ENSG00000213742

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000414393 ENSG00000213742 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF337-AS1 lncRNA lncRNA 2.722756 3.461178 1.6227 0.512221 0.4762428 -1.088165 0.14575947 0.31438448 0.075402909 0.04665108 0.038022485 -1.9253477 0.06110000 0.100566667 0.066433333 -0.03413333 0.832951824 0.001891767   FALSE
ENST00000428254 ENSG00000213742 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF337-AS1 lncRNA lncRNA 2.722756 3.461178 1.6227 0.512221 0.4762428 -1.088165 0.15689475 0.15409648 0.006038239 0.07718225 0.006038239 -3.3549567 0.05553750 0.038900000 0.006533333 -0.03236667 0.707115071 0.001891767 FALSE FALSE
ENST00000455791 ENSG00000213742 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF337-AS1 lncRNA lncRNA 2.722756 3.461178 1.6227 0.512221 0.4762428 -1.088165 0.26627910 0.18319375 0.216224390 0.06355572 0.055649985 0.2277061 0.10561667 0.050533333 0.168766667 0.11823333 0.449887280 0.001891767   FALSE
ENST00000661376 ENSG00000213742 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF337-AS1 lncRNA lncRNA 2.722756 3.461178 1.6227 0.512221 0.4762428 -1.088165 0.10766283 0.02488804 0.439075352 0.02488804 0.338518943 3.6861531 0.04478333 0.010166667 0.199000000 0.18883333 0.196559544 0.001891767 FALSE FALSE
MSTRG.20515.1 ENSG00000213742 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF337-AS1 lncRNA   2.722756 3.461178 1.6227 0.512221 0.4762428 -1.088165 0.12570372 0.10899913 0.221012221 0.05455571 0.049778019 0.9570182 0.05942500 0.036266667 0.156533333 0.12026667 0.358900916 0.001891767   FALSE
MSTRG.20515.4 ENSG00000213742 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF337-AS1 lncRNA   2.722756 3.461178 1.6227 0.512221 0.4762428 -1.088165 1.30863418 2.29756518 0.275538336 0.63345245 0.140591500 -3.0146150 0.45167500 0.633933333 0.157133333 -0.47680000 0.140742987 0.001891767   FALSE
MSTRG.20515.7 ENSG00000213742 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF337-AS1 lncRNA   2.722756 3.461178 1.6227 0.512221 0.4762428 -1.088165 0.06945124 0.02010289 0.251184747 0.02010289 0.082751116 3.1170968 0.03308750 0.005233333 0.161633333 0.15640000 0.001891767 0.001891767 FALSE FALSE
MSTRG.20515.8 ENSG00000213742 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF337-AS1 lncRNA   2.722756 3.461178 1.6227 0.512221 0.4762428 -1.088165 0.21902045 0.06959470 0.054257024 0.03480953 0.054257024 -0.3088182 0.07120833 0.023200000 0.038466667 0.01526667 1.000000000 0.001891767   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000213742 E001 1.9138970 0.025502263 1.044326e-01 2.896324e-01 20 25624036 25624044 9 + 0.687 0.270 -2.164
ENSG00000213742 E002 3.9383221 0.035260635 3.659057e-01 6.006799e-01 20 25624045 25624058 14 + 0.861 0.554 -1.278
ENSG00000213742 E003 5.4635974 0.064661423 6.837512e-01 8.251168e-01 20 25624059 25624074 16 + 0.938 0.703 -0.925
ENSG00000213742 E004 6.4949521 0.095561172 9.986438e-01 1.000000e+00 20 25624075 25624089 15 + 0.961 0.787 -0.668
