ENSG00000198933

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361722 ENSG00000198933 HEK293_OSMI2_6hA HEK293_TMG_6hB TBKBP1 protein_coding protein_coding 11.22197 16.53993 6.960658 1.727283 0.5247383 -1.247459 2.0204270 2.9363197 1.0715565 0.79615852 0.22325606 -1.445805 0.18522083 0.18346667 0.158400000 -0.025066667 9.763419e-01 1.277956e-07 FALSE TRUE
ENST00000537587 ENSG00000198933 HEK293_OSMI2_6hA HEK293_TMG_6hB TBKBP1 protein_coding protein_coding 11.22197 16.53993 6.960658 1.727283 0.5247383 -1.247459 0.9240509 0.0000000 2.5397817 0.00000000 0.96697088 7.994230 0.11111667 0.00000000 0.352533333 0.352533333 1.277956e-07 1.277956e-07 FALSE FALSE
ENST00000578982 ENSG00000198933 HEK293_OSMI2_6hA HEK293_TMG_6hB TBKBP1 protein_coding protein_coding 11.22197 16.53993 6.960658 1.727283 0.5247383 -1.247459 3.1932639 6.1033133 1.5512381 1.67173986 0.08689437 -1.969264 0.26679583 0.35986667 0.223600000 -0.136266667 6.218488e-01 1.277956e-07 FALSE TRUE
ENST00000622396 ENSG00000198933 HEK293_OSMI2_6hA HEK293_TMG_6hB TBKBP1 protein_coding protein_coding 11.22197 16.53993 6.960658 1.727283 0.5247383 -1.247459 3.3945572 5.3844599 1.4945596 0.37620816 0.46603798 -1.842137 0.29203333 0.32943333 0.217833333 -0.111600000 6.723096e-01 1.277956e-07 FALSE TRUE
MSTRG.14554.1 ENSG00000198933 HEK293_OSMI2_6hA HEK293_TMG_6hB TBKBP1 protein_coding   11.22197 16.53993 6.960658 1.727283 0.5247383 -1.247459 0.6696678 0.5652698 0.0368065 0.04218778 0.03680650 -3.619458 0.05501667 0.03503333 0.006133333 -0.028900000 9.137885e-02 1.277956e-07 FALSE TRUE
MSTRG.14554.3 ENSG00000198933 HEK293_OSMI2_6hA HEK293_TMG_6hB TBKBP1 protein_coding   11.22197 16.53993 6.960658 1.727283 0.5247383 -1.247459 0.6065090 0.7198891 0.2667158 0.10158632 0.11909127 -1.399272 0.05629583 0.04573333 0.041466667 -0.004266667 9.481244e-01 1.277956e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198933 E001 2.064936 0.010103774 8.078204e-01 9.009019e-01 17 47694063 47694103 41 + 0.368 0.434 0.362
ENSG00000198933 E002 15.052264 0.068207804 3.063286e-01 5.469916e-01 17 47694161 47694194 34 + 0.949 1.135 0.678
ENSG00000198933 E003 10.788848 0.032389504 8.929950e-01 9.481398e-01 17 47694508 47694558 51 + 0.983 0.979 -0.013
ENSG00000198933 E004 15.132600 0.039656448 8.526434e-01 9.265227e-01 17 47694559 47694618 60 + 1.086 1.118 0.114
ENSG00000198933 E005 14.038919 0.023777716 8.734950e-01 9.378725e-01 17 47694619 47694663 45 + 1.089 1.081 -0.027
ENSG00000198933 E006 49.107208 0.236172821 7.163595e-01 8.458496e-01 17 47695264 47695684 421 + 1.600 1.593 -0.023
ENSG00000198933 E007 56.941877 0.207990130 4.365400e-01 6.561469e-01 17 47695685 47696078 394 + 1.576 1.673 0.331
ENSG00000198933 E008 111.321601 0.451892794 4.584642e-01 6.720914e-01 17 47696079 47696337 259 + 1.920 1.948 0.092
ENSG00000198933 E009 100.677844 0.004596263 3.113161e-03 2.409259e-02 17 47696711 47696833 123 + 1.996 1.878 -0.395
ENSG00000198933 E010 94.911809 0.067182932 8.474651e-02 2.542336e-01 17 47697089 47697193 105 + 1.992 1.843 -0.503
ENSG00000198933 E011 75.725035 0.113370183 3.298959e-01 5.688631e-01 17 47698595 47698691 97 + 1.855 1.758 -0.325
ENSG00000198933 E012 62.870920 0.078621934 2.669613e-01 5.065506e-01 17 47698692 47698775 84 + 1.769 1.682 -0.295
ENSG00000198933 E013 26.818207 0.038128993 3.017182e-01 5.422657e-01 17 47699320 47699322 3 + 1.401 1.327 -0.256
ENSG00000198933 E014 80.760936 0.048185414 1.555739e-01 3.702462e-01 17 47699323 47699495 173 + 1.883 1.785 -0.331
ENSG00000198933 E015 48.429272 0.035767405 2.246678e-02 1.041232e-01 17 47699636 47699697 62 + 1.734 1.545 -0.643
ENSG00000198933 E016 35.809609 0.076841595 1.694817e-01 3.898718e-01 17 47708394 47708512 119 + 1.581 1.427 -0.529
ENSG00000198933 E017 70.311431 0.003132680 5.206603e-07 1.603847e-05 17 47708725 47709413 689 + 1.431 1.802 1.264
ENSG00000198933 E018 41.004445 0.052309054 1.163196e-01 3.096539e-01 17 47709414 47709452 39 + 1.352 1.553 0.690
ENSG00000198933 E019 486.141602 1.216967403 3.935748e-01 6.232044e-01 17 47710498 47712052 1555 + 2.432 2.606 0.581