ENSG00000204852

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000480648 ENSG00000204852 HEK293_OSMI2_6hA HEK293_TMG_6hB TCTN1 protein_coding nonsense_mediated_decay 21.37627 16.50684 15.11346 0.8268993 0.7624276 -0.1271499 1.2871659 0.7363375 0.5824039 0.05058693 0.2912130 -0.3332471 0.05992083 0.04466667 0.037633333 -0.007033333 8.943283e-01 1.810015e-06 FALSE TRUE
ENST00000546643 ENSG00000204852 HEK293_OSMI2_6hA HEK293_TMG_6hB TCTN1 protein_coding nonsense_mediated_decay 21.37627 16.50684 15.11346 0.8268993 0.7624276 -0.1271499 0.8154857 0.0000000 1.5644007 0.00000000 0.6498863 7.2986589 0.04018333 0.00000000 0.105866667 0.105866667 1.810015e-06 1.810015e-06 FALSE FALSE
ENST00000551590 ENSG00000204852 HEK293_OSMI2_6hA HEK293_TMG_6hB TCTN1 protein_coding protein_coding 21.37627 16.50684 15.11346 0.8268993 0.7624276 -0.1271499 0.9992714 0.3318744 0.3980165 0.33187444 0.3980165 0.2551611 0.05292083 0.01933333 0.027933333 0.008600000 1.000000e+00 1.810015e-06 FALSE TRUE
ENST00000552318 ENSG00000204852 HEK293_OSMI2_6hA HEK293_TMG_6hB TCTN1 protein_coding nonsense_mediated_decay 21.37627 16.50684 15.11346 0.8268993 0.7624276 -0.1271499 0.7939940 1.0098675 0.1260879 0.08665088 0.1260879 -2.9057705 0.03267083 0.06106667 0.008833333 -0.052233333 1.640839e-01 1.810015e-06 TRUE TRUE
ENST00000614115 ENSG00000204852 HEK293_OSMI2_6hA HEK293_TMG_6hB TCTN1 protein_coding protein_coding 21.37627 16.50684 15.11346 0.8268993 0.7624276 -0.1271499 2.4366997 1.6781581 1.4343015 0.27024106 0.3935498 -0.2250781 0.11414167 0.10310000 0.093800000 -0.009300000 9.631854e-01 1.810015e-06 FALSE TRUE
MSTRG.8017.38 ENSG00000204852 HEK293_OSMI2_6hA HEK293_TMG_6hB TCTN1 protein_coding   21.37627 16.50684 15.11346 0.8268993 0.7624276 -0.1271499 5.3160895 4.3022265 3.4657096 0.40862444 0.3986353 -0.3111254 0.24384167 0.26226667 0.227900000 -0.034366667 8.556322e-01 1.810015e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000204852 E001 0.7087110 0.0193874923 0.0807378188   12 110614027 110614062 36 + 0.000 0.314 12.380
ENSG00000204852 E002 4.3747477 0.0056683732 0.4235464487 0.6462743712 12 110614063 110614101 39 + 0.656 0.761 0.434
ENSG00000204852 E003 4.9525905 0.0052694843 0.2222458290 0.4561681388 12 110614102 110614105 4 + 0.656 0.818 0.657
ENSG00000204852 E004 5.1249649 0.0050545114 0.1763511569 0.3989031390 12 110614106 110614106 1 + 0.656 0.835 0.725
ENSG00000204852 E005 5.7815863 0.0049945111 0.4279536059 0.6494526298 12 110614107 110614111 5 + 0.757 0.852 0.374
ENSG00000204852 E006 5.7815863 0.0049945111 0.4279536059 0.6494526298 12 110614112 110614112 1 + 0.757 0.852 0.374
ENSG00000204852 E007 7.4004727 0.0042325257 0.4705501856 0.6804520225 12 110614113 110614123 11 + 0.862 0.939 0.292
ENSG00000204852 E008 7.7340751 0.0041111602 0.3430993928 0.5807563080 12 110614124 110614125 2 + 0.862 0.965 0.388
ENSG00000204852 E009 7.7340751 0.0041111602 0.3430993928 0.5807563080 12 110614126 110614127 2 + 0.862 0.965 0.388
ENSG00000204852 E010 7.7340751 0.0041111602 0.3430993928 0.5807563080 12 110614128 110614128 1 + 0.862 0.965 0.388
ENSG00000204852 E011 7.7340751 0.0041111602 0.3430993928 0.5807563080 12 110614129 110614129 1 + 0.862 0.965 0.388
ENSG00000204852 E012 9.7148986 0.0034368434 0.4123675080 0.6378768438 12 110614130 110614136 7 + 0.966 1.044 0.289
ENSG00000204852 E013 9.8872729 0.0033168063 0.3581570602 0.5943316471 12 110614137 110614138 2 + 0.966 1.055 0.326
