ENSG00000204588

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336905 ENSG00000204588 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01123 lncRNA lncRNA 10.20384 11.28452 9.339671 0.8055916 1.53603 -0.272635 0.9874840 0.0000000 1.3196404 0.00000000 0.1568069 7.0548923 0.09872500 0.00000000 0.1580000 0.15800000 1.189415e-08 1.189415e-08 TRUE FALSE
MSTRG.19021.1 ENSG00000204588 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01123 lncRNA   10.20384 11.28452 9.339671 0.8055916 1.53603 -0.272635 0.3300579 0.7468364 0.1638756 0.40743124 0.1638756 -2.1219262 0.03367083 0.06843333 0.0153000 -0.05313333 7.090817e-01 1.189415e-08   FALSE
MSTRG.19021.2 ENSG00000204588 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01123 lncRNA   10.20384 11.28452 9.339671 0.8055916 1.53603 -0.272635 1.0720601 1.4453750 1.0158725 0.05233412 0.3586846 -0.5045394 0.10449583 0.12973333 0.1005000 -0.02923333 8.329179e-01 1.189415e-08 TRUE FALSE
MSTRG.19021.4 ENSG00000204588 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01123 lncRNA   10.20384 11.28452 9.339671 0.8055916 1.53603 -0.272635 7.3857966 8.7488245 6.4325587 0.95937160 1.3020774 -0.4431035 0.71958750 0.77240000 0.6789667 -0.09343333 6.389879e-01 1.189415e-08   TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000204588 E001 0.0000000       2 109986604 109986706 103 +      
ENSG00000204588 E002 0.1426347 0.032649190 0.328543727   2 109986946 109986976 31 + 0.140 0.000 -11.584
ENSG00000204588 E003 1.4171323 0.013023851 0.671582376 0.81728247 2 109986977 109987011 35 + 0.332 0.420 0.512
ENSG00000204588 E004 7.5737097 0.004621262 0.234534522 0.47034029 2 109987012 109987062 51 + 0.828 0.988 0.607
ENSG00000204588 E005 7.2283408 0.004618574 0.203049088 0.43341384 2 109987063 109987064 2 + 0.802 0.975 0.660
ENSG00000204588 E006 19.1319809 0.192423207 0.351411466 0.58856118 2 109987065 109987190 126 + 1.217 1.348 0.459
ENSG00000204588 E007 19.2628491 0.193798302 0.340382252 0.57828445 2 109987561 109987806 246 + 1.217 1.352 0.474
ENSG00000204588 E008 0.6064850 0.022286802 0.090645798   2 109987807 109988170 364 + 0.000 0.320 14.065
ENSG00000204588 E009 0.4644705 0.025370987 0.172140860   2 109988171 109988271 101 + 0.000 0.259 13.696
ENSG00000204588 E010 49.8128998 0.055484727 0.282768726 0.52320317 2 109988272 109988802 531 + 1.715 1.685 -0.101
ENSG00000204588 E011 0.3751086 0.024896255 0.342884682   2 109992153 109992334 182 + 0.000 0.189 13.175
ENSG00000204588 E012 0.0000000       2 109993610 109993634 25 +      
ENSG00000204588 E013 0.0000000       2 109993635 109993662 28 +      
ENSG00000204588 E014 0.0000000       2 109993663 109993667 5 +      
ENSG00000204588 E015 0.0000000       2 109993668 109993708 41 +      
ENSG00000204588 E016 0.0000000       2 109993709 109993750 42 +      
ENSG00000204588 E017 0.0000000       2 109993751 109993753 3 +      
ENSG00000204588 E018 0.0000000       2 109993754 109993785 32 +      
ENSG00000204588 E019 0.2027342 0.037030779 0.726236917   2 109993786 109993819 34 + 0.000 0.105 12.244
ENSG00000204588 E020 12.5633283 0.002775858 0.130729952 0.33292773 2 109994401 109995634 1234 + 1.023 1.189 0.596
ENSG00000204588 E021 1.8503152 0.011684751 0.375227661 0.60836798 2 109995635 109995674 40 + 0.332 0.503 0.929
ENSG00000204588 E022 1.4174220 0.014445520 0.008569644 0.05191092 2 109995675 109995714 40 + 0.000 0.503 14.945
ENSG00000204588 E023 1.1719641 0.015542954 0.889756438   2 109995715 109995754 40 + 0.332 0.320 -0.071
ENSG00000204588 E024 3.2361305 0.009132097 0.078899784 0.24262559 2 109995755 109995794 40 + 0.747 0.502 -1.072
ENSG00000204588 E025 0.2617363 0.308956938 0.440587102   2 109995795 109995834 40 + 0.000 0.183 12.979
ENSG00000204588 E026 0.5233527 0.022427073 0.359568596   2 109995835 109995874 40 + 0.247 0.105 -1.487
ENSG00000204588 E027 1.1480216 0.015378759 0.013793914   2 109995875 109995914 40 + 0.517 0.105 -3.072
ENSG00000204588 E028 3.1358099 0.009132097 0.014463365 0.07611677 2 109995915 109995954 40 + 0.776 0.421 -1.601
ENSG00000204588 E029 1.5428389 0.014818581 0.213757143 0.44607229 2 109995955 109995994 40 + 0.518 0.320 -1.077
ENSG00000204588 E030 1.9011917 0.072146677 0.928350938 0.96619114 2 109995995 109996034 40 + 0.463 0.462 -0.003
ENSG00000204588 E031 3.4266887 0.017532790 0.001303715 0.01219167 2 109996035 109996074 40 + 0.852 0.374 -2.161
ENSG00000204588 E032 1.3496583 0.019916773 0.024573573   2 109996075 109996114 40 + 0.565 0.188 -2.299
ENSG00000204588 E033 0.7429626 0.110924036 0.410830594   2 109996115 109996264 150 + 0.141 0.316 1.480