ENSG00000214193

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373137 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding processed_transcript 2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.1544557 0.27223306 0.1700647 0.272233058 0.17006471 -0.6483716 0.06061250 0.13920000 0.09053333 -0.04866667 0.962181529 0.005057345   FALSE
ENST00000453908 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding protein_coding 2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.1358271 0.08779864 0.1478779 0.003926825 0.04035350 0.6909225 0.06024583 0.03233333 0.08833333 0.05600000 0.347557836 0.005057345 FALSE TRUE
ENST00000480549 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding nonsense_mediated_decay 2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.1504654 0.23129508 0.1650418 0.071033579 0.08649307 -0.4630987 0.06799583 0.09786667 0.09746667 -0.00040000 1.000000000 0.005057345 TRUE TRUE
ENST00000496636 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding processed_transcript 2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.1777724 0.19350954 0.0000000 0.115950620 0.00000000 -4.3470245 0.07122917 0.05190000 0.00000000 -0.05190000 0.257034106 0.005057345 FALSE FALSE
ENST00000505871 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding protein_coding 2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.6532337 1.02643429 0.4051507 0.332260188 0.01281016 -1.3199217 0.25565000 0.32633333 0.24540000 -0.08093333 0.697098818 0.005057345 FALSE TRUE
ENST00000508854 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding processed_transcript 2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.1687648 0.00000000 0.1609131 0.000000000 0.16091306 4.0951907 0.07989583 0.00000000 0.10153333 0.10153333 0.811966832 0.005057345 FALSE TRUE
ENST00000672313 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding processed_transcript 2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.5674919 0.55761118 0.1100464 0.557611177 0.11004641 -2.2413108 0.21333333 0.11283333 0.06943333 -0.04340000 1.000000000 0.005057345   FALSE
ENST00000672976 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding nonsense_mediated_decay 2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.0219815 0.00000000 0.1758520 0.000000000 0.17585202 4.2160824 0.01450417 0.00000000 0.11603333 0.11603333 0.812915876 0.005057345 TRUE FALSE
MSTRG.847.2 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding   2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.1221519 0.28446245 0.0000000 0.038922572 0.00000000 -4.8800118 0.04970000 0.10266667 0.00000000 -0.10266667 0.005057345 0.005057345 TRUE TRUE
MSTRG.847.5 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding   2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.1372736 0.12656175 0.3246672 0.126561746 0.16513442 1.2931739 0.05725833 0.02560000 0.19133333 0.16573333 0.598827366 0.005057345 FALSE TRUE
MSTRG.847.6 ENSG00000214193 HEK293_OSMI2_6hA HEK293_TMG_6hB SH3D21 protein_coding   2.456072 3.101361 1.659614 0.9294203 0.1112876 -0.8980313 0.1584419 0.32145491 0.0000000 0.187826760 0.00000000 -5.0507407 0.06532500 0.11126667 0.00000000 -0.11126667 0.379573885 0.005057345 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000214193 E001 0.7970432 0.017203968 0.008463888   1 36306368 36306424 57 + 0.515 0.073 -3.637
ENSG00000214193 E002 1.2617014 0.013143284 0.020272094   1 36306598 36306755 158 + 0.585 0.190 -2.375
ENSG00000214193 E003 1.2497472 0.014355184 0.383495985   1 36306842 36306905 64 + 0.433 0.282 -0.904
ENSG00000214193 E004 0.0000000       1 36307109 36307109 1 +      
ENSG00000214193 E005 0.2027342 0.264706155 1.000000000   1 36307110 36307116 7 + 0.000 0.074 9.190
