ENSG00000198876

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361264 ENSG00000198876 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF12 protein_coding protein_coding 45.18165 35.31475 46.99137 7.041033 2.822916 0.4120234 41.544098 34.7752258 42.246713 6.7237176 1.8601525 0.2807059 0.9267167 0.987266667 0.90086667 -0.0864 9.974048e-03 3.671218e-06 FALSE TRUE
MSTRG.32564.2 ENSG00000198876 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF12 protein_coding   45.18165 35.31475 46.99137 7.041033 2.822916 0.4120234 3.004622 0.0634851 4.235299 0.0634851 0.8894388 5.8522706 0.0598125 0.001366667 0.08836667 0.0870 3.671218e-06 3.671218e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198876 E001 1580.5046431 7.743522e-05 2.711146e-11 2.164621e-09 9 34086387 34088040 1654 - 3.163 3.219 0.184
ENSG00000198876 E002 695.5067015 2.288244e-04 1.827139e-03 1.589194e-02 9 34088041 34088508 468 - 2.812 2.857 0.150
ENSG00000198876 E003 501.5892703 7.751824e-04 7.481896e-01 8.656078e-01 9 34089412 34089590 179 - 2.695 2.694 -0.003
ENSG00000198876 E004 483.2961063 3.163299e-04 7.186383e-05 1.134951e-03 9 34093286 34093448 163 - 2.709 2.641 -0.227
ENSG00000198876 E005 5.8533615 5.255330e-02 8.949748e-01 9.491949e-01 9 34093449 34093779 331 - 0.816 0.836 0.079
ENSG00000198876 E006 289.5320256 3.769162e-04 4.775534e-02 1.744376e-01 9 34096716 34096781 66 - 2.477 2.432 -0.151
ENSG00000198876 E007 303.3289066 2.263225e-04 2.832109e-03 2.238468e-02 9 34098324 34098383 60 - 2.507 2.442 -0.215
ENSG00000198876 E008 377.0129189 4.732662e-04 6.608305e-05 1.057024e-03 9 34098384 34098487 104 - 2.609 2.527 -0.274
ENSG00000198876 E009 256.0444398 1.443920e-03 2.420824e-01 4.789068e-01 9 34098488 34098517 30 - 2.417 2.390 -0.090
ENSG00000198876 E010 294.2642927 1.584814e-03 2.211057e-01 4.548172e-01 9 34106434 34106494 61 - 2.478 2.451 -0.087
ENSG00000198876 E011 157.4979114 1.423513e-03 5.401276e-02 1.890987e-01 9 34107359 34107360 2 - 2.223 2.162 -0.204
ENSG00000198876 E012 477.4365976 3.974556e-04 4.647963e-02 1.712252e-01 9 34107361 34107565 205 - 2.690 2.655 -0.116
ENSG00000198876 E013 363.6484527 7.423812e-04 6.470488e-01 8.014979e-01 9 34125023 34125277 255 - 2.560 2.550 -0.032
ENSG00000198876 E014 0.6897577 3.589640e-02 3.622087e-01   9 34125482 34125604 123 - 0.285 0.126 -1.455
ENSG00000198876 E015 0.1614157 3.339298e-02 5.427415e-01   9 34125605 34125727 123 - 0.117 0.000 -10.102
ENSG00000198876 E016 0.4466850 2.318578e-02 1.035711e-01   9 34125882 34125939 58 - 0.284 0.000 -12.040
ENSG00000198876 E017 229.7022671 4.341064e-03 9.233958e-04 9.287719e-03 9 34126354 34126702 349 - 2.290 2.424 0.448
ENSG00000198876 E018 0.0000000       9 34127254 34127399 146 -