ENSG00000205531

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380542 ENSG00000205531 HEK293_OSMI2_6hA HEK293_TMG_6hB NAP1L4 protein_coding protein_coding 92.50107 61.74766 119.2179 5.259501 6.21689 0.9490323 13.93549 6.377916 18.65248 2.0234156 1.876709 1.5467236 0.1446625 0.0989000 0.1558667 0.05696667 5.950433e-01 7.134607e-16 FALSE TRUE
ENST00000620138 ENSG00000205531 HEK293_OSMI2_6hA HEK293_TMG_6hB NAP1L4 protein_coding protein_coding 92.50107 61.74766 119.2179 5.259501 6.21689 0.9490323 50.64846 39.565980 55.18930 4.9676428 1.789503 0.4800249 0.5687292 0.6359333 0.4645000 -0.17143333 2.852812e-02 7.134607e-16 FALSE TRUE
MSTRG.4977.8 ENSG00000205531 HEK293_OSMI2_6hA HEK293_TMG_6hB NAP1L4 protein_coding   92.50107 61.74766 119.2179 5.259501 6.21689 0.9490323 11.03192 2.554560 22.81418 0.5545859 1.387029 3.1537801 0.1011292 0.0404000 0.1922000 0.15180000 2.275252e-09 7.134607e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000205531 E001 1.976569 0.0404993382 0.242896852 0.47984589 11 2944431 2944436 6 - 0.345 0.603 1.310
ENSG00000205531 E002 3.160897 0.0458691723 0.009232144 0.05484222 11 2944437 2944437 1 - 0.345 0.848 2.316
ENSG00000205531 E003 825.592860 1.7525419202 0.365462234 0.60031091 11 2944438 2945062 625 - 2.699 3.116 1.385
ENSG00000205531 E004 217.663921 1.3443022218 0.370008475 0.60395953 11 2945063 2945111 49 - 2.165 2.508 1.144
ENSG00000205531 E005 500.104351 1.6147264821 0.390951438 0.62111801 11 2945112 2945330 219 - 2.514 2.876 1.206
ENSG00000205531 E006 356.069886 1.5021549708 0.375628223 0.60870941 11 2945331 2945434 104 - 2.366 2.730 1.212
ENSG00000205531 E007 373.051852 1.5113178840 0.366149471 0.60089169 11 2945435 2945596 162 - 2.377 2.757 1.267
ENSG00000205531 E008 253.632068 1.4076360859 0.400541037 0.62874658 11 2945597 2945646 50 - 2.245 2.563 1.059
ENSG00000205531 E009 56.327009 0.6649863797 0.320164302 0.55988339 11 2949227 2949264 38 - 1.632 1.885 0.856
ENSG00000205531 E010 15.523078 0.2760022949 0.067446496 0.21934126 11 2950969 2951016 48 - 0.946 1.451 1.801
ENSG00000205531 E011 361.003104 1.5809867007 0.474679897 0.68334922 11 2951259 2951315 57 - 2.429 2.688 0.864
ENSG00000205531 E012 324.113163 1.5366734073 0.519531843 0.71473033 11 2951780 2951809 30 - 2.410 2.613 0.676
ENSG00000205531 E013 23.069218 0.3755045151 0.099998295 0.28178426 11 2951810 2951897 88 - 1.112 1.613 1.743
ENSG00000205531 E014 83.833890 0.8413614528 0.262872700 0.50210134 11 2951898 2952769 872 - 1.686 2.143 1.537
ENSG00000205531 E015 12.073545 0.4611828971 0.737233693 0.85872889 11 2954301 2954303 3 - 1.055 1.175 0.432
ENSG00000205531 E016 25.167476 0.6521068063 0.591056908 0.76443036 11 2954304 2954410 107 - 1.320 1.517 0.679
ENSG00000205531 E017 17.431082 0.6752222876 0.754343726 0.86930402 11 2954411 2954487 77 - 1.178 1.354 0.617
ENSG00000205531 E018 15.848692 0.5994887284 0.662405337 0.81137933 11 2954488 2954526 39 - 1.123 1.333 0.741
ENSG00000205531 E019 378.960720 1.5819232283 0.510407367 0.70828468 11 2954527 2954561 35 - 2.470 2.689 0.729
ENSG00000205531 E020 486.103525 1.6655858173 0.528448560 0.72094087 11 2954562 2954646 85 - 2.582 2.793 0.702
ENSG00000205531 E021 369.649040 0.0441546713 0.399508382 0.62788218 11 2955744 2955766 23 - 2.503 2.629 0.420
ENSG00000205531 E022 5.297692 0.1012764376 0.925942047 0.96508581 11 2955767 2955790 24 - 0.780 0.794 0.056
ENSG00000205531 E023 587.004213 0.0001575057 0.008600055 0.05204783 11 2958399 2958483 85 - 2.740 2.785 0.148
