ENSG00000213020

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000540744 ENSG00000213020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF611 protein_coding protein_coding 4.54188 4.602614 5.144496 0.2894535 0.6019256 0.1602469 0.62083551 0.56656777 1.2680116 0.03621820 0.18414348 1.14833884 0.14664583 0.12453333 0.24490000 0.12036667 6.637025e-02 2.472737e-05 FALSE TRUE
ENST00000596776 ENSG00000213020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF611 protein_coding retained_intron 4.54188 4.602614 5.144496 0.2894535 0.6019256 0.1602469 0.29738028 0.43416893 0.3413467 0.09541293 0.05655661 -0.33821322 0.06940000 0.09703333 0.07130000 -0.02573333 8.660384e-01 2.472737e-05   FALSE
ENST00000599798 ENSG00000213020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF611 protein_coding processed_transcript 4.54188 4.602614 5.144496 0.2894535 0.6019256 0.1602469 0.92770219 1.00554487 0.9656474 0.10575640 0.55225716 -0.05782221 0.19347917 0.21753333 0.16640000 -0.05113333 8.598261e-01 2.472737e-05   FALSE
ENST00000601447 ENSG00000213020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF611 protein_coding processed_transcript 4.54188 4.602614 5.144496 0.2894535 0.6019256 0.1602469 1.13505492 1.77863141 0.5013873 0.21536721 0.01524922 -1.80636786 0.24881667 0.38573333 0.10120000 -0.28453333 2.472737e-05 2.472737e-05   FALSE
ENST00000602162 ENSG00000213020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF611 protein_coding protein_coding 4.54188 4.602614 5.144496 0.2894535 0.6019256 0.1602469 0.08242401 0.00000000 0.2198704 0.00000000 0.21987037 4.52274859 0.02065000 0.00000000 0.05513333 0.05513333 9.044969e-01 2.472737e-05 FALSE TRUE
MSTRG.17624.11 ENSG00000213020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF611 protein_coding   4.54188 4.602614 5.144496 0.2894535 0.6019256 0.1602469 0.21141825 0.07846206 0.8559170 0.07846206 0.02573528 3.29109799 0.04581250 0.01786667 0.17016667 0.15230000 5.780921e-02 2.472737e-05   FALSE
MSTRG.17624.20 ENSG00000213020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF611 protein_coding   4.54188 4.602614 5.144496 0.2894535 0.6019256 0.1602469 0.46223578 0.56388682 0.0000000 0.28675721 0.00000000 -5.84269433 0.09329583 0.11766667 0.00000000 -0.11766667 3.014073e-01 2.472737e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000213020 E001 23.8610217 0.001816237 8.629277e-02 2.570024e-01 19 52702813 52703609 797 - 1.328 1.457 0.448
ENSG00000213020 E002 15.0499219 0.045033454 9.711894e-01 9.874292e-01 19 52703610 52704218 609 - 1.176 1.218 0.150
ENSG00000213020 E003 22.3138965 0.002081076 1.971334e-01 4.260127e-01 19 52704219 52704731 513 - 1.387 1.306 -0.282
ENSG00000213020 E004 72.1035975 0.003261495 2.609475e-05 4.782552e-04 19 52704732 52706459 1728 - 1.911 1.749 -0.549
ENSG00000213020 E005 6.6684931 0.018770772 9.125561e-03 5.438604e-02 19 52706460 52706610 151 - 0.982 0.624 -1.424
ENSG00000213020 E006 3.1572989 0.062746208 6.843460e-01 8.255153e-01 19 52706611 52706620 10 - 0.642 0.578 -0.279
ENSG00000213020 E007 3.4189856 0.011268200 2.251222e-01 4.595412e-01 19 52706621 52706621 1 - 0.712 0.532 -0.790
