ENSG00000204569

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376511 ENSG00000204569 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1R10 protein_coding protein_coding 40.96882 46.86669 23.72019 4.938128 1.132187 -0.9821473 33.734498 39.566986 21.1300348 5.0787250 0.7358049 -0.904684 0.84278333 0.8397333 0.8919667 0.05223333 0.5811578697 0.0007094172 FALSE TRUE
MSTRG.27905.1 ENSG00000204569 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1R10 protein_coding   40.96882 46.86669 23.72019 4.938128 1.132187 -0.9821473 4.548434 3.909433 0.3200893 0.5259471 0.1080318 -3.569716 0.08529583 0.0829000 0.0139000 -0.06900000 0.0007094172 0.0007094172 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000204569 E001 7.1109294 0.0076677898 4.002658e-03 2.917354e-02 6 30600295 30600412 118 - 0.462 0.999 2.243
ENSG00000204569 E002 22.8628608 0.0057089484 4.122145e-04 4.849231e-03 6 30600413 30600464 52 - 1.000 1.449 1.590
ENSG00000204569 E003 98.9152552 0.4380060088 1.512119e-01 3.640898e-01 6 30600465 30600492 28 - 1.658 2.057 1.345
ENSG00000204569 E004 284.5155814 1.0630174014 2.899566e-01 5.305432e-01 6 30600493 30600657 165 - 2.106 2.513 1.360
ENSG00000204569 E005 611.6606804 1.3945989766 3.908431e-01 6.210212e-01 6 30600658 30601097 440 - 2.488 2.835 1.158
ENSG00000204569 E006 310.7905794 1.1746158455 3.995163e-01 6.278822e-01 6 30601098 30601242 145 - 2.229 2.535 1.021
ENSG00000204569 E007 203.4966603 1.0082610396 3.676490e-01 6.021298e-01 6 30601243 30601305 63 - 2.045 2.352 1.028
ENSG00000204569 E008 474.3312333 1.3012477383 3.815095e-01 6.134855e-01 6 30601306 30601658 353 - 2.380 2.725 1.149
ENSG00000204569 E009 366.2278292 1.2156790937 3.775841e-01 6.103065e-01 6 30601936 30602148 213 - 2.276 2.611 1.116
ENSG00000204569 E010 176.5560386 0.9796060007 4.054048e-01 6.326284e-01 6 30602149 30602196 48 - 2.010 2.284 0.917
ENSG00000204569 E011 166.6398317 0.9778006818 4.352935e-01 6.551994e-01 6 30602197 30602244 48 - 2.012 2.253 0.806
ENSG00000204569 E012 213.7192984 1.0192639670 3.600074e-01 5.957403e-01 6 30602245 30602334 90 - 2.060 2.375 1.053
ENSG00000204569 E013 164.4304401 0.8891590846 3.070457e-01 5.476448e-01 6 30602335 30602382 48 - 1.922 2.267 1.154
ENSG00000204569 E014 331.5959595 1.1389122663 3.173113e-01 5.572929e-01 6 30602383 30602691 309 - 2.191 2.576 1.285
ENSG00000204569 E015 220.1952438 1.0204283012 3.464889e-01 5.840723e-01 6 30602846 30602959 114 - 2.059 2.390 1.106
ENSG00000204569 E016 208.0808900 0.0002859221 3.863187e-01 6.175652e-01 6 30603210 30603285 76 - 2.193 2.325 0.441
ENSG00000204569 E017 275.4168598 0.0011406186 1.198358e-03 1.142089e-02 6 30603472 30603572 101 - 2.395 2.414 0.064
ENSG00000204569 E018 223.0918287 0.0067503650 7.543519e-03 4.722819e-02 6 30603573 30603666 94 - 2.322 2.314 -0.026
ENSG00000204569 E019 1.6364347 0.0121989077 8.065107e-01 9.000490e-01 6 30603667 30603779 113 - 0.384 0.404 0.111