ENSG00000205531 E024 379.924804 0.0062661184 0.011325280 0.06370629 11 2958484 2958490 7 - 2.569 2.561 -0.027
ENSG00000205531 E025 577.878352 0.0084602327 0.005463817 0.03703823 11 2958491 2958544 54 - 2.757 2.730 -0.091
ENSG00000205531 E026 4.097570 0.2363339532 0.753858929 0.86904622 11 2958545 2958934 390 - 0.593 0.824 0.956
ENSG00000205531 E027 752.483473 0.0166995731 0.018648600 0.09122746 11 2959770 2959909 140 - 2.877 2.835 -0.139
ENSG00000205531 E028 4.890223 0.1611259248 0.374776999 0.60796816 11 2959910 2960131 222 - 0.627 0.901 1.108
ENSG00000205531 E029 404.655446 0.0106070300 0.006534594 0.04238825 11 2964680 2964718 39 - 2.608 2.565 -0.143
ENSG00000205531 E030 281.887759 0.0154687511 0.014263852 0.07539623 11 2964719 2964724 6 - 2.456 2.400 -0.186
ENSG00000205531 E031 320.668211 0.0122030805 0.004276790 0.03070505 11 2964725 2964751 27 - 2.514 2.452 -0.207
ENSG00000205531 E032 379.330091 0.0078352781 0.006169486 0.04056059 11 2969803 2969864 62 - 2.575 2.548 -0.090
ENSG00000205531 E033 380.958512 0.0146712962 0.024811090 0.11164531 11 2969865 2969915 51 - 2.579 2.545 -0.115
ENSG00000205531 E034 296.550360 0.0140489453 0.002612226 0.02104241 11 2969916 2969934 19 - 2.487 2.404 -0.278
ENSG00000205531 E035 284.500545 0.0174396409 0.006672210 0.04306053 11 2971448 2971449 2 - 2.469 2.387 -0.274
ENSG00000205531 E036 317.435171 0.0186092839 0.008759487 0.05275231 11 2971450 2971463 14 - 2.515 2.436 -0.264
ENSG00000205531 E037 468.900532 0.0202671873 0.013419456 0.07209288 11 2971464 2971528 65 - 2.681 2.611 -0.236
ENSG00000205531 E038 295.007561 0.0274670303 0.024537345 0.11080104 11 2971529 2971534 6 - 2.485 2.400 -0.285
ENSG00000205531 E039 394.099056 0.0251747418 0.024116350 0.10941787 11 2972102 2972148 47 - 2.608 2.532 -0.252
ENSG00000205531 E040 301.635279 0.0229978179 0.035258075 0.14226121 11 2972149 2972180 32 - 2.486 2.427 -0.198
ENSG00000205531 E041 248.762519 0.0241965470 0.098849259 0.27977663 11 2972181 2972194 14 - 2.392 2.364 -0.092
ENSG00000205531 E042 408.858915 0.0205035910 0.048529169 0.17624827 11 2972195 2972243 49 - 2.610 2.573 -0.123
ENSG00000205531 E043 10.321859 0.0345106480 0.304200013 0.54478322 11 2972244 2972279 36 - 0.946 1.164 0.797
ENSG00000205531 E044 473.868814 0.0245054837 0.125542686 0.32471839 11 2976024 2976123 100 - 2.665 2.654 -0.037
ENSG00000205531 E045 334.416069 0.0208884718 0.067943333 0.22046376 11 2978284 2978342 59 - 2.520 2.493 -0.089
ENSG00000205531 E046 241.356905 0.0215698035 0.209804024 0.44163205 11 2979207 2979237 31 - 2.365 2.377 0.038
ENSG00000205531 E047 1.726172 0.0106744581 0.375814488 0.60885439 11 2981702 2981799 98 - 0.346 0.551 1.071
ENSG00000205531 E048 2.427436 0.0909525055 0.225633739 0.46009148 11 2983746 2983813 68 - 0.390 0.688 1.411
ENSG00000205531 E049 3.216851 0.1221300682 0.665705078 0.81345803 11 2988077 2988126 50 - 0.624 0.596 -0.123
ENSG00000205531 E050 40.474700 0.0304991659 0.499278757 0.70032579 11 2989129 2989197 69 - 1.590 1.627 0.128
ENSG00000205531 E051 5.424302 0.0057377533 0.616559296 0.78141830 11 2989198 2989271 74 - 0.731 0.870 0.547
ENSG00000205531 E052 1.286452 0.0138557758 0.606525752   11 2990909 2990992 84 - 0.295 0.433 0.812
ENSG00000205531 E053 14.190410 0.0308655040 0.009295324 0.05507308 11 2991794 2992228 435 - 0.969 1.370 1.434
ENSG00000205531 E054 5.885344 0.0058109447 0.284864027 0.52543134 11 2992229 2992253 25 - 0.750 0.959 0.808
ENSG00000205531 E055 152.802038 0.0341229537 0.217452338 0.45034644 11 2992254 2992377 124 - 2.174 2.169 -0.017