ENSG00000213742 E005 7.9420117 0.102022975 8.876762e-01 9.454357e-01 20 25624090 25624110 21 + 1.024 0.870 -0.577
ENSG00000213742 E006 7.8909518 0.183078134 7.867794e-01 8.886000e-01 20 25624111 25624135 25 + 1.004 0.878 -0.472
ENSG00000213742 E007 0.7204775 0.194577255 5.016215e-01   20 25624157 25624232 76 + 0.170 0.222 0.472
ENSG00000213742 E008 1.0313547 0.301205472 2.878784e-01   20 25624233 25624426 194 + 0.171 0.322 1.181
ENSG00000213742 E009 0.2735028 0.028475850 8.190383e-01   20 25624427 25624446 20 + 0.171 0.085 -1.167
ENSG00000213742 E010 1.1845155 0.053732869 1.305936e-01   20 25632158 25632189 32 + 0.171 0.362 1.427
ENSG00000213742 E011 1.0230998 0.052613350 2.478922e-02   20 25632190 25632209 20 + 0.000 0.362 18.439
ENSG00000213742 E012 2.0166476 0.220711658 2.391309e-01 4.756041e-01 20 25632210 25632288 79 + 0.292 0.507 1.202
ENSG00000213742 E013 9.2512726 0.060215500 4.676067e-02 1.719621e-01 20 25634049 25634102 54 + 0.890 1.016 0.473
ENSG00000213742 E014 12.4818905 0.041246944 1.083215e-02 6.165905e-02 20 25634103 25634170 68 + 0.986 1.144 0.573
ENSG00000213742 E015 15.6685384 0.108870058 6.945812e-02 2.236851e-01 20 25634729 25634827 99 + 1.098 1.226 0.456
ENSG00000213742 E016 2.7069577 0.008299660 3.191227e-02 1.329565e-01 20 25639729 25639820 92 + 0.389 0.603 1.056
ENSG00000213742 E017 6.0892681 0.124639767 4.637838e-01 6.757019e-01 20 25645531 25645648 118 + 0.829 0.820 -0.037
ENSG00000213742 E018 1.2150630 0.521088099 6.747431e-01   20 25670111 25670344 234 + 0.295 0.329 0.220
ENSG00000213742 E019 11.0880603 0.005541751 5.693595e-08 2.240995e-06 20 25673852 25674007 156 + 0.687 1.150 1.765
ENSG00000213742 E020 11.9461843 0.247277985 2.909247e-02 1.246327e-01 20 25674008 25674896 889 + 0.756 1.170 1.552
ENSG00000213742 E021 10.7942197 0.356292365 1.709529e-01 3.918177e-01 20 25674897 25675078 182 + 0.922 1.085 0.600
ENSG00000213742 E022 12.9118529 0.363896919 1.273488e-01 3.276581e-01 20 25675079 25676080 1002 + 0.924 1.173 0.912
ENSG00000213742 E023 2.8750077 0.145520363 3.823203e-02 1.501892e-01 20 25676081 25676248 168 + 0.294 0.633 1.769
ENSG00000213742 E024 2.2360698 0.036639906 3.839633e-04 4.578737e-03 20 25676249 25676332 84 + 0.000 0.603 19.651
ENSG00000213742 E025 2.5881635 0.198851399 1.961287e-01 4.246951e-01 20 25676333 25676416 84 + 0.388 0.593 1.016
ENSG00000213742 E026 4.8138949 0.110594688 4.115274e-02 1.577403e-01 20 25676417 25676935 519 + 0.532 0.812 1.189
ENSG00000213742 E027 14.3533398 0.122724327 9.166038e-01 9.604676e-01 20 25676936 25678207 1272 + 1.267 1.097 -0.607
ENSG00000213742 E028 2.7487242 0.008065284 5.509503e-01 7.370036e-01 20 25683097 25683223 127 + 0.591 0.527 -0.293
ENSG00000213742 E029 6.2691915 0.650658766 3.878160e-01 6.187705e-01 20 25687830 25688055 226 + 1.226 0.361 -3.610
ENSG00000213742 E030 2.1087093 0.010914137 1.858657e-04 2.516685e-03 20 25688700 25688702 3 + 0.833 0.085 -4.753
ENSG00000213742 E031 83.4014193 0.266844539 2.913362e-02 1.247556e-01 20 25688703 25696039 7337 + 2.262 1.504 -2.556