ENSG00000205758

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381554 ENSG00000205758 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZL1 protein_coding protein_coding 21.9752 7.18068 31.91276 0.5517348 1.386629 2.150385 2.6073489 0.9478043 3.503866 0.3369549 0.31474581 1.8752566 0.12533333 0.140233333 0.10940000 -0.03083333 0.985139753 0.000773567 FALSE TRUE
ENST00000413017 ENSG00000205758 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZL1 protein_coding protein_coding 21.9752 7.18068 31.91276 0.5517348 1.386629 2.150385 1.1564158 1.0809638 1.007368 0.2052777 0.10831226 -0.1007610 0.09318333 0.156033333 0.03143333 -0.12460000 0.002164923 0.000773567 FALSE TRUE
ENST00000431177 ENSG00000205758 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZL1 protein_coding protein_coding 21.9752 7.18068 31.91276 0.5517348 1.386629 2.150385 4.7954921 1.3697020 7.150398 0.2187017 0.94690144 2.3756831 0.19110833 0.188933333 0.22290000 0.03396667 0.839226349 0.000773567 FALSE FALSE
ENST00000437996 ENSG00000205758 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZL1 protein_coding nonsense_mediated_decay 21.9752 7.18068 31.91276 0.5517348 1.386629 2.150385 4.8897479 0.5419548 7.766472 0.5419548 0.81388711 3.8164938 0.18882083 0.083666667 0.24246667 0.15880000 0.278023790 0.000773567   FALSE
ENST00000440526 ENSG00000205758 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZL1 protein_coding protein_coding 21.9752 7.18068 31.91276 0.5517348 1.386629 2.150385 1.4159610 0.0455877 2.031896 0.0455877 0.40602098 5.1989996 0.05150833 0.007033333 0.06293333 0.05590000 0.066155175 0.000773567 FALSE TRUE
ENST00000468349 ENSG00000205758 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZL1 protein_coding retained_intron 21.9752 7.18068 31.91276 0.5517348 1.386629 2.150385 2.4089992 0.8451011 3.817313 0.6139532 0.09197506 2.1621649 0.11762500 0.106533333 0.11986667 0.01333333 0.839283575 0.000773567   FALSE
MSTRG.21293.1 ENSG00000205758 HEK293_OSMI2_6hA HEK293_TMG_6hB CRYZL1 protein_coding   21.9752 7.18068 31.91276 0.5517348 1.386629 2.150385 0.8023349 0.7561684 1.134306 0.2981737 0.23554051 0.5787391 0.04235833 0.103666667 0.03626667 -0.06740000 0.514590446 0.000773567 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000205758 E001 16.4645277 0.0639732275 2.011737e-02 9.628537e-02 21 33588782 33589033 252 - 1.054 1.431 1.331
ENSG00000205758 E002 7.2018792 0.0041477005 4.685370e-01 6.790441e-01 21 33589341 33589385 45 - 0.828 0.932 0.396
ENSG00000205758 E003 13.5329644 0.0026962220 5.753358e-01 7.539036e-01 21 33589386 33589460 75 - 1.108 1.059 -0.179
ENSG00000205758 E004 10.1389871 0.0030393626 3.487961e-01 5.862132e-01 21 33589461 33589466 6 - 1.006 0.901 -0.392
ENSG00000205758 E005 10.1389871 0.0030393626 3.487961e-01 5.862132e-01 21 33589467 33589467 1 - 1.006 0.901 -0.392
ENSG00000205758 E006 17.1723913 0.0018754420 5.054408e-01 7.045975e-01 21 33589468 33589544 77 - 1.210 1.157 -0.190
ENSG00000205758 E007 11.5935869 0.0030977496 3.321477e-01 5.710001e-01 21 33589545 33589559 15 - 1.063 0.960 -0.379
ENSG00000205758 E008 15.7827250 0.0025804727 1.547052e-01 3.690062e-01 21 33589560 33589616 57 - 1.196 1.059 -0.492
ENSG00000205758 E009 38.4810106 0.0019950631 4.725327e-02 1.731587e-01 21 33589617 33589768 152 - 1.556 1.425 -0.450
ENSG00000205758 E010 35.2487880 0.0013150292 3.866354e-03 2.839403e-02 21 33589769 33589805 37 - 1.534 1.329 -0.706
ENSG00000205758 E011 34.6903579 0.0021256694 1.171832e-01 3.111237e-01 21 33589806 33589840 35 - 1.510 1.405 -0.361
ENSG00000205758 E012 62.6599572 0.0007386605 2.180063e-02 1.019229e-01 21 33589841 33589921 81 - 1.762 1.649 -0.383
ENSG00000205758 E013 57.2067521 0.0042364731 2.360368e-02 1.078496e-01 21 33591162 33591207 46 - 1.725 1.589 -0.462
ENSG00000205758 E014 10.4421587 0.1569211228 3.377479e-01 5.760911e-01 21 33591208 33591211 4 - 1.025 0.877 -0.553
ENSG00000205758 E015 8.9797212 0.4267493503 6.105807e-01 7.773416e-01 21 33591212 33591228 17 - 0.920 0.980 0.225
