ENSG00000203761

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314835 ENSG00000203761 HEK293_OSMI2_6hA HEK293_TMG_6hB   unprocessed_pseudogene unprocessed_pseudogene 4.526353 5.886373 3.970367 1.947913 0.2699529 -0.5669263 0.6746658 1.0774934 0.7309467 0.22903921 0.2256284 -0.5535650 0.15563333 0.19810000 0.19040000 -0.00770000 9.722798e-01 1.579646e-19 TRUE TRUE
MSTRG.2338.11 ENSG00000203761 HEK293_OSMI2_6hA HEK293_TMG_6hB   unprocessed_pseudogene   4.526353 5.886373 3.970367 1.947913 0.2699529 -0.5669263 0.5106513 0.0000000 1.2626636 0.00000000 0.1410104 6.9917073 0.10155000 0.00000000 0.31626667 0.31626667 1.579646e-19 1.579646e-19 TRUE TRUE
MSTRG.2338.12 ENSG00000203761 HEK293_OSMI2_6hA HEK293_TMG_6hB   unprocessed_pseudogene   4.526353 5.886373 3.970367 1.947913 0.2699529 -0.5669263 0.3557979 0.9139033 0.0000000 0.91390326 0.0000000 -6.5296699 0.07312083 0.09383333 0.00000000 -0.09383333 8.852085e-01 1.579646e-19 TRUE TRUE
MSTRG.2338.14 ENSG00000203761 HEK293_OSMI2_6hA HEK293_TMG_6hB   unprocessed_pseudogene   4.526353 5.886373 3.970367 1.947913 0.2699529 -0.5669263 0.1395844 0.2834843 0.0000000 0.14749975 0.0000000 -4.8752114 0.03589583 0.07423333 0.00000000 -0.07423333 4.870614e-01 1.579646e-19 TRUE TRUE
MSTRG.2338.15 ENSG00000203761 HEK293_OSMI2_6hA HEK293_TMG_6hB   unprocessed_pseudogene   4.526353 5.886373 3.970367 1.947913 0.2699529 -0.5669263 0.8122605 1.4345525 0.1526916 0.16520753 0.1526916 -3.1504112 0.17307500 0.28383333 0.03393333 -0.24990000 1.321221e-01 1.579646e-19 TRUE TRUE
MSTRG.2338.3 ENSG00000203761 HEK293_OSMI2_6hA HEK293_TMG_6hB   unprocessed_pseudogene   4.526353 5.886373 3.970367 1.947913 0.2699529 -0.5669263 1.4061813 1.5609142 1.0925012 0.79058979 0.3298234 -0.5108242 0.30813750 0.24160000 0.27293333 0.03133333 9.762387e-01 1.579646e-19 TRUE TRUE
MSTRG.2338.5 ENSG00000203761 HEK293_OSMI2_6hA HEK293_TMG_6hB   unprocessed_pseudogene   4.526353 5.886373 3.970367 1.947913 0.2699529 -0.5669263 0.2999236 0.3540704 0.2466498 0.07471531 0.1250466 -0.5044166 0.07020000 0.06490000 0.06220000 -0.00270000 9.493075e-01 1.579646e-19 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000203761 E001 0.7119354 2.263318491 0.455810990   1 155744044 155744471 428 + 0.483 0.000 -14.588
ENSG00000203761 E002 0.1779838 0.760734978 0.315364120   1 155744472 155744721 250 + 0.170 0.000 -12.549
ENSG00000203761 E003 0.0000000       1 155744722 155744743 22 +      
ENSG00000203761 E004 0.0000000       1 155744744 155744761 18 +      
ENSG00000203761 E005 0.5339515 2.042766724 0.432337706   1 155744762 155744992 231 + 0.401 0.000 -14.211
ENSG00000203761 E006 0.8899192 2.419316357 0.471412370   1 155744993 155745016 24 + 0.552 0.000 -14.968
ENSG00000203761 E007 0.7119354 2.263318491 0.455810990   1 155745017 155745063 47 + 0.483 0.000 -14.638
