ENSG00000204406

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000470063 ENSG00000204406 HEK293_OSMI2_6hA HEK293_TMG_6hB MBD5 protein_coding processed_transcript 4.054542 3.716708 5.225448 0.7200124 0.08649773 0.4904112 0.5199407 0.9283987 0.6497353 0.63014895 0.64973533 -0.50831368 0.12192083 0.23456667 0.12300000 -0.11156667 6.915773e-01 3.12888e-09 FALSE FALSE
ENST00000473478 ENSG00000204406 HEK293_OSMI2_6hA HEK293_TMG_6hB MBD5 protein_coding processed_transcript 4.054542 3.716708 5.225448 0.7200124 0.08649773 0.4904112 0.3909514 0.1903887 0.6718784 0.10547694 0.33899275 1.76671309 0.09463333 0.06026667 0.12910000 0.06883333 9.436008e-01 3.12888e-09 TRUE FALSE
ENST00000478190 ENSG00000204406 HEK293_OSMI2_6hA HEK293_TMG_6hB MBD5 protein_coding processed_transcript 4.054542 3.716708 5.225448 0.7200124 0.08649773 0.4904112 0.3482257 0.1937874 0.1953607 0.03644378 0.01333215 0.01109561 0.10545833 0.05236667 0.03733333 -0.01503333 8.088743e-01 3.12888e-09 FALSE FALSE
ENST00000496158 ENSG00000204406 HEK293_OSMI2_6hA HEK293_TMG_6hB MBD5 protein_coding processed_transcript 4.054542 3.716708 5.225448 0.7200124 0.08649773 0.4904112 0.3639031 0.0000000 0.8982687 0.00000000 0.09296614 6.50504722 0.07988750 0.00000000 0.17220000 0.17220000 3.128880e-09 3.12888e-09   FALSE
ENST00000627651 ENSG00000204406 HEK293_OSMI2_6hA HEK293_TMG_6hB MBD5 protein_coding protein_coding 4.054542 3.716708 5.225448 0.7200124 0.08649773 0.4904112 0.3864610 0.5118985 0.6105395 0.09188763 0.05679467 0.24975378 0.09992917 0.13950000 0.11716667 -0.02233333 8.825437e-01 3.12888e-09 FALSE TRUE
ENST00000637997 ENSG00000204406 HEK293_OSMI2_6hA HEK293_TMG_6hB MBD5 protein_coding processed_transcript 4.054542 3.716708 5.225448 0.7200124 0.08649773 0.4904112 0.1866270 0.2608558 0.1298645 0.06201408 0.03823581 -0.95349560 0.06187917 0.06866667 0.02506667 -0.04360000 2.664560e-01 3.12888e-09 TRUE FALSE
ENST00000642680 ENSG00000204406 HEK293_OSMI2_6hA HEK293_TMG_6hB MBD5 protein_coding protein_coding 4.054542 3.716708 5.225448 0.7200124 0.08649773 0.4904112 0.9120662 1.0012569 1.0257512 0.21637505 0.02726810 0.03452797 0.24652500 0.26903333 0.19626667 -0.07276667 6.233077e-01 3.12888e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000204406 E001 0.2027342 0.0350410582 0.5488515437   2 148021011 148021026 16 + 0.000 0.116 10.222
ENSG00000204406 E002 0.8701267 0.0170190675 0.2269812973   2 148021027 148021046 20 + 0.128 0.346 1.837
ENSG00000204406 E003 17.7219840 0.0169946557 0.2014077057 0.431439502 2 148021091 148021237 147 + 1.196 1.334 0.484
ENSG00000204406 E004 24.4133592 0.0014737439 0.0127676396 0.069510430 2 148021238 148021392 155 + 1.297 1.489 0.666
ENSG00000204406 E005 11.9182606 0.0032588209 0.2619115541 0.501009325 2 148021393 148021416 24 + 1.051 1.176 0.449
ENSG00000204406 E006 10.5244737 0.0035319670 0.4940900177 0.696741226 2 148021417 148021436 20 + 1.024 1.109 0.311
ENSG00000204406 E007 5.3201052 0.0339936106 0.9998111329 1.000000000 2 148021437 148021442 6 + 0.808 0.811 0.011
ENSG00000204406 E008 4.9924198 0.0989350663 0.8609607253 0.930847015 2 148021443 148021448 6 + 0.806 0.780 -0.100