ENSG00000204852 E014 13.6588621 0.0043691797 0.4413675717 0.6596628163 12 110614139 110614147 9 + 1.107 1.171 0.228
ENSG00000204852 E015 14.1960065 0.0076704923 0.5649337228 0.7467444473 12 110614148 110614152 5 + 1.133 1.179 0.164
ENSG00000204852 E016 16.4087539 0.0024066169 0.3640963168 0.5991063361 12 110614153 110614163 11 + 1.180 1.248 0.241
ENSG00000204852 E017 21.5296185 0.0241221164 0.5826495972 0.7587983324 12 110614164 110614164 1 + 1.310 1.354 0.154
ENSG00000204852 E018 23.0668479 0.0138656084 0.6566291983 0.8077093711 12 110614165 110614167 3 + 1.349 1.378 0.101
ENSG00000204852 E019 30.1759602 0.0034798684 0.2724582864 0.5123088221 12 110614168 110614180 13 + 1.437 1.503 0.226
ENSG00000204852 E020 95.3445791 0.0055793028 0.7791323489 0.8842312306 12 110614181 110614402 222 + 1.971 1.975 0.013
ENSG00000204852 E021 3.5373814 0.0075328064 0.9959210317 0.9995822315 12 110614403 110614463 61 + 0.656 0.648 -0.036
ENSG00000204852 E022 0.1308682 0.0325507576 0.6738921423   12 110616277 110616352 76 + 0.000 0.102 10.384
ENSG00000204852 E023 0.0000000       12 110616721 110616747 27 +      
ENSG00000204852 E024 0.6072928 0.0196215363 0.7186332420   12 110616748 110616904 157 + 0.252 0.185 -0.567
ENSG00000204852 E025 74.7196946 0.0070383235 0.8928484420 0.9480607565 12 110619836 110619956 121 + 1.873 1.870 -0.013
ENSG00000204852 E026 0.1614157 0.0329023905 0.3447034580   12 110623531 110623583 53 + 0.144 0.000 -11.556
ENSG00000204852 E027 76.1025617 0.0036394215 0.1783544585 0.4017120811 12 110626362 110626434 73 + 1.923 1.846 -0.259
ENSG00000204852 E028 62.3325913 0.0064342796 0.4111650400 0.6369187360 12 110626435 110626492 58 + 1.827 1.767 -0.205
ENSG00000204852 E029 0.3040503 0.0274424043 0.1196100173   12 110626881 110627929 1049 + 0.252 0.000 -12.555
ENSG00000204852 E030 0.7695163 0.0558071313 0.0074526597   12 110627930 110628051 122 + 0.471 0.000 -13.874
ENSG00000204852 E031 1.7505127 0.0129827951 0.0066238497 0.0428200239 12 110628052 110628224 173 + 0.656 0.185 -2.733
ENSG00000204852 E032 45.0496738 0.0067512610 0.5613612741 0.7442699992 12 110628767 110628796 30 + 1.679 1.629 -0.168
ENSG00000204852 E033 85.9198912 0.0065486438 0.0569468566 0.1959156012 12 110628797 110628918 122 + 1.989 1.878 -0.374
ENSG00000204852 E034 75.3690915 0.0379746360 0.0000457436 0.0007709722 12 110628919 110630287 1369 + 2.078 1.659 -1.412
ENSG00000204852 E035 85.9266724 0.0019436952 0.1194311725 0.3149403727 12 110632472 110632559 88 + 1.970 1.892 -0.261
ENSG00000204852 E036 10.2497906 0.1861467051 0.0262212376 0.1159989899 12 110632560 110633449 890 + 1.234 0.843 -1.435
ENSG00000204852 E037 1.1888398 0.0659865021 0.3936709279   12 110634311 110634395 85 + 0.252 0.410 0.999
ENSG00000204852 E038 5.8812867 0.0048251785 0.1086818218 0.2969018415 12 110634396 110634463 68 + 0.693 0.897 0.812
ENSG00000204852 E039 1.7301161 0.0306131128 0.7838177383 0.8868617253 12 110634464 110634669 206 + 0.471 0.413 -0.299
ENSG00000204852 E040 72.3905729 0.0008074952 0.1836996677 0.4087314333 12 110634670 110634779 110 + 1.892 1.823 -0.230
ENSG00000204852 E041 4.5099507 0.1449708711 0.2521984091 0.4902597348 12 110635667 110635950 284 + 0.839 0.649 -0.769
ENSG00000204852 E042 7.2932343 0.2126511097 0.1273080218 0.3275871024 12 110635951 110636244 294 + 1.035 0.796 -0.907