ENSG00000213020 E008 4.4611969 0.125529316 5.150136e-01 7.116560e-01 19 52706622 52706653 32 - 0.787 0.658 -0.526
ENSG00000213020 E009 2.8351579 0.214692472 6.715678e-01 8.172802e-01 19 52706654 52706655 2 - 0.633 0.521 -0.507
ENSG00000213020 E010 4.0260907 0.021162462 6.113038e-01 7.777954e-01 19 52706656 52706709 54 - 0.733 0.662 -0.292
ENSG00000213020 E011 5.5691857 0.005734492 3.035130e-01 5.440635e-01 19 52706710 52706776 67 - 0.859 0.733 -0.501
ENSG00000213020 E012 5.6533861 0.005402414 6.263022e-02 2.086649e-01 19 52706777 52706864 88 - 0.904 0.663 -0.962
ENSG00000213020 E013 0.8925621 0.019995202 7.414468e-01   19 52707392 52707420 29 - 0.309 0.255 -0.375
ENSG00000213020 E014 1.3877679 0.014310716 6.836157e-01 8.249859e-01 19 52707421 52707468 48 - 0.408 0.343 -0.376
ENSG00000213020 E015 3.1680929 0.008303369 6.139529e-02 2.058994e-01 19 52707469 52707538 70 - 0.712 0.415 -1.376
ENSG00000213020 E016 2.0955217 0.009672942 8.891601e-03 5.332857e-02 19 52707539 52707542 4 - 0.615 0.146 -2.960
ENSG00000213020 E017 0.5173834 0.095611513 1.795546e-01   19 52708177 52708203 27 - 0.252 0.000 -11.267
ENSG00000213020 E018 0.1779838 0.040013084 7.080490e-01   19 52708204 52708326 123 - 0.100 0.000 -9.967
ENSG00000213020 E019 0.0000000       19 52708327 52708329 3 -      
ENSG00000213020 E020 0.0000000       19 52708421 52708831 411 -      
ENSG00000213020 E021 0.6841482 0.038582052 7.064597e-01   19 52711207 52711304 98 - 0.182 0.256 0.624
ENSG00000213020 E022 9.2376613 0.003241386 2.486990e-02 1.118329e-01 19 52714015 52714141 127 - 1.085 0.846 -0.895
ENSG00000213020 E023 7.1863792 0.004464238 1.517151e-03 1.373459e-02 19 52715832 52715913 82 - 1.026 0.623 -1.587
ENSG00000213020 E024 0.3040503 0.024441170 3.387595e-01   19 52716111 52716233 123 - 0.182 0.000 -10.953
ENSG00000213020 E025 13.4611856 0.041682738 1.349865e-09 7.679668e-08 19 52720909 52721152 244 - 0.642 1.465 3.057
ENSG00000213020 E026 4.3424123 0.008104760 5.116257e-04 5.783520e-03 19 52721153 52721182 30 - 0.450 0.954 2.134
ENSG00000213020 E027 8.1569151 0.030573538 1.372332e-05 2.757826e-04 19 52721183 52721263 81 - 0.616 1.217 2.306
ENSG00000213020 E028 4.2190614 0.025221858 1.106302e-03 1.071737e-02 19 52721264 52721267 4 - 0.450 0.952 2.128
ENSG00000213020 E029 4.0389773 0.040738105 1.000816e-02 5.820201e-02 19 52723421 52723870 450 - 0.451 0.896 1.915
ENSG00000213020 E030 3.3964079 0.011086247 2.949827e-02 1.258728e-01 19 52723871 52723989 119 - 0.450 0.794 1.519
ENSG00000213020 E031 7.1027831 0.006035151 3.691268e-03 2.743115e-02 19 52723990 52724664 675 - 0.713 1.073 1.378
ENSG00000213020 E032 14.3227202 0.016491356 7.137928e-01 8.442395e-01 19 52728730 52728831 102 - 1.160 1.201 0.147
ENSG00000213020 E033 0.1779838 0.040013084 7.080490e-01   19 52728924 52728944 21 - 0.100 0.000 -9.967
ENSG00000213020 E034 0.4764247 0.021768165 8.281449e-01   19 52729831 52729905 75 - 0.182 0.146 -0.375
ENSG00000213020 E035 7.9385335 0.005089357 8.760110e-01 9.392497e-01 19 52729906 52730005 100 - 0.944 0.935 -0.033
ENSG00000213020 E036 9.5390869 0.004015280 4.974777e-01 6.991613e-01 19 52735001 52735073 73 - 1.037 0.974 -0.232