ENSG00000203761 E008 3.9044255 2.425934057 0.752261419 0.86808120 1 155745064 155745828 765 + 1.058 0.165 -4.495
ENSG00000203761 E009 0.4873834 0.024441170 1.000000000   1 155745829 155745912 84 + 0.167 0.160 -0.078
ENSG00000203761 E010 0.1426347 0.032193457 0.252899716   1 155745913 155746004 92 + 0.167 0.000 -12.514
ENSG00000203761 E011 5.5826215 0.005268950 0.447702152 0.66404061 1 155746005 155746140 136 + 0.879 0.753 -0.493
ENSG00000203761 E012 9.5279827 0.017288120 0.667427008 0.81458631 1 155746141 155746618 478 + 1.033 0.969 -0.238
ENSG00000203761 E013 4.0083843 0.011953342 0.318549897 0.55840821 1 155746619 155746688 70 + 0.789 0.614 -0.731
ENSG00000203761 E014 9.0848414 0.004209230 0.208469263 0.44002779 1 155746796 155746871 76 + 1.088 0.920 -0.619
ENSG00000203761 E015 14.1863882 0.008233332 0.975473146 0.98955735 1 155746872 155746935 64 + 1.177 1.143 -0.121
ENSG00000203761 E016 10.1625563 0.023140751 0.836623653 0.91762636 1 155747129 155747183 55 + 1.069 0.990 -0.289
ENSG00000203761 E017 15.8025642 0.002980548 0.948951738 0.97664851 1 155747269 155747407 139 + 1.216 1.189 -0.098
ENSG00000203761 E018 36.8413902 0.076145154 0.784609699 0.88730470 1 155747563 155747680 118 + 1.598 1.527 -0.243
ENSG00000203761 E019 28.1208998 0.005308948 0.929383250 0.96672640 1 155747762 155747803 42 + 1.462 1.419 -0.148
ENSG00000203761 E020 37.0686570 0.008380954 0.755785171 0.87008070 1 155747804 155747896 93 + 1.592 1.534 -0.198
ENSG00000203761 E021 29.6053301 0.088958735 0.921232461 0.96286485 1 155747897 155747976 80 + 1.470 1.450 -0.072
ENSG00000203761 E022 16.2118216 0.058504516 0.843892411 0.92153987 1 155747977 155747979 3 + 1.172 1.219 0.167
ENSG00000203761 E023 26.6569246 0.004472730 0.235784323 0.47177700 1 155747980 155748013 34 + 1.361 1.433 0.248
ENSG00000203761 E024 43.4563017 0.001169360 0.004077157 0.02960218 1 155748014 155748127 114 + 1.517 1.656 0.473
ENSG00000203761 E025 56.6925671 0.139242572 0.377697864 0.61032996 1 155748128 155748399 272 + 1.692 1.748 0.192
ENSG00000203761 E026 52.5736977 0.020818147 0.046321212 0.17084544 1 155748400 155748531 132 + 1.630 1.731 0.341
ENSG00000203761 E027 27.4692681 0.039789765 0.753477355 0.86881124 1 155748606 155748647 42 + 1.408 1.432 0.085
ENSG00000203761 E028 44.3869975 0.108108161 0.487984076 0.69264538 1 155748648 155748788 141 + 1.661 1.609 -0.177
ENSG00000203761 E029 22.8599594 0.065383840 0.043147537 0.16293348 1 155749327 155749431 105 + 1.481 1.269 -0.737
ENSG00000203761 E030 8.0314135 0.007715793 0.490069814 0.69402854 1 155749522 155749631 110 + 0.996 0.885 -0.417
ENSG00000203761 E031 11.2421775 0.003389259 0.293372362 0.53407129 1 155749632 155749897 266 + 0.996 1.083 0.318
ENSG00000203761 E032 4.3736223 0.007789359 0.219173104 0.45241911 1 155749898 155749922 25 + 0.581 0.753 0.728
ENSG00000203761 E033 13.3892158 0.002921669 0.260393756 0.49935463 1 155749923 155750315 393 + 1.071 1.156 0.305