ENSG00000205356

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000447648 ENSG00000205356 HEK293_OSMI2_6hA HEK293_TMG_6hB TECPR1 protein_coding protein_coding 7.752023 11.98612 7.464957 1.160298 0.6160556 -0.6824312 3.8876602 6.2034253 2.135170 0.8016398 0.04908165 -1.5342968 0.48939167 0.51660000 0.2894333 -0.22716667 0.01764880 0.0176488 FALSE TRUE
ENST00000463648 ENSG00000205356 HEK293_OSMI2_6hA HEK293_TMG_6hB TECPR1 protein_coding retained_intron 7.752023 11.98612 7.464957 1.160298 0.6160556 -0.6824312 0.6894592 0.3679969 2.585404 0.3679969 0.47844929 2.7795128 0.09392083 0.03366667 0.3402000 0.30653333 0.08338087 0.0176488 FALSE FALSE
ENST00000474915 ENSG00000205356 HEK293_OSMI2_6hA HEK293_TMG_6hB TECPR1 protein_coding retained_intron 7.752023 11.98612 7.464957 1.160298 0.6160556 -0.6824312 0.1553582 0.6744707 0.000000 0.3410798 0.00000000 -6.0969169 0.01590417 0.05506667 0.0000000 -0.05506667 0.32290128 0.0176488 FALSE FALSE
MSTRG.30283.3 ENSG00000205356 HEK293_OSMI2_6hA HEK293_TMG_6hB TECPR1 protein_coding   7.752023 11.98612 7.464957 1.160298 0.6160556 -0.6824312 1.6701166 2.8663805 1.577228 0.5228935 0.12838833 -0.8577455 0.22306250 0.23873333 0.2174000 -0.02133333 0.95896648 0.0176488 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000205356 E001 11.0949889 0.0199084619 1.889958e-01 4.157007e-01 7 98214624 98215515 892 - 0.889 1.066 0.658
ENSG00000205356 E002 54.2259592 0.0062851767 3.585778e-01 5.946223e-01 7 98215516 98215729 214 - 1.635 1.700 0.218
ENSG00000205356 E003 31.2350323 0.0015954951 2.677329e-01 5.073805e-01 7 98215730 98215730 1 - 1.391 1.474 0.288
ENSG00000205356 E004 219.1355722 0.0002580632 9.297905e-03 5.507890e-02 7 98215731 98216736 1006 - 2.225 2.297 0.241
ENSG00000205356 E005 15.1056327 0.0024826300 6.320510e-02 2.099227e-01 7 98216737 98216759 23 - 0.999 1.198 0.719
ENSG00000205356 E006 25.1848719 0.0016197109 3.356956e-01 5.741766e-01 7 98216760 98216812 53 - 1.303 1.382 0.275
ENSG00000205356 E007 143.6409880 0.0003443116 9.455645e-01 9.751125e-01 7 98216813 98217503 691 - 2.097 2.101 0.011
ENSG00000205356 E008 42.4571394 0.0025894004 4.450459e-01 6.621665e-01 7 98217692 98217742 51 - 1.540 1.591 0.175
ENSG00000205356 E009 47.3490893 0.0008517443 7.851689e-02 2.418247e-01 7 98217743 98217811 69 - 1.540 1.648 0.368
ENSG00000205356 E010 3.6085707 0.2164547652 5.538385e-01 7.389750e-01 7 98217812 98217838 27 - 0.697 0.579 -0.513
ENSG00000205356 E011 39.5456907 0.0009910620 6.052408e-01 7.737006e-01 7 98217936 98217966 31 - 1.574 1.542 -0.108
ENSG00000205356 E012 47.0264808 0.0008375303 7.079079e-01 8.404987e-01 7 98217967 98218042 76 - 1.605 1.628 0.077
ENSG00000205356 E013 57.2794292 0.0008572805 3.907819e-01 6.209940e-01 7 98221661 98221753 93 - 1.672 1.720 0.159
ENSG00000205356 E014 0.5059767 0.0217415224 4.348471e-01   7 98222385 98222385 1 - 0.000 0.192 11.085
ENSG00000205356 E015 65.3747871 0.0019798928 1.234313e-01 3.211836e-01 7 98222386 98222521 136 - 1.698 1.780 0.279
ENSG00000205356 E016 0.5481031 0.4138691616 7.654751e-01   7 98222522 98222876 355 - 0.192 0.143 -0.508
ENSG00000205356 E017 0.0000000       7 98222877 98222974 98 -      
ENSG00000205356 E018 31.7255286 0.0025349107 3.333861e-01 5.719660e-01 7 98222990 98223030 41 - 1.401 1.472 0.247
ENSG00000205356 E019 56.9734627 0.0008702797 9.966836e-01 1.000000e+00 7 98223031 98223170 140 - 1.698 1.698 0.001
ENSG00000205356 E020 40.5546458 0.0009618561 9.745187e-02 2.773097e-01 7 98223662 98223718 57 - 1.629 1.529 -0.343
ENSG00000205356 E021 1.8083765 0.0721267949 8.716187e-01 9.368378e-01 7 98223719 98223743 25 - 0.429 0.396 -0.180
ENSG00000205356 E022 52.9931436 0.0007797200 8.138834e-01 9.045972e-01 7 98224801 98224880 80 - 1.662 1.676 0.048
ENSG00000205356 E023 59.3281680 0.0007757406 5.690079e-01 7.495231e-01 7 98225006 98225102 97 - 1.744 1.716 -0.095
