ENSG00000204839

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398882 ENSG00000204839 HEK293_OSMI2_6hA HEK293_TMG_6hB MROH6 protein_coding protein_coding 4.510044 3.475657 4.40047 0.1190559 0.3050391 0.3395019 0.3621599 0.49952255 0.56004209 0.13141240 0.07553220 0.1619225 0.08637917 0.14313333 0.129566667 -0.01356667 0.96422385 0.02159684 FALSE TRUE
ENST00000524906 ENSG00000204839 HEK293_OSMI2_6hA HEK293_TMG_6hB MROH6 protein_coding protein_coding 4.510044 3.475657 4.40047 0.1190559 0.3050391 0.3395019 0.2235009 0.27481924 0.00000000 0.17118222 0.00000000 -4.8319747 0.04694167 0.07596667 0.000000000 -0.07596667 0.31314175 0.02159684 FALSE TRUE
ENST00000532704 ENSG00000204839 HEK293_OSMI2_6hA HEK293_TMG_6hB MROH6 protein_coding processed_transcript 4.510044 3.475657 4.40047 0.1190559 0.3050391 0.3395019 0.9407355 0.39309071 0.00000000 0.39309071 0.00000000 -5.3330326 0.18789167 0.11490000 0.000000000 -0.11490000 0.89044031 0.02159684   FALSE
ENST00000533083 ENSG00000204839 HEK293_OSMI2_6hA HEK293_TMG_6hB MROH6 protein_coding retained_intron 4.510044 3.475657 4.40047 0.1190559 0.3050391 0.3395019 0.2049202 0.23286111 0.08314836 0.08670626 0.04541251 -1.3825293 0.04347083 0.06806667 0.018033333 -0.05003333 0.42913950 0.02159684 TRUE FALSE
ENST00000533210 ENSG00000204839 HEK293_OSMI2_6hA HEK293_TMG_6hB MROH6 protein_coding retained_intron 4.510044 3.475657 4.40047 0.1190559 0.3050391 0.3395019 1.1708715 0.72120753 1.56658521 0.14130462 0.22311119 1.1084503 0.26637917 0.20876667 0.352300000 0.14353333 0.36531689 0.02159684 FALSE TRUE
MSTRG.32213.11 ENSG00000204839 HEK293_OSMI2_6hA HEK293_TMG_6hB MROH6 protein_coding   4.510044 3.475657 4.40047 0.1190559 0.3050391 0.3395019 0.4263739 0.33061332 0.49223209 0.09651951 0.14347904 0.5602194 0.09815417 0.09643333 0.111433333 0.01500000 0.96598098 0.02159684 TRUE TRUE
MSTRG.32213.18 ENSG00000204839 HEK293_OSMI2_6hA HEK293_TMG_6hB MROH6 protein_coding   4.510044 3.475657 4.40047 0.1190559 0.3050391 0.3395019 0.4452620 0.06679586 1.23307078 0.06679586 0.12437450 4.0167361 0.09938333 0.01953333 0.279066667 0.25953333 0.02159684 0.02159684 TRUE TRUE
MSTRG.32213.4 ENSG00000204839 HEK293_OSMI2_6hA HEK293_TMG_6hB MROH6 protein_coding   4.510044 3.475657 4.40047 0.1190559 0.3050391 0.3395019 0.0937553 0.39509939 0.03540545 0.24910606 0.03540545 -3.1573386 0.02110417 0.10913333 0.007966667 -0.10116667 0.58653507 0.02159684 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000204839 E001 0.4231520 0.058260286 0.669751290   8 143566192 143566194 3 - 0.126 0.208 0.868
ENSG00000204839 E002 0.7154358 0.392743626 0.898183295   8 143566195 143566197 3 - 0.224 0.273 0.376
ENSG00000204839 E003 2.2833148 0.371433368 0.265092569 0.50441850 8 143566198 143566210 13 - 0.372 0.612 1.193
ENSG00000204839 E004 10.1728640 0.186829682 0.254015886 0.49239498 8 143566211 143566301 91 - 0.932 1.140 0.764
ENSG00000204839 E005 8.5470805 0.164775572 0.290347657 0.53098405 8 143566302 143566319 18 - 0.879 1.063 0.685
ENSG00000204839 E006 17.3492007 0.154389437 0.282164170 0.52252249 8 143566320 143566387 68 - 1.196 1.324 0.449
ENSG00000204839 E007 20.9125063 0.138975133 0.214680515 0.44715804 8 143566388 143566450 63 - 1.255 1.412 0.548
ENSG00000204839 E008 24.2704178 0.233724463 0.255187440 0.49378671 8 143566451 143566517 67 - 1.332 1.459 0.441
ENSG00000204839 E009 23.5960603 0.244122923 0.494719387 0.69724661 8 143566518 143566616 99 - 1.376 1.406 0.104
