ENSG00000204394

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375663 ENSG00000204394 HEK293_OSMI2_6hA HEK293_TMG_6hB VARS1 protein_coding protein_coding 107.4093 155.7413 78.58635 22.11114 3.88369 -0.9867098 66.135185 108.0345442 34.823844 20.2492254 0.9637576 -1.633065 0.58721667 0.6832000000 0.4450667 -0.23813333 8.907544e-03 6.977805e-09 FALSE TRUE
ENST00000428445 ENSG00000204394 HEK293_OSMI2_6hA HEK293_TMG_6hB VARS1 protein_coding protein_coding 107.4093 155.7413 78.58635 22.11114 3.88369 -0.9867098 9.351528 13.1758016 5.353085 4.3239917 1.2881788 -1.297850 0.07647083 0.0794333333 0.0671000 -0.01233333 9.493075e-01 6.977805e-09 FALSE FALSE
ENST00000440048 ENSG00000204394 HEK293_OSMI2_6hA HEK293_TMG_6hB VARS1 protein_coding protein_coding 107.4093 155.7413 78.58635 22.11114 3.88369 -0.9867098 5.267174 7.4784055 4.704529 0.8372946 0.3901807 -0.667545 0.05336667 0.0486000000 0.0600000 0.01140000 6.757722e-01 6.977805e-09 FALSE FALSE
ENST00000495010 ENSG00000204394 HEK293_OSMI2_6hA HEK293_TMG_6hB VARS1 protein_coding retained_intron 107.4093 155.7413 78.58635 22.11114 3.88369 -0.9867098 2.860324 0.0817159 8.162942 0.0817159 0.4227258 6.477540 0.03650417 0.0004333333 0.1039000 0.10346667 6.977805e-09 6.977805e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000204394 E001 364.1099370 1.182883e-03 1.532761e-03 1.383534e-02 6 31777518 31777662 145 - 2.419 2.514 0.316
ENSG00000204394 E002 28.3245890 1.151124e-01 2.688451e-02 1.179530e-01 6 31777936 31778182 247 - 1.651 1.277 -1.287
ENSG00000204394 E003 831.1233530 2.800030e-03 2.790238e-07 9.255070e-06 6 31778967 31779229 263 - 2.719 2.881 0.538
ENSG00000204394 E004 553.6464426 2.633985e-03 7.846061e-07 2.300486e-05 6 31779230 31779292 63 - 2.542 2.705 0.544
ENSG00000204394 E005 794.6823666 3.313958e-03 7.060537e-06 1.549235e-04 6 31779425 31779536 112 - 2.709 2.859 0.500
ENSG00000204394 E006 1115.8092716 9.806390e-04 4.529148e-06 1.057110e-04 6 31779608 31779814 207 - 2.902 2.997 0.315
ENSG00000204394 E007 16.8485463 1.356002e-02 1.952444e-04 2.623423e-03 6 31779815 31779997 183 - 1.441 1.074 -1.294
ENSG00000204394 E008 985.3554750 2.079373e-04 1.203543e-04 1.741855e-03 6 31779998 31780153 156 - 2.876 2.938 0.204
ENSG00000204394 E009 457.1752573 7.633825e-04 4.450901e-01 6.621801e-01 6 31780441 31780454 14 - 2.573 2.595 0.073
ENSG00000204394 E010 832.1836138 1.156572e-04 7.267362e-04 7.666575e-03 6 31780455 31780550 96 - 2.808 2.864 0.186
ENSG00000204394 E011 500.1875034 1.152977e-04 4.577907e-02 1.694601e-01 6 31780551 31780568 18 - 2.598 2.641 0.142
ENSG00000204394 E012 781.9687627 9.735159e-05 2.891166e-01 5.296434e-01 6 31780705 31780783 79 - 2.809 2.829 0.068
ENSG00000204394 E013 447.2468211 1.682308e-03 2.171328e-01 4.499974e-01 6 31780870 31780876 7 - 2.602 2.573 -0.098
ENSG00000204394 E014 424.6033072 1.599181e-03 1.484441e-01 3.600366e-01 6 31780877 31780877 1 - 2.584 2.549 -0.116
ENSG00000204394 E015 742.6216510 5.096660e-04 9.247283e-01 9.647014e-01 6 31780878 31780938 61 - 2.799 2.801 0.007
ENSG00000204394 E016 971.0895663 1.555385e-04 3.893015e-01 6.199467e-01 6 31781019 31781123 105 - 2.905 2.921 0.052
ENSG00000204394 E017 23.4724472 8.893430e-02 3.193455e-02 1.330220e-01 6 31781124 31781357 234 - 1.563 1.209 -1.226
ENSG00000204394 E018 16.1305571 1.547479e-01 1.330469e-01 3.365922e-01 6 31781358 31781480 123 - 1.362 1.086 -0.977
ENSG00000204394 E019 962.4200414 1.258725e-04 4.370350e-01 6.564729e-01 6 31781481 31781606 126 - 2.902 2.917 0.049
ENSG00000204394 E020 14.7472609 5.983424e-02 5.566665e-03 3.755913e-02 6 31781607 31781690 84 - 1.403 1.002 -1.424
ENSG00000204394 E021 455.9879491 1.695099e-04 8.408266e-01 9.199014e-01 6 31781691 31781692 2 - 2.590 2.590 -0.001
ENSG00000204394 E022 473.3470888 1.333997e-04 7.535537e-01 8.688648e-01 6 31781693 31781699 7 - 2.599 2.609 0.035