ENSG00000205356 E024 1.7852760 0.0109843470 1.892260e-01 4.160023e-01 7 98226592 98226769 178 - 0.194 0.455 1.720
ENSG00000205356 E025 60.0867790 0.0013242106 6.700869e-01 8.163489e-01 7 98228014 98228116 103 - 1.707 1.731 0.081
ENSG00000205356 E026 1.0177506 0.0172671820 6.452487e-01   7 98228508 98228684 177 - 0.327 0.241 -0.600
ENSG00000205356 E027 0.1723744 0.0362664708 1.000000e+00   7 98228774 98229038 265 - 0.000 0.074 9.404
ENSG00000205356 E028 23.7230527 0.0258114822 9.715009e-02 2.767710e-01 7 98229039 98229043 5 - 1.176 1.375 0.698
ENSG00000205356 E029 57.5166653 0.0008927645 7.543565e-02 2.357333e-01 7 98229044 98229166 123 - 1.629 1.729 0.338
ENSG00000205356 E030 58.0825978 0.0006816815 4.269483e-01 6.486887e-01 7 98230961 98231118 158 - 1.678 1.721 0.147
ENSG00000205356 E031 57.2539147 0.0007064808 4.567163e-01 6.708104e-01 7 98231224 98231373 150 - 1.673 1.714 0.139
ENSG00000205356 E032 0.7608862 0.1322046735 5.163445e-01   7 98231374 98231626 253 - 0.325 0.192 -1.005
ENSG00000205356 E033 59.2827096 0.0010608609 6.744789e-02 2.193413e-01 7 98231804 98231959 156 - 1.790 1.697 -0.313
ENSG00000205356 E034 58.4912474 0.0019836511 2.815424e-01 5.218575e-01 7 98232827 98232972 146 - 1.761 1.703 -0.196
ENSG00000205356 E035 13.1570755 0.0987939587 4.362228e-01 6.559759e-01 7 98232973 98233420 448 - 1.189 1.056 -0.478
ENSG00000205356 E036 22.7923024 0.0017360302 7.624151e-01 8.740376e-01 7 98233421 98233426 6 - 1.303 1.329 0.091
ENSG00000205356 E037 112.8373279 0.0004083156 9.625934e-01 9.832398e-01 7 98233427 98233911 485 - 1.992 1.994 0.008
ENSG00000205356 E038 52.8567831 0.0009754244 5.261265e-01 7.193122e-01 7 98236776 98236862 87 - 1.693 1.658 -0.120
ENSG00000205356 E039 47.1919811 0.0008447521 6.789201e-01 8.220526e-01 7 98236863 98236921 59 - 1.640 1.617 -0.081
ENSG00000205356 E040 0.0000000       7 98238504 98238508 5 -      
ENSG00000205356 E041 70.3816165 0.0006218416 7.412403e-03 4.662036e-02 7 98238509 98238610 102 - 1.882 1.759 -0.415
ENSG00000205356 E042 67.3134943 0.0012939147 1.518953e-07 5.394253e-06 7 98240851 98240951 101 - 1.945 1.698 -0.835
ENSG00000205356 E043 76.8666073 0.0007237632 2.201053e-02 1.026189e-01 7 98241070 98241244 175 - 1.904 1.802 -0.345
ENSG00000205356 E044 53.2471308 0.0008204997 5.112469e-01 7.089256e-01 7 98243467 98243570 104 - 1.698 1.663 -0.120
ENSG00000205356 E045 30.9178545 0.0067904046 3.847213e-01 6.162568e-01 7 98243571 98243592 22 - 1.391 1.464 0.250
ENSG00000205356 E046 51.8597791 0.0009816075 6.108617e-01 7.775208e-01 7 98244571 98244693 123 - 1.641 1.671 0.103
ENSG00000205356 E047 41.8694792 0.0008659450 4.064309e-01 6.333439e-01 7 98244885 98244989 105 - 1.612 1.563 -0.167
ENSG00000205356 E048 31.8018398 0.0038174829 5.777634e-01 7.556384e-01 7 98244990 98245034 45 - 1.488 1.451 -0.129
ENSG00000205356 E049 22.6757920 0.0016171214 9.869354e-01 9.953105e-01 7 98245035 98245042 8 - 1.315 1.318 0.010
ENSG00000205356 E050 25.8043090 0.0014653056 9.965589e-01 9.999741e-01 7 98245043 98245067 25 - 1.371 1.372 0.006
ENSG00000205356 E051 0.9388700 0.0254285457 1.959073e-01   7 98245068 98245106 39 - 0.429 0.192 -1.600
ENSG00000205356 E052 67.7864994 0.0005979137 1.701828e-01 3.906801e-01 7 98245922 98246165 244 - 1.824 1.759 -0.220
ENSG00000205356 E053 0.6182515 0.0322850880 1.000000e+00   7 98250914 98251393 480 - 0.193 0.192 -0.014
ENSG00000205356 E054 13.9948426 0.0027545131 7.017686e-01 8.366900e-01 7 98251394 98251418 25 - 1.088 1.127 0.143
ENSG00000205356 E055 47.1359674 0.0010880098 8.770949e-01 9.397675e-01 7 98251419 98251548 130 - 1.612 1.621 0.030
ENSG00000205356 E056 0.2617363 0.0717616914 7.610228e-01   7 98251790 98251900 111 - 0.000 0.136 10.153
ENSG00000205356 E057 0.4756169 0.0395191467 4.387145e-01   7 98251901 98252125 225 - 0.000 0.192 10.935
ENSG00000205356 E058 29.3442902 0.0013454259 7.519440e-01 8.679405e-01 7 98252126 98252232 107 - 1.401 1.424 0.081