ENSG00000214026

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381519 ENSG00000214026 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPL23 protein_coding protein_coding 377.3182 609.0413 135.7621 151.7257 6.235047 -2.165376 56.83472 77.01257 61.28505 14.14397 9.999588 -0.3295107 0.1989458 0.1327000 0.4500 0.3173000 0.0002970379 0.0002970379 FALSE TRUE
ENST00000397298 ENSG00000214026 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPL23 protein_coding protein_coding 377.3182 609.0413 135.7621 151.7257 6.235047 -2.165376 311.08582 517.28828 67.51592 138.00266 10.223570 -2.9374831 0.7683583 0.8386667 0.4986 -0.3400667 0.0022239214 0.0002970379 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000214026 E001 0.2617363 0.0411787298 1.000000e+00   11 1947278 1947331 54 + 0.000 0.101 8.888
ENSG00000214026 E002 1.3934116 0.0157603951 2.056868e-01 4.366731e-01 11 1947332 1947340 9 + 0.000 0.339 12.393
ENSG00000214026 E003 6.0609955 0.0052446919 2.979528e-01 5.384326e-01 11 1947341 1947343 3 + 0.865 0.705 -0.638
ENSG00000214026 E004 30.3049097 0.0013773838 7.630236e-01 8.744581e-01 11 1947344 1947379 36 + 1.334 1.357 0.082
ENSG00000214026 E005 0.5227326 0.6957740923 4.834160e-01   11 1947554 1947578 25 + 0.257 0.104 -1.584
ENSG00000214026 E006 0.3336024 0.0244411696 1.000000e+00   11 1949540 1950161 622 + 0.000 0.101 10.124
ENSG00000214026 E007 37.3596725 0.0009830826 7.561951e-01 8.703445e-01 11 1950899 1950909 11 + 1.420 1.442 0.074
ENSG00000214026 E008 143.0514226 0.0003595855 2.487523e-01 4.865016e-01 11 1950910 1951021 112 + 1.967 2.012 0.150
ENSG00000214026 E009 338.2479932 0.0018003602 4.378721e-01 6.571178e-01 11 1952127 1952209 83 + 2.402 2.368 -0.114
ENSG00000214026 E010 598.9474210 0.0007629405 9.541271e-05 1.437840e-03 11 1952782 1952855 74 + 2.697 2.608 -0.294
ENSG00000214026 E011 1.7084206 0.0114971628 6.092360e-01 7.763941e-01 11 1952856 1953011 156 + 0.253 0.364 0.731
ENSG00000214026 E012 13.9886171 0.0922697260 2.619980e-01 5.011126e-01 11 1953012 1953322 311 + 1.227 0.990 -0.854
ENSG00000214026 E013 0.0000000       11 1955577 1955610 34 +      
ENSG00000214026 E014 11.8747971 0.0264256599 2.308820e-02 1.062321e-01 11 1955611 1955717 107 + 1.224 0.917 -1.119
ENSG00000214026 E015 4.9751956 0.0127735910 2.729611e-01 5.128026e-01 11 1955718 1955781 64 + 0.816 0.630 -0.761
ENSG00000214026 E016 1272.2644280 0.0003729154 5.502002e-01 7.364131e-01 11 1956256 1956448 193 + 2.963 2.948 -0.048
ENSG00000214026 E017 127.6911694 0.0017817967 1.424317e-08 6.457067e-07 11 1956449 1956541 93 + 1.678 1.992 1.059
ENSG00000214026 E018 253.8810315 0.0002426612 3.916778e-08 1.602407e-06 11 1956542 1956609 68 + 2.095 2.277 0.607
ENSG00000214026 E019 0.1308682 0.0326491905 9.496355e-01   11 1962239 1962838 600 + 0.000 0.054 9.041
ENSG00000214026 E020 0.9937403 0.2697256343 2.855726e-01   11 1972559 1972758 200 + 0.415 0.209 -1.374
ENSG00000214026 E021 0.0000000       11 1972759 1972793 35 +      
ENSG00000214026 E022 0.1308682 0.0326491905 9.496355e-01   11 1984438 1984522 85 + 0.000 0.054 9.041