ENSG00000198836

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361828 ENSG00000198836 HEK293_OSMI2_6hA HEK293_TMG_6hB OPA1 protein_coding protein_coding 18.94341 4.749431 35.24899 1.406825 1.31538 2.88913 1.1251513 0.1018693 0.9584571 0.1018693 0.64865042 3.1138740 0.09881250 0.04496667 0.02670000 -0.01826667 9.209543e-01 1.27009e-10 FALSE TRUE
ENST00000361908 ENSG00000198836 HEK293_OSMI2_6hA HEK293_TMG_6hB OPA1 protein_coding protein_coding 18.94341 4.749431 35.24899 1.406825 1.31538 2.88913 3.4178660 1.1362228 6.2862948 0.3230004 0.05340762 2.4576156 0.18797917 0.23946667 0.17876667 -0.06070000 5.087848e-01 1.27009e-10 FALSE TRUE
ENST00000392436 ENSG00000198836 HEK293_OSMI2_6hA HEK293_TMG_6hB OPA1 protein_coding protein_coding 18.94341 4.749431 35.24899 1.406825 1.31538 2.88913 4.2481703 0.9015957 8.9944915 0.1737861 0.35428729 3.3041787 0.16869583 0.22686667 0.25593333 0.02906667 9.021677e-01 1.27009e-10 FALSE TRUE
ENST00000475899 ENSG00000198836 HEK293_OSMI2_6hA HEK293_TMG_6hB OPA1 protein_coding retained_intron 18.94341 4.749431 35.24899 1.406825 1.31538 2.88913 1.7645518 0.0000000 3.9904109 0.0000000 0.13644189 8.6440044 0.05505000 0.00000000 0.11353333 0.11353333 1.270090e-10 1.27009e-10 FALSE TRUE
ENST00000482865 ENSG00000198836 HEK293_OSMI2_6hA HEK293_TMG_6hB OPA1 protein_coding retained_intron 18.94341 4.749431 35.24899 1.406825 1.31538 2.88913 4.5037626 0.6753133 8.5011123 0.6753133 0.72302055 3.6345122 0.22203333 0.09463333 0.24033333 0.14570000 3.693806e-01 1.27009e-10 FALSE FALSE
ENST00000644959 ENSG00000198836 HEK293_OSMI2_6hA HEK293_TMG_6hB OPA1 protein_coding nonsense_mediated_decay 18.94341 4.749431 35.24899 1.406825 1.31538 2.88913 0.1682979 0.2452160 0.3574538 0.1369625 0.16947044 0.5258441 0.01680833 0.07113333 0.01006667 -0.06106667 6.717204e-01 1.27009e-10 TRUE TRUE
ENST00000646544 ENSG00000198836 HEK293_OSMI2_6hA HEK293_TMG_6hB OPA1 protein_coding protein_coding 18.94341 4.749431 35.24899 1.406825 1.31538 2.88913 0.1988384 0.2533370 0.0000000 0.2533370 0.00000000 -4.7188382 0.04818333 0.05226667 0.00000000 -0.05226667 6.423757e-01 1.27009e-10 FALSE TRUE
ENST00000646793 ENSG00000198836 HEK293_OSMI2_6hA HEK293_TMG_6hB OPA1 protein_coding protein_coding 18.94341 4.749431 35.24899 1.406825 1.31538 2.88913 0.2521162 0.3856457 0.5926649 0.3856457 0.23858391 0.6071470 0.02769167 0.07960000 0.01686667 -0.06273333 9.207521e-01 1.27009e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198836 E001 3.9608980 0.0180653475 0.8677643656 0.934727591 3 193593144 193593185 42 + 0.609 0.585 -0.105
ENSG00000198836 E002 7.9110250 0.0596753143 0.4661715275 0.677384871 3 193593186 193593207 22 + 0.868 0.724 -0.571
ENSG00000198836 E003 7.8697065 0.0976045136 0.3173290832 0.557308369 3 193593208 193593215 8 + 0.876 0.660 -0.868
ENSG00000198836 E004 7.9298060 0.0272673388 0.3792913506 0.611628147 3 193593216 193593216 1 + 0.870 0.723 -0.581
ENSG00000198836 E005 8.0606742 0.0144281313 0.5196647606 0.714783864 3 193593217 193593217 1 + 0.870 0.777 -0.365
ENSG00000198836 E006 8.0606742 0.0144281313 0.5196647606 0.714783864 3 193593218 193593219 2 + 0.870 0.777 -0.365
ENSG00000198836 E007 8.5946257 0.0142805196 0.4131142683 0.638463679 3 193593220 193593221 2 + 0.896 0.777 -0.462
ENSG00000198836 E008 10.0407282 0.0073038634 0.1788657564 0.402443782 3 193593222 193593227 6 + 0.963 0.777 -0.716
ENSG00000198836 E009 16.9712999 0.1241907986 0.5422218732 0.730645765 3 193593228 193593246 19 + 1.162 1.038 -0.447
