ENSG00000203485

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330634 ENSG00000203485 HEK293_OSMI2_6hA HEK293_TMG_6hB INF2 protein_coding protein_coding 29.93599 43.2033 16.29766 4.695405 1.123594 -1.405925 2.968199 4.151504 1.323195 0.8364573 0.07611602 -1.64221722 0.09783750 0.09406667 0.08233333 -0.01173333 0.88842568 0.006494289 FALSE TRUE
ENST00000398337 ENSG00000203485 HEK293_OSMI2_6hA HEK293_TMG_6hB INF2 protein_coding protein_coding 29.93599 43.2033 16.29766 4.695405 1.123594 -1.405925 8.193311 14.774892 3.531968 2.4881554 0.10523603 -2.06150054 0.25507083 0.33730000 0.21860000 -0.11870000 0.13904164 0.006494289 FALSE TRUE
ENST00000674631 ENSG00000203485 HEK293_OSMI2_6hA HEK293_TMG_6hB INF2 protein_coding protein_coding 29.93599 43.2033 16.29766 4.695405 1.123594 -1.405925 4.010338 6.497626 1.472162 0.7517945 0.15083747 -2.13442803 0.12255417 0.15016667 0.09006667 -0.06010000 0.02103583 0.006494289 FALSE TRUE
ENST00000675557 ENSG00000203485 HEK293_OSMI2_6hA HEK293_TMG_6hB INF2 protein_coding retained_intron 29.93599 43.2033 16.29766 4.695405 1.123594 -1.405925 2.041909 1.600415 1.836066 0.3928920 0.44023800 0.19702167 0.07923750 0.03996667 0.11020000 0.07023333 0.19873845 0.006494289 FALSE FALSE
ENST00000675771 ENSG00000203485 HEK293_OSMI2_6hA HEK293_TMG_6hB INF2 protein_coding nonsense_mediated_decay 29.93599 43.2033 16.29766 4.695405 1.123594 -1.405925 2.825957 3.392928 3.204579 1.7652208 0.24316935 -0.08214689 0.10299583 0.07093333 0.19720000 0.12626667 0.69408900 0.006494289 FALSE TRUE
ENST00000675797 ENSG00000203485 HEK293_OSMI2_6hA HEK293_TMG_6hB INF2 protein_coding nonsense_mediated_decay 29.93599 43.2033 16.29766 4.695405 1.123594 -1.405925 2.825336 2.692733 0.000000 1.4120253 0.00000000 -8.07827536 0.09348333 0.06776667 0.00000000 -0.06776667 0.40093660 0.006494289 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000203485 E001 0.1779838 0.0349450004 1.257281e-01   14 104681146 104681582 437 + 0.207 0.000 -12.159
ENSG00000203485 E002 0.0000000       14 104684063 104684932 870 +      
ENSG00000203485 E003 0.0000000       14 104688307 104688572 266 +      
ENSG00000203485 E004 0.5365243 0.0271396204 6.373953e-01   14 104689152 104689245 94 + 0.207 0.128 -0.839
ENSG00000203485 E005 0.1723744 0.0392866528 1.000000e+00   14 104689523 104689600 78 + 0.000 0.068 11.680
ENSG00000203485 E006 0.3447487 0.6095247465 1.000000e+00   14 104689601 104689605 5 + 0.000 0.130 11.585
ENSG00000203485 E007 0.6783511 0.0193874923 3.516832e-01   14 104689606 104689608 3 + 0.000 0.226 13.874
ENSG00000203485 E008 5.5538578 0.0633715644 5.760463e-03 0.0385460094 14 104689609 104689617 9 + 0.207 0.807 3.144
ENSG00000203485 E009 9.0340702 0.0037113496 1.281059e-04 0.0018371330 14 104689618 104689620 3 + 0.347 1.001 2.885
ENSG00000203485 E010 9.2368045 0.0037818398 1.033532e-04 0.0015376042 14 104689621 104689622 2 + 0.347 1.009 2.912
ENSG00000203485 E011 81.1416243 0.0055691659 1.422529e-04 0.0020077977 14 104689623 104689739 117 + 1.630 1.871 0.815
ENSG00000203485 E012 4.9907162 0.0148462840 3.412704e-01 0.5792225306 14 104695990 104696490 501 + 0.813 0.661 -0.619
ENSG00000203485 E013 0.1723744 0.0392866528 1.000000e+00   14 104699368 104699598 231 + 0.000 0.068 11.680
ENSG00000203485 E014 0.2922838 0.0264049564 3.534727e-01   14 104699599 104699803 205 + 0.207 0.068 -1.846
ENSG00000203485 E015 0.2922838 0.0264049564 3.534727e-01   14 104699804 104699826 23 + 0.207 0.068 -1.846
