ENSG00000205978

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382554 ENSG00000205978 HEK293_OSMI2_6hA HEK293_TMG_6hB NYNRIN protein_coding protein_coding 2.276009 3.464221 0.837639 0.3712942 0.03421983 -2.035168 1.4128729 1.966522 0.837639 0.1531421 0.03421983 -1.221442 0.7219083 0.5746 1 0.4254 5.660565e-07 5.660565e-07 FALSE TRUE
ENST00000554505 ENSG00000205978 HEK293_OSMI2_6hA HEK293_TMG_6hB NYNRIN protein_coding processed_transcript 2.276009 3.464221 0.837639 0.3712942 0.03421983 -2.035168 0.8631366 1.497699 0.000000 0.2873240 0.00000000 -7.236205 0.2780917 0.4254 0 -0.4254 5.834863e-07 5.660565e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000205978 E001 2.7838131 0.040955224 0.844893173 0.92207379 14 24399003 24399086 84 + 0.446 0.537 0.447
ENSG00000205978 E002 9.3638457 0.029063832 0.288813238 0.52943075 14 24399230 24399444 215 + 0.940 0.948 0.030
ENSG00000205978 E003 25.4135402 0.002893603 0.004966848 0.03445457 14 24407869 24408527 659 + 1.395 1.341 -0.188
ENSG00000205978 E004 67.3683401 0.076901010 0.016201287 0.08253146 14 24408652 24410208 1557 + 1.812 1.739 -0.245
ENSG00000205978 E005 14.6135714 0.005866343 0.232358654 0.46795822 14 24411076 24411206 131 + 1.091 1.127 0.131
ENSG00000205978 E006 13.3183012 0.006829596 0.837021483 0.91777828 14 24411354 24411450 97 + 0.971 1.110 0.510
ENSG00000205978 E007 0.8315845 0.525264228 0.306618504   14 24412594 24412691 98 + 0.348 0.182 -1.237
ENSG00000205978 E008 14.6844550 0.019961360 0.282210724 0.52256926 14 24412997 24413098 102 + 1.090 1.133 0.152
ENSG00000205978 E009 13.8528934 0.006016611 0.034612151 0.14054323 14 24413316 24413417 102 + 1.149 1.086 -0.227
ENSG00000205978 E010 269.7341152 1.089073967 0.266327677 0.50583881 14 24414596 24419283 4688 + 2.060 2.410 1.171