ENSG00000205593

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000413817 ENSG00000205593 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND6B protein_coding protein_coding 1.623182 2.176848 0.9333335 0.4203143 0.1219327 -1.213013 0.48289413 0.74773302 0.2687589 0.12527259 0.02771463 -1.4426716 0.29210833 0.34710000 0.30760000 -0.03950000 0.91985902 0.02430305 FALSE TRUE
ENST00000460087 ENSG00000205593 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND6B protein_coding retained_intron 1.623182 2.176848 0.9333335 0.4203143 0.1219327 -1.213013 0.08784285 0.03179501 0.1556784 0.03179501 0.04901197 1.9869829 0.05944167 0.01070000 0.16463333 0.15393333 0.02430305 0.02430305 FALSE FALSE
ENST00000471942 ENSG00000205593 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND6B protein_coding retained_intron 1.623182 2.176848 0.9333335 0.4203143 0.1219327 -1.213013 0.10531301 0.35770766 0.0679049 0.04717794 0.06790490 -2.2387732 0.07035833 0.17886667 0.06686667 -0.11200000 0.59248478 0.02430305 FALSE FALSE
ENST00000495607 ENSG00000205593 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND6B protein_coding retained_intron 1.623182 2.176848 0.9333335 0.4203143 0.1219327 -1.213013 0.39276338 0.69233981 0.2033379 0.02588975 0.03596075 -1.7190291 0.24022083 0.33920000 0.21923333 -0.11996667 0.73094456 0.02430305 FALSE TRUE
MSTRG.22372.2 ENSG00000205593 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND6B protein_coding   1.623182 2.176848 0.9333335 0.4203143 0.1219327 -1.213013 0.47030356 0.28037719 0.1806885 0.28037719 0.04830825 -0.6067105 0.29018750 0.09426667 0.18943333 0.09516667 0.57982101 0.02430305 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000205593 E001 38.8416714 0.005667425 0.693378140 0.83127192 22 50309030 50311965 2936 - 1.496 1.533 0.125
ENSG00000205593 E002 17.5222924 0.002578970 0.008345913 0.05090794 22 50311966 50312261 296 - 0.963 1.241 1.005
ENSG00000205593 E003 11.7835655 0.002877201 0.760161935 0.87262777 22 50312343 50312417 75 - 1.015 1.047 0.120
ENSG00000205593 E004 12.1385898 0.022755986 0.043176820 0.16301143 22 50312523 50312625 103 - 0.835 1.107 1.017
ENSG00000205593 E005 9.0215048 0.115119204 0.472580290 0.68192711 22 50312999 50313108 110 - 0.863 0.966 0.389
ENSG00000205593 E006 5.4724789 0.054922408 0.647852888 0.80210785 22 50313446 50313499 54 - 0.705 0.764 0.237
ENSG00000205593 E007 7.1830663 0.004963856 0.540408822 0.72928415 22 50313635 50313724 90 - 0.904 0.826 -0.298
ENSG00000205593 E008 9.6110993 0.014610960 0.892397667 0.94780267 22 50313814 50313878 65 - 0.963 0.956 -0.028
ENSG00000205593 E009 8.7628477 0.034572036 0.632595966 0.79204737 22 50313879 50314202 324 - 0.965 0.909 -0.212
ENSG00000205593 E010 3.4105071 0.007851384 0.584121266 0.75975108 22 50314203 50314206 4 - 0.654 0.565 -0.393
ENSG00000205593 E011 11.0572018 0.013000389 0.059098181 0.20074468 22 50314207 50314272 66 - 1.160 0.956 -0.745
ENSG00000205593 E012 8.5351072 0.018070127 0.074299443 0.23335968 22 50314400 50314494 95 - 1.062 0.841 -0.828
ENSG00000205593 E013 11.5869310 0.008191760 0.735000745 0.85723652 22 50314605 50314700 96 - 1.061 1.027 -0.125
ENSG00000205593 E014 6.3071271 0.004776034 0.097719963 0.27777476 22 50314799 50314821 23 - 0.593 0.849 1.053
ENSG00000205593 E015 8.6219307 0.008898637 0.356135573 0.59263335 22 50314822 50314921 100 - 0.835 0.954 0.455
ENSG00000205593 E016 8.6260537 0.065806901 0.405524975 0.63271136 22 50315714 50315769 56 - 0.832 0.948 0.443
ENSG00000205593 E017 7.7481589 0.091795527 0.772286681 0.88000242 22 50316025 50316087 63 - 0.868 0.880 0.046
ENSG00000205593 E018 1.2078608 0.143767375 0.821247339   22 50316088 50316173 86 - 0.334 0.282 -0.339
ENSG00000205593 E019 9.7719726 0.004085192 0.615168341 0.78037526 22 50316174 50316253 80 - 1.014 0.955 -0.219
ENSG00000205593 E020 2.8681808 0.126348551 0.890526043 0.94695656 22 50316254 50316369 116 - 0.521 0.529 0.036
ENSG00000205593 E021 10.8076467 0.009806327 0.393347993 0.62303534 22 50316370 50316475 106 - 1.081 0.981 -0.367
ENSG00000205593 E022 3.2233661 0.263441410 0.866032106 0.93375006 22 50316566 50316626 61 - 0.693 0.539 -0.675
ENSG00000205593 E023 1.5100058 0.074293598 0.663822586 0.81230760 22 50316627 50316653 27 - 0.438 0.350 -0.490
ENSG00000205593 E024 1.9864305 0.035602306 0.251234602 0.48930858 22 50316654 50316712 59 - 0.592 0.384 -1.033
ENSG00000205593 E025 1.7011612 0.012266340 0.760407604 0.87277559 22 50316713 50316864 152 - 0.440 0.384 -0.299
ENSG00000205593 E026 7.1192761 0.034515765 0.347949061 0.58538322 22 50317293 50317373 81 - 0.933 0.816 -0.448
ENSG00000205593 E027 10.2914420 0.004238925 0.488639684 0.69308705 22 50317908 50318020 113 - 1.039 0.964 -0.277
ENSG00000205593 E028 7.8603747 0.019613076 0.514656097 0.71145769 22 50318847 50318889 43 - 0.935 0.851 -0.322
ENSG00000205593 E029 0.6544085 0.019545249 0.030684193   22 50318890 50318964 75 - 0.440 0.071 -3.298
ENSG00000205593 E030 7.7998272 0.004687570 0.737342517 0.85883482 22 50318965 50319003 39 - 0.835 0.881 0.176
ENSG00000205593 E031 0.7962354 0.017267182 0.407965333   22 50319004 50319095 92 - 0.336 0.186 -1.129
ENSG00000205593 E032 7.4928854 0.061899730 0.634470697 0.79323083 22 50326812 50327012 201 - 0.798 0.874 0.298