ENSG00000204852 E043 3.3235120 0.1055982300 0.2763311458 0.5163323743 12 110636245 110636369 125 + 0.727 0.534 -0.841
ENSG00000204852 E044 2.1120669 0.0330735458 0.3657494708 0.6005518185 12 110636370 110636480 111 + 0.575 0.413 -0.795
ENSG00000204852 E045 42.8929271 0.0008871867 0.7701626173 0.8787322071 12 110636481 110636501 21 + 1.626 1.630 0.015
ENSG00000204852 E046 93.6166495 0.0004656271 0.8687836072 0.9352619208 12 110640383 110640517 135 + 1.972 1.954 -0.060
ENSG00000204852 E047 71.5997564 0.0006040124 0.7952298676 0.8935009742 12 110641024 110641149 126 + 1.858 1.835 -0.076
ENSG00000204852 E048 58.0055487 0.0038194219 0.9163203062 0.9603724038 12 110641542 110641627 86 + 1.754 1.752 -0.007
ENSG00000204852 E049 1.9621575 0.0824657859 0.7268782894 0.8523456852 12 110641628 110641629 2 + 0.410 0.497 0.448
ENSG00000204852 E050 19.5983210 0.1232718244 0.9664473718 0.9851085316 12 110641630 110642248 619 + 1.262 1.332 0.245
ENSG00000204852 E051 66.6859155 0.0006641510 0.5617516201 0.7445143432 12 110642249 110642389 141 + 1.805 1.820 0.049
ENSG00000204852 E052 41.4236305 0.0460732916 0.9411180163 0.9727954623 12 110643356 110644655 1300 + 1.610 1.621 0.037
ENSG00000204852 E053 5.4697290 0.0119056594 0.8788024524 0.9406834459 12 110644656 110644707 52 + 0.786 0.800 0.057
ENSG00000204852 E054 7.0582401 0.0040535874 0.1564532717 0.3715352407 12 110644708 110644879 172 + 0.786 0.952 0.640
ENSG00000204852 E055 5.0954422 0.0143287777 0.0066349650 0.0428806366 12 110644880 110644966 87 + 0.471 0.885 1.768
ENSG00000204852 E056 30.4064183 0.0012737048 0.2926126525 0.5333089025 12 110644967 110644972 6 + 1.449 1.506 0.196
ENSG00000204852 E057 39.5462531 0.0009582669 0.3845839093 0.6161469097 12 110644973 110644991 19 + 1.570 1.608 0.130
ENSG00000204852 E058 85.6168208 0.0004591242 0.1960181280 0.4245666083 12 110644992 110645129 138 + 1.900 1.939 0.131
ENSG00000204852 E059 7.1296240 0.0390144496 0.7333573186 0.8562692677 12 110645130 110645143 14 + 0.861 0.917 0.215
ENSG00000204852 E060 26.5593697 0.0717663852 0.2014429023 0.4314985683 12 110645144 110646427 1284 + 1.274 1.509 0.815
ENSG00000204852 E061 8.6339999 0.0337012564 0.1077023965 0.2952198221 12 110646428 110646734 307 + 0.814 1.048 0.882
ENSG00000204852 E062 16.0158023 0.0434089913 0.1227594751 0.3201084412 12 110646735 110647195 461 + 1.065 1.294 0.817
ENSG00000204852 E063 7.6166524 0.0038193653 0.7201052396 0.8482598348 12 110647196 110647210 15 + 0.907 0.939 0.121
ENSG00000204852 E064 78.8274108 0.0005597711 0.1618367874 0.3794873004 12 110647211 110647292 82 + 1.858 1.904 0.155
ENSG00000204852 E065 42.9199644 0.0015909116 0.9658842963 0.9848355417 12 110647293 110647300 8 + 1.633 1.625 -0.028
ENSG00000204852 E066 46.1711495 0.0011941094 0.6265895431 0.7882580280 12 110647301 110647336 36 + 1.649 1.664 0.052
ENSG00000204852 E067 8.2744591 0.1094041616 0.2315872209 0.4669554400 12 110647337 110647748 412 + 0.760 1.045 1.088
ENSG00000204852 E068 61.3932855 0.0199322704 0.1152460543 0.3078672771 12 110647749 110647893 145 + 1.711 1.829 0.398
ENSG00000204852 E069 29.5179963 0.4444142914 0.2658529203 0.5052648480 12 110649043 110649100 58 + 1.324 1.553 0.791
ENSG00000204852 E070 4.0983664 0.0717179710 0.7268541556 0.8523328864 12 110649101 110649430 330 + 0.754 0.672 -0.338
ENSG00000204852 E071 4.1821010 0.0480664262 0.6285325829 0.7896273276 12 110663058 110663431 374 + 0.655 0.725 0.291