ENSG00000214193 E006 0.9585609 0.639565351 0.920857514   1 36307117 36307118 2 + 0.199 0.255 0.461
ENSG00000214193 E007 1.7374203 0.023334137 0.278768526 0.51886361 1 36307119 36307127 9 + 0.196 0.424 1.536
ENSG00000214193 E008 4.9810451 0.024823473 0.841905840 0.92052470 1 36307128 36307166 39 + 0.744 0.716 -0.115
ENSG00000214193 E009 9.9133245 0.004407380 0.336684943 0.57510407 1 36307167 36307285 119 + 1.051 0.956 -0.349
ENSG00000214193 E010 9.8742146 0.009937803 0.481237544 0.68790976 1 36307517 36307607 91 + 1.028 0.957 -0.262
ENSG00000214193 E011 8.7543325 0.004556399 0.404902225 0.63219545 1 36307770 36307825 56 + 0.826 0.956 0.498
ENSG00000214193 E012 6.1844000 0.010422877 0.498702420 0.69990498 1 36307918 36307963 46 + 0.698 0.824 0.510
ENSG00000214193 E013 4.6472704 0.006636292 0.087607449 0.25927121 1 36308109 36308209 101 + 0.861 0.632 -0.930
ENSG00000214193 E014 11.8442773 0.035297546 0.077700967 0.24019170 1 36308389 36308475 87 + 1.184 1.001 -0.663
ENSG00000214193 E015 0.3447487 0.062900419 0.820756188   1 36309511 36309547 37 + 0.000 0.136 10.168
ENSG00000214193 E016 10.6814282 0.003132722 0.023974436 0.10900114 1 36309548 36309590 43 + 1.166 0.947 -0.798
ENSG00000214193 E017 0.2027342 0.264706155 1.000000000   1 36309591 36309592 2 + 0.000 0.074 9.190
ENSG00000214193 E018 10.3953014 0.003024534 0.031576090 0.13199297 1 36319071 36319131 61 + 1.149 0.938 -0.770
ENSG00000214193 E019 7.9784147 0.003760505 0.004181869 0.03017282 1 36319132 36319164 33 + 1.112 0.799 -1.173
ENSG00000214193 E020 6.5739613 0.004886118 0.080237534 0.24528692 1 36319260 36319312 53 + 0.979 0.773 -0.790
ENSG00000214193 E021 6.5913437 0.005075006 0.170140288 0.39064323 1 36319442 36319536 95 + 0.645 0.869 0.907
ENSG00000214193 E022 22.0227414 0.003412543 0.290955204 0.53156136 1 36319675 36320039 365 + 1.344 1.278 -0.231
ENSG00000214193 E023 35.9489831 0.009275575 0.043717517 0.16440950 1 36320040 36320603 564 + 1.599 1.469 -0.445
ENSG00000214193 E024 21.2056795 0.002374041 0.020883415 0.09897257 1 36320604 36320798 195 + 1.406 1.241 -0.575
ENSG00000214193 E025 10.9406733 0.018379188 0.784073303 0.88692845 1 36320915 36320978 64 + 0.980 1.039 0.216
ENSG00000214193 E026 8.3961114 0.012094453 0.837172449 0.91786084 1 36321056 36321129 74 + 0.894 0.936 0.160
ENSG00000214193 E027 6.7229047 0.004682934 0.749978033 0.86676669 1 36321130 36321209 80 + 0.787 0.847 0.236
ENSG00000214193 E028 17.9831618 0.002146902 0.315786553 0.55579206 1 36321210 36321723 514 + 1.271 1.204 -0.236
ENSG00000214193 E029 12.6756358 0.012580924 0.754508452 0.86942256 1 36321724 36321778 55 + 1.029 1.095 0.239
ENSG00000214193 E030 21.7761042 0.002160390 0.011673968 0.06512625 1 36321779 36322363 585 + 1.093 1.350 0.908
ENSG00000214193 E031 4.2256280 0.048092911 0.040169342 0.15513334 1 36322364 36322366 3 + 0.330 0.742 1.991
ENSG00000214193 E032 11.9701411 0.026787674 0.081748211 0.24830489 1 36322367 36322664 298 + 0.860 1.098 0.886
ENSG00000214193 E033 22.2141251 0.002205666 0.001051322 0.01030467 1 36322665 36323733 1069 + 1.028 1.364 1.194
ENSG00000214193 E034 2.3256194 0.011963320 0.090959668 0.26543656 1 36323734 36323769 36 + 0.196 0.551 2.165
ENSG00000214193 E035 6.7962956 0.005813066 0.051223659 0.18263989 1 36323770 36323939 170 + 0.585 0.900 1.285
ENSG00000214193 E036 10.4135962 0.003241692 0.111252047 0.30105783 1 36323940 36324069 130 + 0.825 1.044 0.821
ENSG00000214193 E037 25.8181115 0.116220813 0.363862444 0.59892008 1 36324070 36324977 908 + 1.259 1.394 0.470
ENSG00000214193 E038 9.8208505 0.024883053 0.334958002 0.57353296 1 36326297 36326547 251 + 0.861 1.011 0.567
ENSG00000214193 E039 48.5224170 0.336863501 0.269658139 0.50954863 1 36327720 36329340 1621 + 1.475 1.666 0.653