ENSG00000204569 E020 199.3228465 0.0119441812 9.584198e-03 5.632865e-02 6 30603780 30603843 64 - 2.291 2.258 -0.108
ENSG00000204569 E021 385.2641331 0.0117063095 3.884092e-02 1.517247e-01 6 30604008 30604254 247 - 2.547 2.556 0.031
ENSG00000204569 E022 350.1673053 0.0157738618 3.371776e-02 1.381136e-01 6 30604353 30604511 159 - 2.519 2.509 -0.033
ENSG00000204569 E023 165.7813729 0.0189067885 2.628295e-02 1.161570e-01 6 30604588 30604611 24 - 2.213 2.178 -0.118
ENSG00000204569 E024 276.7689995 0.0140983913 5.560999e-02 1.927241e-01 6 30604612 30604735 124 - 2.408 2.412 0.014
ENSG00000204569 E025 15.6610267 0.1825492975 5.496863e-02 1.912699e-01 6 30604736 30604993 258 - 1.339 1.099 -0.850
ENSG00000204569 E026 136.8329293 0.0174607945 1.385638e-01 3.453366e-01 6 30604994 30605017 24 - 2.097 2.110 0.044
ENSG00000204569 E027 180.5506995 0.0279681467 2.300364e-01 4.651869e-01 6 30605018 30605094 77 - 2.212 2.232 0.064
ENSG00000204569 E028 2.2432950 0.0265535996 4.785032e-01 6.860672e-01 6 30605809 30605922 114 - 0.528 0.473 -0.264
ENSG00000204569 E029 231.8433855 0.0264341457 1.329647e-01 3.364641e-01 6 30605923 30606035 113 - 2.335 2.333 -0.005
ENSG00000204569 E030 247.0416803 0.0356982147 1.597541e-01 3.764332e-01 6 30606138 30606243 106 - 2.368 2.358 -0.035
ENSG00000204569 E031 309.2623585 0.0274607753 7.159465e-02 2.280188e-01 6 30606468 30606641 174 - 2.475 2.450 -0.083
ENSG00000204569 E032 0.5834523 0.4520850426 7.358319e-01   6 30606642 30606737 96 - 0.171 0.165 -0.056
ENSG00000204569 E033 205.1294116 0.0138813394 6.601438e-03 4.271056e-02 6 30606779 30606856 78 - 2.314 2.265 -0.162
ENSG00000204569 E034 178.1235731 0.0123169785 3.510354e-05 6.167379e-04 6 30607840 30607891 52 - 2.304 2.176 -0.429
ENSG00000204569 E035 257.1980580 0.0165014159 3.378075e-03 2.562879e-02 6 30608779 30608914 136 - 2.426 2.356 -0.234
ENSG00000204569 E036 203.1281161 0.0116342055 2.601077e-03 2.097051e-02 6 30609077 30609163 87 - 2.312 2.260 -0.175
ENSG00000204569 E037 234.9761035 0.0121043344 1.658821e-03 1.473358e-02 6 30609838 30609946 109 - 2.380 2.320 -0.199
ENSG00000204569 E038 119.1214765 0.0172626626 1.955059e-02 9.436239e-02 6 30609947 30609955 9 - 2.077 2.031 -0.155
ENSG00000204569 E039 3.5539496 0.0070663727 1.528250e-01 3.663797e-01 6 30614549 30614602 54 - 0.722 0.586 -0.582
ENSG00000204569 E040 190.6433131 0.0148723064 1.561389e-02 8.040751e-02 6 30616478 30616583 106 - 2.272 2.239 -0.111
ENSG00000204569 E041 273.1416685 0.0087599882 5.927307e-05 9.634314e-04 6 30616584 30616998 415 - 2.460 2.379 -0.270
ENSG00000204569 E042 0.8746386 0.0445647045 2.251688e-01   6 30617092 30617223 132 - 0.384 0.218 -1.126
ENSG00000204569 E043 17.9360161 0.0020380531 1.911754e-06 5.016376e-05 6 30617224 30617280 57 - 1.425 1.137 -1.010
ENSG00000204569 E044 0.1723744 0.0439721452 1.000000e+00   6 30617989 30618035 47 - 0.000 0.086 8.550
ENSG00000204569 E045 0.3751086 0.0278629570 6.801104e-01   6 30618558 30618697 140 - 0.000 0.158 9.552