ENSG00000203485 E016 0.1614157 0.0349623494 1.257100e-01   14 104699827 104699834 8 + 0.207 0.000 -14.665
ENSG00000203485 E017 0.2027342 0.0397149790 1.000000e+00   14 104700678 104700709 32 + 0.000 0.068 11.678
ENSG00000203485 E018 0.2027342 0.0397149790 1.000000e+00   14 104700737 104700864 128 + 0.000 0.068 11.678
ENSG00000203485 E019 59.3022823 0.0006901034 6.604747e-03 0.0427241791 14 104701357 104701365 9 + 1.569 1.726 0.535
ENSG00000203485 E020 254.9484106 0.0002388169 1.362701e-03 0.0126312982 14 104701366 104701756 391 + 2.257 2.343 0.287
ENSG00000203485 E021 11.4260956 0.0030243528 7.281975e-02 0.2304468251 14 104702512 104703104 593 + 1.160 0.963 -0.718
ENSG00000203485 E022 170.1942536 0.0002610652 4.858741e-02 0.1763541899 14 104703105 104703220 116 + 2.202 2.137 -0.218
ENSG00000203485 E023 99.5522540 0.0010462022 6.178626e-02 0.2068458953 14 104703295 104703305 11 + 1.986 1.905 -0.275
ENSG00000203485 E024 203.4145589 0.0005779330 1.800813e-02 0.0890563293 14 104703306 104703454 149 + 2.287 2.213 -0.247
ENSG00000203485 E025 104.9285281 0.0004342834 1.076022e-01 0.2950345589 14 104703916 104703949 34 + 1.997 1.930 -0.227
ENSG00000203485 E026 228.8418637 0.0011548500 1.464133e-04 0.0020557539 14 104703950 104704809 860 + 2.180 2.303 0.412
ENSG00000203485 E027 97.9474921 0.0005371680 3.635491e-02 0.1452067322 14 104706035 104706152 118 + 1.986 1.897 -0.301
ENSG00000203485 E028 39.8380649 0.0008900629 1.455560e-01 0.3557268888 14 104706153 104706176 24 + 1.455 1.553 0.336
ENSG00000203485 E029 2.2281479 0.6889256023 9.452481e-01 0.9748965820 14 104706600 104706697 98 + 0.554 0.419 -0.670
ENSG00000203485 E030 85.1245235 0.0004808133 1.234784e-01 0.3212514571 14 104706910 104707051 142 + 1.797 1.867 0.236
ENSG00000203485 E031 119.1540814 0.0004620457 6.860495e-01 0.8265379607 14 104707253 104707847 595 + 1.986 1.999 0.042
ENSG00000203485 E032 30.6818131 0.0013576624 3.428286e-01 0.5805125405 14 104707848 104707863 16 + 1.362 1.432 0.244
ENSG00000203485 E033 87.0230912 0.0038040031 3.440900e-01 0.5816797976 14 104707864 104708002 139 + 1.908 1.853 -0.185
ENSG00000203485 E034 0.4812263 0.0217681645 6.311815e-01   14 104708291 104708435 145 + 0.207 0.127 -0.846
ENSG00000203485 E035 106.9646809 0.0017258004 2.303800e-01 0.4655351228 14 104708436 104708531 96 + 1.995 1.937 -0.194
ENSG00000203485 E036 93.9624591 0.0092955069 2.309253e-01 0.4662295108 14 104708532 104708587 56 + 1.956 1.873 -0.277
ENSG00000203485 E037 9.6558007 0.2852340552 1.325354e-01 0.3358018250 14 104708588 104708670 83 + 1.200 0.850 -1.288
ENSG00000203485 E038 98.5583382 0.0022234214 7.228246e-05 0.0011401843 14 104708671 104708732 62 + 2.052 1.870 -0.612
ENSG00000203485 E039 72.7251448 0.0065606250 5.811342e-05 0.0009482125 14 104709281 104709293 13 + 1.964 1.722 -0.815
ENSG00000203485 E040 127.4448498 0.0004011756 7.668965e-04 0.0080017609 14 104709294 104709383 90 + 2.122 1.998 -0.416
ENSG00000203485 E041 107.8075918 0.0004530979 2.072076e-02 0.0984021763 14 104709620 104709705 86 + 2.031 1.937 -0.314
ENSG00000203485 E042 84.4477045 0.0012955437 8.124815e-01 0.9036859963 14 104710088 104710188 101 + 1.864 1.851 -0.043
ENSG00000203485 E043 2.2259190 0.1031842978 9.732616e-01 0.9885705807 14 104710725 104710881 157 + 0.452 0.457 0.030
ENSG00000203485 E044 1.6489860 0.0129036112 3.260181e-01 0.5652453231 14 104710882 104710918 37 + 0.207 0.404 1.328
ENSG00000203485 E045 1.5181179 0.0310505553 4.044338e-01 0.6318583571 14 104710919 104710936 18 + 0.207 0.374 1.162