ENSG00000198836 E010 22.0960861 0.0219747273 0.8910385718 0.947175912 3 193593247 193593279 33 + 1.252 1.239 -0.044
ENSG00000198836 E011 19.1410051 0.0138532149 0.8086405515 0.901376083 3 193593280 193593280 1 + 1.186 1.221 0.125
ENSG00000198836 E012 20.3915601 0.0087613723 0.5838286540 0.759496260 3 193593281 193593286 6 + 1.206 1.273 0.238
ENSG00000198836 E013 20.3562109 0.0083975476 0.5804509773 0.757472675 3 193593287 193593291 5 + 1.206 1.273 0.239
ENSG00000198836 E014 43.5187491 0.0012550555 0.3752625530 0.608389699 3 193593292 193593409 118 + 1.521 1.595 0.254
ENSG00000198836 E015 0.0000000       3 193596800 193596946 147 +      
ENSG00000198836 E016 0.8981716 0.0172671820 1.0000000000   3 193603500 193603557 58 + 0.238 0.233 -0.040
ENSG00000198836 E017 0.1426347 0.0327750494 1.0000000000   3 193614722 193614722 1 + 0.059 0.000 -8.877
ENSG00000198836 E018 38.1841253 0.0069111487 0.8801864821 0.941336749 3 193614723 193614761 39 + 1.476 1.478 0.007
ENSG00000198836 E019 136.1664940 0.0119524187 0.1728877989 0.394331211 3 193614762 193615030 269 + 2.033 1.948 -0.283
ENSG00000198836 E020 55.8679508 0.0007104444 0.0619200825 0.207119501 3 193615031 193615041 11 + 1.659 1.554 -0.357
ENSG00000198836 E021 63.5068645 0.0023559007 0.2198119060 0.453272722 3 193615674 193615702 29 + 1.708 1.646 -0.211
ENSG00000198836 E022 81.6710914 0.0108302238 0.1010806146 0.283737140 3 193615703 193615770 68 + 1.820 1.708 -0.378
ENSG00000198836 E023 81.4557467 0.0463618513 0.7109387484 0.842424493 3 193617178 193617285 108 + 1.810 1.749 -0.204
ENSG00000198836 E024 10.7831857 0.0965368786 0.7913312299 0.891213781 3 193617784 193617837 54 + 0.978 0.934 -0.164
ENSG00000198836 E025 0.1426347 0.0327750494 1.0000000000   3 193618703 193618826 124 + 0.059 0.000 -8.877
ENSG00000198836 E026 0.1426347 0.0327750494 1.0000000000   3 193618827 193618868 42 + 0.059 0.000 -8.877
ENSG00000198836 E027 69.7375533 0.1377227822 0.3731541117 0.606645134 3 193618869 193618936 68 + 1.714 1.811 0.329
ENSG00000198836 E028 0.0000000       3 193618937 193618937 1 +      
ENSG00000198836 E029 0.0000000       3 193626058 193626091 34 +      
ENSG00000198836 E030 35.6083505 0.0013834288 0.3119191398 0.552287122 3 193626092 193626202 111 + 1.439 1.527 0.305
ENSG00000198836 E031 1.4391377 0.0661905006 0.7714882887 0.879493956 3 193628509 193628616 108 + 0.308 0.382 0.451
ENSG00000198836 E032 68.7012499 0.0021996620 0.1631823304 0.381457341 3 193631612 193631665 54 + 1.712 1.803 0.308
ENSG00000198836 E033 0.1779838 0.0397652016 1.0000000000   3 193631755 193631769 15 + 0.059 0.000 -8.881
ENSG00000198836 E034 85.6823073 0.0087292521 0.5157293011 0.712083394 3 193635418 193635522 105 + 1.814 1.864 0.166
ENSG00000198836 E035 43.7491341 0.0165526522 0.7418850580 0.861587963 3 193637195 193637215 21 + 1.532 1.569 0.127
ENSG00000198836 E036 78.2607560 0.0019129017 0.5573296694 0.741361483 3 193637216 193637281 66 + 1.777 1.822 0.152
ENSG00000198836 E037 92.4428986 0.0008651496 0.4469456722 0.663396473 3 193637952 193638018 67 + 1.859 1.836 -0.079
ENSG00000198836 E038 80.7822856 0.0027442736 0.0785355542 0.241860283 3 193638019 193638065 47 + 1.812 1.722 -0.303
ENSG00000198836 E039 93.0394189 0.0005787942 0.0056752136 0.038116537 3 193642765 193642845 81 + 1.874 1.746 -0.429
ENSG00000198836 E040 88.2751288 0.0014421269 0.0138172722 0.073603846 3 193642975 193643049 75 + 1.849 1.729 -0.405
ENSG00000198836 E041 89.2153439 0.0004608860 0.2124306833 0.444587597 3 193643373 193643444 72 + 1.846 1.799 -0.160
