301549 0.10093750 0.13476667 0.07630000 -0.058466667 0.7380576355 0.0002996265   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000214765 E001 0.3032425 0.0244411696 0.108909089   7 45723780 45723783 4 - 0.000 0.271 13.087
ENSG00000214765 E002 0.3032425 0.0244411696 0.108909089   7 45723784 45723786 3 - 0.000 0.271 13.092
ENSG00000214765 E003 0.3032425 0.0244411696 0.108909089   7 45723787 45723787 1 - 0.000 0.271 13.092
ENSG00000214765 E004 0.5059767 0.0217681645 0.036427610   7 45723788 45723797 10 - 0.000 0.362 13.679
ENSG00000214765 E005 9.0196074 0.1733092008 0.727039920 0.85244477 7 45723798 45723919 122 - 0.963 1.036 0.269
ENSG00000214765 E006 21.9606677 0.3341996244 0.298339772 0.53877108 7 45723920 45724023 104 - 1.253 1.473 0.765
ENSG00000214765 E007 16.9562966 0.1739955902 0.029046033 0.12449052 7 45724050 45724352 303 - 1.003 1.479 1.685
ENSG00000214765 E008 25.5142941 0.3291234096 0.139044745 0.34605166 7 45724353 45724480 128 - 1.264 1.585 1.109
ENSG00000214765 E009 11.3199117 0.1448195416 0.061914992 0.20711950 7 45724481 45724569 89 - 0.899 1.290 1.417
ENSG00000214765 E010 20.4271674 0.3442929375 0.189918493 0.41684292 7 45724570 45724717 148 - 1.144 1.515 1.295
ENSG00000214765 E011 50.5833583 0.5169642062 0.118943177 0.31413155 7 45724718 45725715 998 - 1.483 1.922 1.489
ENSG00000214765 E012 10.6850712 0.1536233670 0.193725908 0.42176217 7 45726045 45726183 139 - 0.929 1.210 1.022
ENSG00000214765 E013 15.1731098 0.1972361922 0.039762288 0.15412209 7 45726184 45726236 53 - 0.996 1.408 1.464
ENSG00000214765 E014 6.7707255 0.1601113891 0.230108245 0.46526456 7 45726237 45726330 94 - 0.739 1.055 1.204
ENSG00000214765 E015 2.9956230 0.0984344632 0.384055820 0.61562427 7 45726331 45726332 2 - 0.498 0.727 1.015
ENSG00000214765 E016 65.9494130 0.7145873109 0.326150385 0.56532045 7 45726333 45726861 529 - 1.722 1.930 0.702
ENSG00000214765 E017 26.2770707 0.3519782630 0.177618476 0.40059634 7 45726862 45727318 457 - 1.292 1.583 1.002
ENSG00000214765 E018 15.4168957 0.2927224132 0.426597143 0.64850680 7 45727827 45727846 20 - 1.139 1.290 0.532
ENSG00000214765 E019 18.2918107 0.3906595882 0.463601515 0.67553549 7 45727847 45727909 63 - 1.213 1.353 0.491
ENSG00000214765 E020 14.6150214 0.2820182197 0.631093802 0.79110562 7 45727910 45727992 83 - 1.161 1.208 0.169
ENSG00000214765 E021 10.0726557 0.1570628280 0.452375650 0.66744097 7 45727993 45728056 64 - 0.968 1.131 0.595
ENSG00000214765 E022 9.6395406 0.2368876198 0.884553801 0.94370225 7 45728057 45728177 121 - 0.998 1.044 0.169
ENSG00000214765 E023 56.4094591 0.6858875233 0.413249959 0.63853973 7 45728178 45728313 136 - 1.687 1.825 0.466
ENSG00000214765 E024 1.1909328 0.0153787590 0.842329132   7 45728605 45728831 227 - 0.292 0.363 0.446
ENSG00000214765 E025 10.8395110 0.0038708213 0.121681134 0.31851926 7 45728832 45729026 195 - 0.983 1.197 0.774
ENSG00000214765 E026 59.6211881 0.0007475386 0.031187493 0.13089051 7 45736787 45736910 124 - 1.786 1.749 -0.123
ENSG00000214765 E027 0.7007164 0.6943479034 0.873678151   7 45739380 45739515 136 - 0.175 0.277 0.841
ENSG00000214765 E028 40.6258608 0.0339457504 0.122051088 0.31911838 7 45744997 45745048 52 - 1.634 1.544 -0.308
ENSG00000214765 E029 4.7535261 0.0059165320 0.422142491 0.64526662 7 45746827 45746948 122 - 0.684 0.850 0.666
ENSG00000214765 E030 50.8594999 0.0777311552 0.048060166 0.17512545 7 45747215 45747311 97 - 1.761 1.562 -0.678
ENSG00000214765 E031 49.4241479 0.0953498397 0.141488594 0.34971762 7 45748626 45748714 89 - 1.735 1.585 -0.509
ENSG00000214765 E032 51.7123059 0.0356805935 0.005749985 0.03849561 7 45751529 45751646 118 - 1.771 1.562 -0.709
ENSG00000214765 E033 43.8037904 0.0332527081 0.028638658 0.12328896 7 45756909 45756992 84 - 1.681 1.537 -0.493
ENSG00000214765 E034 0.5008152 0.0644973806 0.192493354   7 45757984 45758042 59 - 0.236 0.000 -12.001
ENSG00000214765 E035 39.5842539 0.0398501160 0.022743886 0.10510027 7 45758043 45758110 68 - 1.641 1.484 -0.537
ENSG00000214765 E036 40.3268295 0.0593696744 0.097942420 0.27817895 7 45758111 45758177 67 - 1.632 1.531 -0.347
ENSG00000214765 E037 34.0284441 0.0692825263 0.069572906 0.22390597 7 45759074 45759174 101 - 1.576 1.421 -0.533
ENSG00000214765 E038 2.9495712 0.1398169603 0.837079238 0.91781197 7 45759175 45759472 298 - 0.558 0.615 0.254
ENSG00000214765 E039 2.1056726 0.0101650052 0.536921792 0.72697582 7 45765706 45765812 107 - 0.499 0.438 -0.310
ENSG00000214765 E040 31.9675388 0.0776421344 0.187738537 0.41403462 7 45768660 45769042 383 - 1.536 1.433 -0.353