ENSG00000214293

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000687769 ENSG00000214293 HEK293_OSMI2_6hA HEK293_TMG_6hB APTR lncRNA lncRNA 11.58561 8.37533 14.42534 1.142147 0.5208418 0.7836654 0.8473724 1.462885 0.1599943 0.3290485 0.1599943 -3.1150865 0.0828250 0.1722000 0.01183333 -0.16036667 0.04709975 0.04709975   FALSE
ENST00000687850 ENSG00000214293 HEK293_OSMI2_6hA HEK293_TMG_6hB APTR lncRNA lncRNA 11.58561 8.37533 14.42534 1.142147 0.5208418 0.7836654 4.1264746 1.892496 6.2156206 0.5315499 0.4751079 1.7103242 0.3496208 0.2281000 0.43023333 0.20213333 0.17077149 0.04709975   FALSE
ENST00000690779 ENSG00000214293 HEK293_OSMI2_6hA HEK293_TMG_6hB APTR lncRNA lncRNA 11.58561 8.37533 14.42534 1.142147 0.5208418 0.7836654 2.4880588 1.872322 2.8533016 0.2521911 0.2691889 0.6051663 0.2112167 0.2263667 0.19940000 -0.02696667 0.89162458 0.04709975 TRUE FALSE
MSTRG.30129.16 ENSG00000214293 HEK293_OSMI2_6hA HEK293_TMG_6hB APTR lncRNA   11.58561 8.37533 14.42534 1.142147 0.5208418 0.7836654 1.7883358 1.915801 2.3283068 0.4502789 0.8169447 0.2800054 0.1578458 0.2226000 0.16143333 -0.06116667 0.75241253 0.04709975   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000214293 E001 0.0000000       7 77657659 77657659 1 -      
ENSG00000214293 E002 0.2027342 0.073444197 0.354251274   7 77657660 77657694 35 - 0.000 0.142 9.738
ENSG00000214293 E003 0.2027342 0.073444197 0.354251274   7 77657695 77657696 2 - 0.000 0.142 11.990
ENSG00000214293 E004 0.2027342 0.073444197 0.354251274   7 77657697 77657732 36 - 0.000 0.142 11.990
ENSG00000214293 E005 22.3454798 0.108680871 0.213098593 0.44538285 7 77657733 77659075 1343 - 1.437 1.234 -0.707
ENSG00000214293 E006 6.2358429 0.009383726 0.470141026 0.68017310 7 77659076 77659249 174 - 0.890 0.805 -0.327
ENSG00000214293 E007 4.6659570 0.035816637 0.627648782 0.78897377 7 77659250 77659318 69 - 0.724 0.803 0.316
ENSG00000214293 E008 2.3757788 0.009624477 0.878582657 0.94056954 7 77661198 77661333 136 - 0.535 0.520 -0.074
ENSG00000214293 E009 2.0861557 0.063176935 0.012028741 0.06656533 7 77681581 77681606 26 - 0.628 0.142 -3.074
ENSG00000214293 E010 19.6395766 0.013348716 0.004563331 0.03227783 7 77681607 77683304 1698 - 1.395 1.138 -0.903
ENSG00000214293 E011 3.8354288 0.007209834 0.392350725 0.62227637 7 77683305 77683829 525 - 0.726 0.611 -0.490
ENSG00000214293 E012 0.4868358 0.306039859 0.822223688   7 77683830 77683850 21 - 0.191 0.139 -0.546
ENSG00000214293 E013 0.4868358 0.306039859 0.822223688   7 77683851 77683853 3 - 0.191 0.139 -0.546
ENSG00000214293 E014 12.4339150 0.030973098 0.582886997 0.75893248 7 77683854 77683942 89 - 1.147 1.084 -0.224
ENSG00000214293 E015 30.2452797 0.001749617 0.516809687 0.71292013 7 77683943 77684027 85 - 1.503 1.475 -0.096
ENSG00000214293 E016 42.2068624 0.002009710 0.159739331 0.37641123 7 77684028 77684089 62 - 1.659 1.596 -0.217
ENSG00000214293 E017 101.7293071 0.004302289 0.852880069 0.92661155 7 77684090 77684251 162 - 2.005 2.015 0.032
ENSG00000214293 E018 9.9921096 0.003382404 0.599216811 0.76967103 7 77684252 77684333 82 - 1.052 1.010 -0.154
ENSG00000214293 E019 13.2983773 0.002863070 0.883813191 0.94325581 7 77684334 77684784 451 - 1.145 1.171 0.093
ENSG00000214293 E020 8.0859834 0.004083057 0.911057515 0.95769512 7 77684785 77685201 417 - 0.959 0.958 -0.004
ENSG00000214293 E021 82.7405713 0.001898675 0.291534468 0.53216306 7 77685202 77685328 127 - 1.934 1.906 -0.093
ENSG00000214293 E022 62.1553861 0.001896431 0.285493311 0.52608351 7 77695896 77696018 123 - 1.816 1.779 -0.124
ENSG00000214293 E023 44.7619090 0.001110521 0.996612230 0.99998628 7 77696019 77696117 99 - 1.651 1.663 0.042
ENSG00000214293 E024 30.0739848 0.001681410 0.036531081 0.14567056 7 77696118 77696171 54 - 1.422 1.566 0.496
ENSG00000214293 E025 28.1191652 0.001819330 0.004653617 0.03275547 7 77696172 77696277 106 - 1.365 1.562 0.677
ENSG00000214293 E026 20.6657925 0.171646977 0.009112422 0.05432108 7 77696456 77696889 434 - 1.040 1.558 1.817
ENSG00000214293 E027 8.9635838 0.167469542 0.046821622 0.17211542 7 77696890 77697064 175 - 0.778 1.196 1.559