ENSG00000205758 E016 18.8379779 0.2458789408 7.046707e-01 8.385076e-01 21 33591229 33591371 143 - 1.209 1.300 0.322
ENSG00000205758 E017 25.1568851 0.2367647742 5.176567e-01 7.133931e-01 21 33591372 33591718 347 - 1.347 1.369 0.078
ENSG00000205758 E018 5.2899011 0.0053815141 9.789147e-01 9.912449e-01 21 33594507 33594642 136 - 0.739 0.752 0.053
ENSG00000205758 E019 3.7263623 0.0069756416 7.972516e-01 8.947433e-01 21 33594643 33594661 19 - 0.626 0.592 -0.151
ENSG00000205758 E020 32.8314838 0.0022211234 7.190672e-01 8.475970e-01 21 33594662 33595130 469 - 1.451 1.487 0.123
ENSG00000205758 E021 18.1935149 0.0025863091 9.101101e-01 9.572111e-01 21 33595131 33595336 206 - 1.215 1.237 0.076
ENSG00000205758 E022 10.6423732 0.0035107630 4.272582e-01 6.489309e-01 21 33595337 33595355 19 - 0.982 1.080 0.360
ENSG00000205758 E023 22.6576226 0.0440359601 8.156117e-01 9.056291e-01 21 33595356 33595528 173 - 1.295 1.353 0.202
ENSG00000205758 E024 14.4385982 0.1548484292 7.298810e-01 8.541600e-01 21 33595529 33595614 86 - 1.071 1.259 0.673
ENSG00000205758 E025 77.2104683 0.0005300374 8.618448e-02 2.567738e-01 21 33595731 33595836 106 - 1.842 1.771 -0.238
ENSG00000205758 E026 1.9169177 0.0109894420 5.393797e-01 7.285551e-01 21 33596003 33596061 59 - 0.446 0.335 -0.624
ENSG00000205758 E027 3.9115483 0.0798125414 7.240532e-01 8.506031e-01 21 33596062 33596213 152 - 0.646 0.592 -0.237
ENSG00000205758 E028 73.4222443 0.0006736808 3.650962e-01 6.000187e-01 21 33597280 33597401 122 - 1.813 1.780 -0.111
ENSG00000205758 E029 53.3232085 0.0008472602 7.494259e-02 2.346981e-01 21 33599150 33599195 46 - 1.692 1.601 -0.311
ENSG00000205758 E030 59.6640532 0.0006703017 1.372063e-01 3.432688e-01 21 33599196 33599248 53 - 1.734 1.665 -0.234
ENSG00000205758 E031 12.8332553 0.0532898101 2.270516e-01 4.618192e-01 21 33599249 33599285 37 - 1.110 0.936 -0.639
ENSG00000205758 E032 53.7407398 0.0129712032 3.503357e-01 5.875417e-01 21 33602234 33602266 33 - 1.689 1.631 -0.194
ENSG00000205758 E033 57.5264162 0.0144301390 3.614968e-01 5.969188e-01 21 33602267 33602331 65 - 1.718 1.664 -0.185
ENSG00000205758 E034 31.6198082 0.0014164167 4.704962e-01 6.804203e-01 21 33602332 33602332 1 - 1.464 1.423 -0.141
ENSG00000205758 E035 34.7353591 0.0015058222 7.497459e-01 8.666219e-01 21 33602333 33602345 13 - 1.495 1.485 -0.035
ENSG00000205758 E036 0.6072928 0.0195958696 2.674526e-01   21 33603156 33603403 248 - 0.133 0.335 1.696
ENSG00000205758 E037 81.5836935 0.0007552809 6.047968e-01 7.733625e-01 21 33603404 33603537 134 - 1.857 1.845 -0.041
ENSG00000205758 E038 73.1434728 0.0005659467 3.673737e-01 6.018746e-01 21 33613538 33613606 69 - 1.812 1.780 -0.108
ENSG00000205758 E039 18.6290324 0.0266518304 7.207566e-08 2.769881e-06 21 33616287 33616603 317 - 1.004 1.600 2.093
ENSG00000205758 E040 70.6439523 0.0005460737 1.118738e-02 6.314115e-02 21 33616706 33616750 45 - 1.757 1.883 0.428
ENSG00000205758 E041 2.1554107 0.0114080007 5.018148e-03 3.472119e-02 21 33616751 33617176 426 - 0.278 0.752 2.373
ENSG00000205758 E042 83.8515155 0.0004987804 7.981491e-03 4.921895e-02 21 33621996 33622068 73 - 1.828 1.951 0.412
ENSG00000205758 E043 70.2627440 0.0007727722 4.328393e-02 1.633069e-01 21 33624683 33624760 78 - 1.758 1.863 0.355
ENSG00000205758 E044 31.8014589 0.0127865398 1.418332e-01 3.502021e-01 21 33631486 33631492 7 - 1.414 1.546 0.452
ENSG00000205758 E045 41.0451417 0.0219849622 1.716537e-01 3.927349e-01 21 33631493 33631527 35 - 1.521 1.653 0.447
ENSG00000205758 E046 37.6978857 0.0306082391 3.584237e-01 5.945292e-01 21 33631528 33631557 30 - 1.492 1.592 0.341
ENSG00000205758 E047 0.2735028 0.0262235620 3.988866e-01   21 33633646 33633702 57 - 0.072 0.199 1.692
ENSG00000205758 E048 0.5470056 0.2775567817 3.490348e-01   21 33639745 33640188 444 - 0.131 0.327 1.673
ENSG00000205758 E049 0.7555370 0.0173705499 8.517437e-01   21 33641179 33641305 127 - 0.235 0.199 -0.304
ENSG00000205758 E050 29.9008502 0.0029811019 2.286041e-01 4.636154e-01 21 33641681 33642338 658 - 1.396 1.494 0.339
ENSG00000205758 E051 0.0000000       21 33643372 33643926 555 -