ENSG00000204406 E009 3.7736297 0.1856000717 0.4993100510 0.700325786 2 148021449 148021450 2 + 0.604 0.756 0.638
ENSG00000204406 E010 3.6012553 0.1510111563 0.5562250606 0.740646310 2 148021451 148021454 4 + 0.605 0.733 0.542
ENSG00000204406 E011 6.3279971 0.1176708276 0.4258950302 0.647927622 2 148021455 148021482 28 + 0.801 0.929 0.492
ENSG00000204406 E012 7.3995728 0.1344600661 0.2809294906 0.521185671 2 148021483 148021505 23 + 0.822 1.010 0.713
ENSG00000204406 E013 20.2086123 0.3580050014 0.2390046856 0.475481095 2 148021506 148021592 87 + 1.171 1.428 0.899
ENSG00000204406 E014 13.8874602 0.2765788375 0.2738873311 0.513823913 2 148021593 148021603 11 + 1.041 1.262 0.790
ENSG00000204406 E015 16.2971677 0.1786954703 0.2976489951 0.538158839 2 148021604 148021629 26 + 1.123 1.319 0.690
ENSG00000204406 E016 14.4053078 0.0679584359 0.5902620196 0.763930870 2 148021630 148021647 18 + 1.148 1.221 0.260
ENSG00000204406 E017 21.2086639 0.0581405873 0.2917508391 0.532426392 2 148021648 148021684 37 + 1.273 1.405 0.461
ENSG00000204406 E018 0.0000000       2 148021756 148021782 27 +      
ENSG00000204406 E019 16.3828158 0.0019983991 0.6908447271 0.829594224 2 148024966 148028649 3684 + 1.214 1.264 0.175
ENSG00000204406 E020 0.3032425 0.0274424043 0.2436158838   2 148041206 148041365 160 + 0.000 0.206 13.753
ENSG00000204406 E021 2.0390879 0.2185555571 0.3901264616 0.620590128 2 148053933 148054050 118 + 0.371 0.590 1.099
ENSG00000204406 E022 4.4431158 0.0160008126 0.1538446092 0.367816623 2 148054391 148054449 59 + 0.610 0.831 0.912
ENSG00000204406 E023 0.3206185 0.0274424043 0.1667494513   2 148054450 148055452 1003 + 0.226 0.000 -14.760
ENSG00000204406 E024 0.3807181 0.0336302987 0.9154107055   2 148055453 148056141 689 + 0.128 0.116 -0.164
ENSG00000204406 E025 0.1779838 0.0372051639 0.4317528308   2 148068562 148068571 10 + 0.128 0.000 -13.776
ENSG00000204406 E026 0.3088520 0.0262368714 0.9114789800   2 148068572 148068593 22 + 0.128 0.115 -0.170
ENSG00000204406 E027 4.0668056 0.0232448390 0.0428342687 0.162114596 2 148070873 148072063 1191 + 0.484 0.815 1.433
ENSG00000204406 E028 14.9364258 0.0044961834 0.1690785715 0.389388160 2 148178700 148178793 94 + 1.265 1.158 -0.379
ENSG00000204406 E029 0.0000000       2 148196208 148196235 28 +      
ENSG00000204406 E030 0.1426347 0.0323727165 0.4325422073   2 148219947 148220033 87 + 0.128 0.000 -13.798
ENSG00000204406 E031 14.6785814 0.0026739249 0.0079942145 0.049281309 2 148233245 148233347 103 + 1.297 1.078 -0.778
ENSG00000204406 E032 9.9929181 0.0094612820 0.0513744189 0.183009020 2 148233348 148233395 48 + 1.135 0.935 -0.734
ENSG00000204406 E033 0.0000000       2 148243711 148244368 658 +      
ENSG00000204406 E034 0.0000000       2 148264179 148265070 892 +      
ENSG00000204406 E035 0.0000000       2 148330483 148330505 23 +      
ENSG00000204406 E036 0.0000000       2 148330506 148330600 95 +      
ENSG00000204406 E037 16.3474419 0.0023853460 0.0014411472 0.013197085 2 148342214 148342336 123 + 1.359 1.109 -0.882
ENSG00000204406 E038 0.0000000       2 148346022 148347611 1590 +      
ENSG00000204406 E039 0.0000000       2 148393301 148393375 75 +      
