ENSG00000204237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374741 ENSG00000204237 HEK293_OSMI2_6hA HEK293_TMG_6hB OXLD1 protein_coding protein_coding 50.41574 85.44789 16.32621 16.57164 0.933755 -2.38714 21.262208 40.084960 3.9324886 10.0764867 0.2514737 -3.3462424 0.38060000 0.45546667 0.24136667 -0.21410000 0.007799856 0.007799856 FALSE TRUE
ENST00000571757 ENSG00000204237 HEK293_OSMI2_6hA HEK293_TMG_6hB OXLD1 protein_coding nonsense_mediated_decay 50.41574 85.44789 16.32621 16.57164 0.933755 -2.38714 3.003942 5.605998 0.8152991 1.8443590 0.1726770 -2.7665535 0.05000833 0.06226667 0.04933333 -0.01293333 0.914874789 0.007799856   FALSE
ENST00000573786 ENSG00000204237 HEK293_OSMI2_6hA HEK293_TMG_6hB OXLD1 protein_coding processed_transcript 50.41574 85.44789 16.32621 16.57164 0.933755 -2.38714 1.562152 2.279707 2.0140962 0.5642481 0.6070160 -0.1778853 0.04480833 0.02796667 0.12006667 0.09210000 0.025771346 0.007799856   FALSE
ENST00000575963 ENSG00000204237 HEK293_OSMI2_6hA HEK293_TMG_6hB OXLD1 protein_coding retained_intron 50.41574 85.44789 16.32621 16.57164 0.933755 -2.38714 15.339863 23.315787 8.2873210 1.9252064 0.3368620 -1.4912082 0.35588333 0.29733333 0.50913333 0.21180000 0.209365752 0.007799856   FALSE
ENST00000575992 ENSG00000204237 HEK293_OSMI2_6hA HEK293_TMG_6hB OXLD1 protein_coding nonsense_mediated_decay 50.41574 85.44789 16.32621 16.57164 0.933755 -2.38714 5.672116 10.255401 1.1076098 3.3740726 0.1900435 -3.1993015 0.11137917 0.11236667 0.06923333 -0.04313333 0.593186584 0.007799856   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000204237 E001 7.392789 0.9069688678 1.000000e+00 1.0000000000 17 81665036 81665055 20 - 0.442 0.773 1.483
ENSG00000204237 E002 62.400612 0.0006900767 1.000000e+00 1.0000000000 17 81665056 81665100 45 - 1.626 1.603 -0.081
ENSG00000204237 E003 142.201363 0.0003439282 1.649102e-01 0.3838900893 17 81665101 81665140 40 - 1.927 1.961 0.114
ENSG00000204237 E004 148.835601 0.0003219893 2.008849e-01 0.4308357713 17 81665141 81665155 15 - 1.955 1.982 0.091
ENSG00000204237 E005 505.485103 0.0031028591 1.052005e-01 0.2910040892 17 81665156 81665460 305 - 2.479 2.503 0.082
ENSG00000204237 E006 358.458980 0.0023974732 1.940374e-01 0.4221786819 17 81665461 81665584 124 - 2.338 2.354 0.053
ENSG00000204237 E007 233.795743 0.0242736423 1.014311e-02 0.0587474352 17 81665585 81665997 413 - 2.366 2.134 -0.778
ENSG00000204237 E008 151.860515 0.0188365719 3.323101e-03 0.0253373571 17 81665998 81666145 148 - 2.202 1.945 -0.861
ENSG00000204237 E009 76.012631 0.0224692422 2.879251e-01 0.5287002249 17 81666146 81666149 4 - 1.798 1.671 -0.427
ENSG00000204237 E010 77.580153 0.0112246168 9.104624e-02 0.2655870910 17 81666150 81666154 5 - 1.835 1.677 -0.534
ENSG00000204237 E011 224.694522 0.0003309474 9.257982e-01 0.9650661623 17 81666155 81666276 122 - 2.186 2.152 -0.114
ENSG00000204237 E012 239.506560 0.0005313718 2.500575e-02 0.1122386928 17 81666277 81666517 241 - 2.136 2.187 0.170
ENSG00000204237 E013 137.735327 0.0106587197 1.024128e-05 0.0002141614 17 81666518 81666635 118 - 1.633 1.964 1.119
ENSG00000204237 E014 6.357490 1.2167925788 8.468991e-01 0.9232380426 17 81666642 81666669 28 - 0.284 0.725 2.221