ENSG00000198836 E042 101.7692059 0.0006179569 0.0041397074 0.029938571 3 193643528 193643627 100 + 1.914 1.788 -0.423
ENSG00000198836 E043 1.5387182 0.4323769340 0.7269684044 0.852402114 3 193643952 193643974 23 + 0.314 0.389 0.451
ENSG00000198836 E044 109.0121236 0.0005148438 0.0002492868 0.003212279 3 193643975 193644105 131 + 1.946 1.784 -0.547
ENSG00000198836 E045 0.2852693 0.2961238422 1.0000000000   3 193644106 193644151 46 + 0.110 0.000 -9.853
ENSG00000198836 E046 81.7384530 0.0009666276 0.0079925861 0.049273132 3 193645553 193645611 59 + 1.820 1.687 -0.449
ENSG00000198836 E047 61.7301768 0.0006766837 0.0103221631 0.059506440 3 193645612 193645625 14 + 1.701 1.555 -0.500
ENSG00000198836 E048 89.2503383 0.0005526246 0.0455156309 0.168845999 3 193645728 193645800 73 + 1.851 1.763 -0.296
ENSG00000198836 E049 0.0000000       3 193646485 193646579 95 +      
ENSG00000198836 E050 118.4389137 0.0019238139 0.0495316077 0.178488048 3 193647065 193647180 116 + 1.971 1.891 -0.271
ENSG00000198836 E051 99.9971862 0.0005443692 0.4318321524 0.652603665 3 193648070 193648134 65 + 1.889 1.867 -0.074
ENSG00000198836 E052 4.1640418 0.0066065723 0.0133523013 0.071859543 3 193648135 193648460 326 + 0.524 0.909 1.605
ENSG00000198836 E053 2.4764976 0.0175532131 0.1996286949 0.429182361 3 193648766 193648794 29 + 0.503 0.233 -1.620
ENSG00000198836 E054 99.6129217 0.0005602726 0.7192204844 0.847677260 3 193648795 193648871 77 + 1.884 1.883 -0.005
ENSG00000198836 E055 152.5381781 0.0047003010 0.8823118071 0.942506388 3 193654862 193655027 166 + 2.066 2.080 0.044
ENSG00000198836 E056 1.7614714 0.0891280310 0.4095494582 0.635737168 3 193655028 193655052 25 + 0.334 0.499 0.896
ENSG00000198836 E057 131.5356313 0.0035680173 0.6692833458 0.815776595 3 193657080 193657232 153 + 2.006 2.005 -0.002
ENSG00000198836 E058 111.7956081 0.0004311226 0.4138118889 0.638844181 3 193658887 193658995 109 + 1.939 1.918 -0.070
ENSG00000198836 E059 104.1623072 0.0003683069 0.0347658258 0.140988558 3 193659482 193659561 80 + 1.885 1.990 0.353
ENSG00000198836 E060 104.5310202 0.0005941696 0.0151904004 0.078809744 3 193662822 193662890 69 + 1.885 2.005 0.403
ENSG00000198836 E061 120.8389376 0.0004294195 0.0407419893 0.156643125 3 193662891 193662962 72 + 1.952 2.049 0.326
ENSG00000198836 E062 152.8059321 0.0003038833 0.0386420507 0.151221695 3 193664880 193664996 117 + 2.052 2.141 0.297
ENSG00000198836 E063 144.7134814 0.0003306692 0.0653174999 0.214607421 3 193666296 193666389 94 + 2.030 2.113 0.277
ENSG00000198836 E064 85.0180165 0.0004510039 0.1608048166 0.377975562 3 193667170 193667175 6 + 1.801 1.883 0.275
ENSG00000198836 E065 132.8712007 0.0005579076 0.4061916211 0.633188368 3 193667176 193667280 105 + 2.000 2.049 0.163
ENSG00000198836 E066 0.0000000       3 193667371 193667455 85 +      
ENSG00000198836 E067 0.3393995 0.0249959689 1.0000000000   3 193668315 193668333 19 + 0.112 0.000 -9.880
ENSG00000198836 E068 1.0997382 0.0373432029 0.5018037921   3 193668334 193668484 151 + 0.239 0.383 0.949
ENSG00000198836 E069 1.7787094 0.0113333867 0.0363972565 0.145319322 3 193668485 193668931 447 + 0.274 0.659 2.018
ENSG00000198836 E070 0.1426347 0.0327750494 1.0000000000   3 193689069 193689170 102 + 0.059 0.000 -8.877
ENSG00000198836 E071 0.0000000       3 193691394 193692062 669 +      
ENSG00000198836 E072 78.2170345 0.0005273206 0.1044891598 0.289752729 3 193692063 193692132 70 + 1.763 1.858 0.322
ENSG00000198836 E073 502.2971956 0.0174431134 0.0701130229 0.225029716 3 193694606 193697811 3206 + 2.555 2.691 0.454