ENSG00000203667

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000391839 ENSG00000203667 HEK293_OSMI2_6hA HEK293_TMG_6hB COX20 protein_coding processed_transcript 8.413462 3.916836 10.14114 0.4981171 0.5196044 1.370203 1.7275389 0.4445763 3.050397 0.44457633 0.3957929 2.7511244 0.20000417 0.09976667 0.29953333 0.19976667 2.998602e-01 9.519299e-25   FALSE
ENST00000411948 ENSG00000203667 HEK293_OSMI2_6hA HEK293_TMG_6hB COX20 protein_coding protein_coding 8.413462 3.916836 10.14114 0.4981171 0.5196044 1.370203 3.1021691 0.0000000 4.706530 0.00000000 0.4032411 8.8815820 0.31999167 0.00000000 0.46260000 0.46260000 9.519299e-25 9.519299e-25 FALSE FALSE
ENST00000464757 ENSG00000203667 HEK293_OSMI2_6hA HEK293_TMG_6hB COX20 protein_coding retained_intron 8.413462 3.916836 10.14114 0.4981171 0.5196044 1.370203 0.3947207 0.3820384 0.536684 0.07201525 0.1078097 0.4797123 0.06450417 0.10660000 0.05216667 -0.05443333 5.079389e-01 9.519299e-25   FALSE
MSTRG.3414.1 ENSG00000203667 HEK293_OSMI2_6hA HEK293_TMG_6hB COX20 protein_coding   8.413462 3.916836 10.14114 0.4981171 0.5196044 1.370203 2.2024274 2.0835879 1.477471 0.38950485 0.3887578 -0.4931155 0.28755833 0.52593333 0.14933333 -0.37660000 2.150954e-03 9.519299e-25 FALSE FALSE
MSTRG.3414.2 ENSG00000203667 HEK293_OSMI2_6hA HEK293_TMG_6hB COX20 protein_coding   8.413462 3.916836 10.14114 0.4981171 0.5196044 1.370203 0.7613441 0.9401198 0.000000 0.52804993 0.0000000 -6.5700375 0.10530417 0.25263333 0.00000000 -0.25263333 1.793984e-01 9.519299e-25   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000203667 E001 0.2027342 0.7823976821 0.93160025   1 244835256 244835269 14 + 0.000 0.118 8.515
ENSG00000203667 E002 1.6601323 0.2745897632 0.07647310 0.23768537 1 244835270 244835333 64 + 0.130 0.570 2.955
ENSG00000203667 E003 16.1541023 0.2620553414 0.67790675 0.82141186 1 244835476 244835615 140 + 1.090 1.326 0.836
ENSG00000203667 E004 3.1678669 0.0081801911 0.07185270 0.22850948 1 244835616 244835655 40 + 0.491 0.713 0.992
ENSG00000203667 E005 1.5597669 0.0124982970 0.53629917 0.72650931 1 244835656 244835657 2 + 0.380 0.445 0.355
ENSG00000203667 E006 1.7024016 0.0118821937 0.76775767 0.87727644 1 244835658 244835658 1 + 0.439 0.445 0.033
ENSG00000203667 E007 62.2421192 0.0010165359 0.01763177 0.08775989 1 244835659 244835756 98 + 1.795 1.822 0.092
ENSG00000203667 E008 2.5854939 0.8665887954 0.27461694 0.51460294 1 244836485 244836520 36 + 0.715 0.346 -1.780
ENSG00000203667 E009 25.9387868 0.6229160054 0.71974905 0.84804756 1 244839747 244841943 2197 + 1.394 1.456 0.214
ENSG00000203667 E010 65.2106495 0.0010189843 0.54735538 0.73438232 1 244841944 244842058 115 + 1.856 1.803 -0.178
ENSG00000203667 E011 72.4750057 0.0011517942 0.04903088 0.17727648 1 244842195 244842198 4 + 1.874 1.877 0.009
ENSG00000203667 E012 107.1534557 0.0006523288 0.01654231 0.08378637 1 244842199 244842258 60 + 2.042 2.040 -0.006
ENSG00000203667 E013 212.2189130 0.3924250448 0.84264851 0.92091813 1 244843041 244845057 2017 + 2.429 2.219 -0.703