ENSG00000203485 E046 70.2983732 0.0031027306 7.442910e-01 0.8632120544 14 104710937 104710989 53 + 1.762 1.779 0.057
ENSG00000203485 E047 59.8607160 0.0012607798 4.380763e-01 0.6572789755 14 104710990 104711007 18 + 1.743 1.698 -0.153
ENSG00000203485 E048 5.7863537 0.1087692673 1.090033e-02 0.0619457995 14 104711008 104711011 4 + 1.079 0.598 -1.890
ENSG00000203485 E049 9.6155527 0.1214053114 2.254355e-03 0.0187621311 14 104711012 104711078 67 + 1.312 0.754 -2.061
ENSG00000203485 E050 55.9616556 0.0022589915 3.477115e-01 0.5851632522 14 104711079 104711083 5 + 1.723 1.664 -0.200
ENSG00000203485 E051 114.4622939 0.0003907932 3.365787e-01 0.5749890618 14 104711084 104711186 103 + 2.013 1.973 -0.135
ENSG00000203485 E052 106.0160497 0.0004232608 6.300087e-01 0.7904264387 14 104711629 104711699 71 + 1.967 1.944 -0.076
ENSG00000203485 E053 157.2541189 0.0006901061 8.580748e-02 0.2560734440 14 104712433 104712553 121 + 2.071 2.128 0.193
ENSG00000203485 E054 0.4576437 0.1983803068 1.455450e-01   14 104712713 104712827 115 + 0.344 0.069 -2.817
ENSG00000203485 E055 82.4884358 0.0005230289 1.368964e-01 0.3427666744 14 104712828 104712832 5 + 1.784 1.853 0.231
ENSG00000203485 E056 208.2921489 0.0005395236 5.385536e-01 0.7280127181 14 104712833 104712992 160 + 2.226 2.241 0.049
ENSG00000203485 E057 2.7676278 0.1070363342 3.906131e-01 0.6208966421 14 104713202 104713206 5 + 0.664 0.463 -0.924
ENSG00000203485 E058 157.8435551 0.0012311434 5.035195e-01 0.7032475083 14 104713207 104713304 98 + 2.101 2.121 0.068
ENSG00000203485 E059 66.0223002 0.0005915614 3.812795e-01 0.6132748816 14 104713305 104713309 5 + 1.709 1.752 0.147
ENSG00000203485 E060 64.1751392 0.0006961931 5.733942e-01 0.7525621740 14 104713445 104713448 4 + 1.709 1.736 0.093
ENSG00000203485 E061 159.4887436 0.0003371294 1.196488e-01 0.3152841029 14 104713449 104713606 158 + 2.082 2.133 0.170
ENSG00000203485 E062 1.8224987 0.0194911085 8.384442e-03 0.0510879063 14 104713821 104713933 113 + 0.722 0.267 -2.328
ENSG00000203485 E063 130.1516595 0.0004437963 2.653496e-02 0.1168783740 14 104714203 104714283 81 + 1.970 2.054 0.282
ENSG00000203485 E064 138.4087740 0.0011683786 1.409278e-01 0.3489200318 14 104714284 104714395 112 + 2.021 2.077 0.190
ENSG00000203485 E065 142.0896103 0.0003113621 9.179038e-01 0.9611437899 14 104714396 104714507 112 + 2.073 2.074 0.003
ENSG00000203485 E066 151.8063262 0.0006940091 5.645998e-01 0.7464969900 14 104714508 104714588 81 + 2.120 2.096 -0.079
ENSG00000203485 E067 262.3435667 0.0004505865 6.547432e-01 0.8065636578 14 104714589 104714856 268 + 2.332 2.342 0.031
ENSG00000203485 E068 38.3052511 0.0084345177 9.558729e-01 0.9798425908 14 104714857 104715280 424 + 1.516 1.514 -0.005
ENSG00000203485 E069 3.9160792 0.0183115572 4.945586e-02 0.1783134759 14 104715281 104715283 3 + 0.852 0.549 -1.269
ENSG00000203485 E070 26.7298046 0.0107913088 5.878687e-02 0.2000353132 14 104715284 104715340 57 + 1.211 1.402 0.666
ENSG00000203485 E071 8.1341010 0.1380012393 2.828726e-02 0.1221261428 14 104715725 104715832 108 + 1.174 0.755 -1.574
ENSG00000203485 E072 12.0688525 0.1659064360 4.166074e-02 0.1590376998 14 104715833 104716017 185 + 1.329 0.911 -1.509
ENSG00000203485 E073 3.2969423 0.1555912471 5.087554e-01 0.7069953098 14 104717548 104717562 15 + 0.668 0.534 -0.596
ENSG00000203485 E074 7.2214885 0.1397067690 4.668494e-01 0.6779057664 14 104717563 104717646 84 + 0.951 0.798 -0.584
ENSG00000203485 E075 363.1685894 0.0010579633 2.231157e-03 0.0185964635 14 104718795 104722535 3741 + 2.415 2.494 0.263