ENSG00000204406 E040 0.1308682 0.0326491905 0.5517702220   2 148447567 148447740 174 + 0.000 0.115 12.787
ENSG00000204406 E041 25.0796287 0.0021712019 0.0020549684 0.017428131 2 148458203 148458446 244 + 1.515 1.317 -0.684
ENSG00000204406 E042 31.9081421 0.0049230130 0.1870330806 0.413090374 2 148458447 148458871 425 + 1.555 1.483 -0.247
ENSG00000204406 E043 0.5474829 0.2372571742 0.1340163879   2 148460219 148460291 73 + 0.000 0.287 13.783
ENSG00000204406 E044 14.3869513 0.0022922143 0.0393658579 0.153137741 2 148462582 148462684 103 + 1.266 1.099 -0.591
ENSG00000204406 E045 18.0862264 0.0022399798 0.3800009285 0.612170111 2 148463739 148463919 181 + 1.304 1.249 -0.192
ENSG00000204406 E046 31.9228200 0.0081963758 0.5679081359 0.748733366 2 148468341 148468724 384 + 1.532 1.503 -0.098
ENSG00000204406 E047 51.3674967 0.0010709601 0.0003176925 0.003908561 2 148468725 148469507 783 + 1.798 1.642 -0.529
ENSG00000204406 E048 71.1541272 0.0006403445 0.3482289835 0.585691689 2 148469508 148470461 954 + 1.828 1.884 0.187
ENSG00000204406 E049 21.5005651 0.0017527076 0.8979117097 0.950779775 2 148470462 148472455 1994 + 1.339 1.366 0.092
ENSG00000204406 E050 0.4054685 0.4784255365 0.3586028338   2 148481737 148481792 56 + 0.000 0.216 12.979
ENSG00000204406 E051 17.2439341 0.0025496025 0.4956922674 0.697957432 2 148483110 148483436 327 + 1.281 1.241 -0.141
ENSG00000204406 E052 16.9908941 0.0019757902 0.1321376813 0.335188493 2 148483437 148483814 378 + 1.176 1.318 0.498
ENSG00000204406 E053 14.6724720 0.0024733364 0.9061002773 0.955150572 2 148483815 148484135 321 + 1.176 1.202 0.092
ENSG00000204406 E054 1.2545489 0.0295216294 0.2438616438   2 148485116 148485741 626 + 0.227 0.450 1.409
ENSG00000204406 E055 17.3980792 0.0021899460 0.4859461267 0.691214736 2 148485742 148485950 209 + 1.289 1.249 -0.141
ENSG00000204406 E056 13.6700062 0.0035371609 0.3672171600 0.601727362 2 148489386 148489500 115 + 1.196 1.130 -0.236
ENSG00000204406 E057 50.1300213 0.0365067616 0.7155025046 0.845219685 2 148489501 148490433 933 + 1.709 1.704 -0.018
ENSG00000204406 E058 19.4888501 0.0512360182 0.9766012132 0.990056698 2 148490434 148490594 161 + 1.295 1.311 0.054
ENSG00000204406 E059 1.3581302 0.0268226121 0.6202641504   2 148490595 148490787 193 + 0.306 0.403 0.581
ENSG00000204406 E060 1.7565318 0.0105567399 0.9663135940 0.985049032 2 148502397 148502435 39 + 0.433 0.451 0.097
ENSG00000204406 E061 10.4051615 0.0058938561 0.4650489595 0.676600297 2 148502436 148502442 7 + 0.995 1.089 0.342
ENSG00000204406 E062 17.1401177 0.0099554217 0.9909318394 0.997191333 2 148502443 148502509 67 + 1.242 1.258 0.056
ENSG00000204406 E063 0.1723744 0.0564274928 0.5480915809   2 148502965 148502994 30 + 0.000 0.116 12.698
ENSG00000204406 E064 0.1723744 0.0564274928 0.5480915809   2 148502995 148503021 27 + 0.000 0.116 12.698
ENSG00000204406 E065 15.4125380 0.0029570442 0.3628160589 0.598001743 2 148510060 148510135 76 + 1.167 1.263 0.341
ENSG00000204406 E066 0.3559677 0.5523578383 0.2983062035   2 148512234 148512259 26 + 0.232 0.000 -13.703
ENSG00000204406 E067 43.3582832 0.0008209424 0.5027108206 0.702636260 2 148512870 148516971 4102 + 1.620 1.672 0.177