ENSG00000204839 E010 36.5181503 0.345010515 0.243454888 0.48047961 8 143566617 143567368 752 - 1.490 1.639 0.510
ENSG00000204839 E011 0.6072928 0.019100858 0.905534417   8 143567369 143567371 3 - 0.223 0.209 -0.119
ENSG00000204839 E012 5.4016170 0.138001836 0.268051587 0.50770858 8 143567372 143567465 94 - 0.664 0.912 0.990
ENSG00000204839 E013 6.4049599 0.328797495 0.584474028 0.75997958 8 143567611 143567676 66 - 0.750 0.961 0.815
ENSG00000204839 E014 4.0415908 0.013604773 0.920246557 0.96233964 8 143567677 143567785 109 - 0.701 0.727 0.107
ENSG00000204839 E015 15.1566439 0.027597102 0.160825727 0.37800378 8 143567786 143567888 103 - 1.133 1.282 0.527
ENSG00000204839 E016 11.6598071 0.237921398 0.478893187 0.68638041 8 143567889 143568123 235 - 1.238 0.933 -1.106
ENSG00000204839 E017 3.7500700 0.101521436 0.482414433 0.68865238 8 143568124 143568141 18 - 0.772 0.607 -0.691
ENSG00000204839 E018 5.4410803 0.048936188 0.371129717 0.60479567 8 143568142 143568152 11 - 0.900 0.748 -0.596
ENSG00000204839 E019 12.4046341 0.071831677 0.891755321 0.94749202 8 143568153 143568261 109 - 1.169 1.102 -0.242
ENSG00000204839 E020 9.3073481 0.112198845 0.457965968 0.67172640 8 143568262 143568469 208 - 1.105 0.933 -0.636
ENSG00000204839 E021 6.7114910 0.004935294 0.928803025 0.96646028 8 143568470 143568551 82 - 0.887 0.909 0.084
ENSG00000204839 E022 8.5128872 0.004211280 0.022261671 0.10347561 8 143568552 143568586 35 - 0.827 1.095 1.004
ENSG00000204839 E023 11.4865386 0.016166247 0.038398699 0.15061332 8 143568587 143568719 133 - 0.971 1.213 0.876
ENSG00000204839 E024 7.1472440 0.097646000 0.225248385 0.45967318 8 143568720 143568887 168 - 0.803 1.002 0.758
ENSG00000204839 E025 5.9255400 0.014011889 0.727050223 0.85245096 8 143569441 143569614 174 - 0.805 0.874 0.269
ENSG00000204839 E026 3.5655438 0.024733312 0.270927234 0.51087803 8 143569615 143569696 82 - 0.731 0.578 -0.652
ENSG00000204839 E027 14.8148094 0.056443743 0.786443512 0.88837284 8 143569697 143569840 144 - 1.201 1.197 -0.014
ENSG00000204839 E028 6.1105606 0.025864232 0.076909536 0.23861388 8 143569841 143569890 50 - 0.958 0.727 -0.899
ENSG00000204839 E029 6.5331154 0.006068308 0.002845316 0.02247337 8 143569891 143569950 60 - 1.031 0.673 -1.393
ENSG00000204839 E030 7.4252457 0.020222989 0.031651833 0.13220220 8 143569951 143569952 2 - 1.045 0.795 -0.943
ENSG00000204839 E031 9.5382927 0.009082081 0.053721171 0.18841185 8 143569953 143570065 113 - 1.117 0.925 -0.704
ENSG00000204839 E032 20.0373183 0.198635099 0.309906871 0.55040070 8 143570243 143570380 138 - 1.411 1.225 -0.651
ENSG00000204839 E033 1.4011997 0.018486457 0.009641932 0.05657597 8 143570381 143570417 37 - 0.567 0.117 -3.120
ENSG00000204839 E034 25.4936792 0.146465211 0.164264515 0.38305753 8 143570473 143570657 185 - 1.522 1.311 -0.730
ENSG00000204839 E035 19.9247741 0.002744100 0.138486053 0.34523597 8 143570877 143570994 118 - 1.377 1.284 -0.326
ENSG00000204839 E036 12.6052591 0.057777632 0.891672202 0.94746658 8 143571667 143571809 143 - 1.095 1.175 0.289
ENSG00000204839 E037 5.0118819 0.214357456 0.565242894 0.74687665 8 143571810 143571821 12 - 0.807 0.762 -0.181
ENSG00000204839 E038 14.5941425 0.019027229 0.572881923 0.75226267 8 143572033 143572185 153 - 1.148 1.239 0.324
ENSG00000204839 E039 21.7849593 0.031545715 0.922243070 0.96340892 8 143572421 143572785 365 - 1.333 1.385 0.181