ENSG00000204394 E023 661.6318739 1.286997e-04 3.028029e-01 5.433756e-01 6 31781700 31781761 62 - 2.735 2.756 0.071
ENSG00000204394 E024 20.6216321 8.973455e-02 2.507049e-02 1.124490e-01 6 31781762 31781846 85 - 1.510 1.150 -1.254
ENSG00000204394 E025 755.1797929 9.927860e-05 2.994215e-02 1.271731e-01 6 31781847 31781952 106 - 2.781 2.819 0.128
ENSG00000204394 E026 17.9352843 8.322601e-02 9.717443e-02 2.768125e-01 6 31782041 31782086 46 - 1.396 1.129 -0.937
ENSG00000204394 E027 644.3400478 1.169365e-04 8.399474e-03 5.115359e-02 6 31782087 31782177 91 - 2.703 2.752 0.163
ENSG00000204394 E028 11.0111206 1.088184e-01 2.521989e-02 1.128791e-01 6 31782178 31782284 107 - 1.279 0.884 -1.437
ENSG00000204394 E029 653.4730546 2.353595e-04 2.513569e-03 2.041815e-02 6 31782285 31782401 117 - 2.703 2.761 0.194
ENSG00000204394 E030 308.6880846 9.962032e-04 2.278554e-01 4.628424e-01 6 31782402 31782411 10 - 2.394 2.432 0.126
ENSG00000204394 E031 417.6653487 2.711702e-04 7.566087e-01 8.705813e-01 6 31782412 31782443 32 - 2.546 2.557 0.034
ENSG00000204394 E032 25.1210950 9.855395e-02 2.188945e-03 1.833094e-02 6 31782444 31782529 86 - 1.670 1.168 -1.741
ENSG00000204394 E033 645.9726860 1.113153e-04 1.871044e-01 4.131780e-01 6 31782530 31782633 104 - 2.722 2.749 0.088
ENSG00000204394 E034 47.4002881 5.518892e-02 1.865911e-02 9.126308e-02 6 31782634 31782720 87 - 1.822 1.524 -1.010
ENSG00000204394 E035 792.6535752 5.444453e-04 2.693584e-01 5.091578e-01 6 31782721 31782845 125 - 2.844 2.824 -0.066
ENSG00000204394 E036 699.6756938 4.344494e-04 3.538335e-05 6.208830e-04 6 31783096 31783186 91 - 2.829 2.756 -0.243
ENSG00000204394 E037 6.7858055 1.564731e-02 2.153066e-02 1.010698e-01 6 31783187 31783239 53 - 1.036 0.726 -1.190
ENSG00000204394 E038 712.0524966 1.554118e-04 6.424675e-05 1.032123e-03 6 31784214 31784308 95 - 2.829 2.768 -0.202
ENSG00000204394 E039 672.2421254 5.997774e-04 1.077898e-04 1.591755e-03 6 31784394 31784502 109 - 2.812 2.738 -0.247
ENSG00000204394 E040 300.3174551 3.598882e-03 1.015173e-02 5.877414e-02 6 31784595 31784597 3 - 2.479 2.380 -0.331
ENSG00000204394 E041 684.0190362 1.204271e-03 3.989955e-04 4.722183e-03 6 31784598 31784714 117 - 2.824 2.743 -0.271
ENSG00000204394 E042 581.8994658 8.840561e-04 3.631176e-03 2.710021e-02 6 31785246 31785327 82 - 2.743 2.678 -0.215
ENSG00000204394 E043 786.5217587 5.789028e-04 2.698360e-04 3.425490e-03 6 31785569 31785733 165 - 2.876 2.809 -0.221
ENSG00000204394 E044 700.1273515 1.041589e-03 9.596165e-03 5.637735e-02 6 31791610 31791737 128 - 2.818 2.761 -0.189
ENSG00000204394 E045 551.9712925 3.099177e-04 1.709506e-02 8.581029e-02 6 31791871 31791971 101 - 2.706 2.665 -0.139
ENSG00000204394 E046 6.2760002 4.580502e-02 2.444190e-01 4.815589e-01 6 31791972 31792091 120 - 0.934 0.741 -0.751
ENSG00000204394 E047 601.4630849 1.003688e-03 1.467917e-02 7.688873e-02 6 31792217 31792301 85 - 2.749 2.696 -0.177
ENSG00000204394 E048 46.9858396 1.042870e-03 1.512536e-02 7.856777e-02 6 31792302 31792304 3 - 1.711 1.574 -0.467
ENSG00000204394 E049 748.1685388 1.371383e-04 2.060396e-09 1.132371e-07 6 31792392 31792516 125 - 2.871 2.783 -0.293
ENSG00000204394 E050 710.7007149 3.485658e-04 9.963425e-07 2.832304e-05 6 31792757 31792895 139 - 2.844 2.761 -0.276
ENSG00000204394 E051 0.8092192 1.786058e-02 2.141934e-01   6 31792896 31792960 65 - 0.001 0.278 8.835
ENSG00000204394 E052 414.0311627 1.721927e-04 4.910972e-03 3.415357e-02 6 31792986 31793120 135 - 2.591 2.538 -0.177
ENSG00000204394 E053 2.4218990 8.902725e-03 5.530408e-02 1.920119e-01 6 31794045 31794086 42 - 0.704 0.387 -1.496
ENSG00000204394 E054 792.1260506 5.396849e-04 5.913696e-03 3.931729e-02 6 31794831 31795250 420 - 2.788 2.840 0.172
ENSG00000204394 E055 105.1352419 6.749228e-03 2.772879e-04 3.501366e-03 6 31795251 31795499 249 - 2.101 1.900 -0.677
ENSG00000204394 E056 358.8189454 3.441865e-03 1.376719e-01 3.439584e-01 6 31795546 31795902 357 - 2.443 2.496 0.177