ENSG00000198732

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361956 ENSG00000198732 HEK293_OSMI2_6hA HEK293_TMG_6hB SMOC1 protein_coding protein_coding 25.16258 25.69449 20.41252 0.1024837 0.7207676 -0.3318599 12.9899180 14.352714 8.150770 0.3565928 0.7340155 -0.8155513 0.51430417 0.5585333 0.4019333 -0.1566000 2.079567e-01 5.705736e-24 FALSE TRUE
ENST00000381280 ENSG00000198732 HEK293_OSMI2_6hA HEK293_TMG_6hB SMOC1 protein_coding protein_coding 25.16258 25.69449 20.41252 0.1024837 0.7207676 -0.3318599 8.2627206 7.652330 9.357826 0.3622732 1.2339772 0.2899312 0.33005000 0.2977333 0.4555000 0.1577667 1.413946e-01 5.705736e-24 FALSE TRUE
MSTRG.9810.2 ENSG00000198732 HEK293_OSMI2_6hA HEK293_TMG_6hB SMOC1 protein_coding   25.16258 25.69449 20.41252 0.1024837 0.7207676 -0.3318599 3.1152132 3.574109 0.000000 0.4716654 0.0000000 -8.4854707 0.12212083 0.1392333 0.0000000 -0.1392333 1.697377e-17 5.705736e-24 FALSE TRUE
MSTRG.9810.5 ENSG00000198732 HEK293_OSMI2_6hA HEK293_TMG_6hB SMOC1 protein_coding   25.16258 25.69449 20.41252 0.1024837 0.7207676 -0.3318599 0.5945708 0.000000 2.903920 0.0000000 0.2541559 8.1868176 0.02500833 0.0000000 0.1425333 0.1425333 5.705736e-24 5.705736e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198732 E001 0.0000000       14 69854131 69854340 210 +      
ENSG00000198732 E002 0.0000000       14 69858506 69858646 141 +      
ENSG00000198732 E003 0.0000000       14 69864162 69864214 53 +      
ENSG00000198732 E004 1.1539680 0.0151554292 1.466720e-02   14 69879402 69879415 14 + 0.000 0.457 11.728
ENSG00000198732 E005 5.0419819 0.0059382229 2.658584e-04 3.384473e-03 14 69879416 69879425 10 + 0.337 0.914 2.617
ENSG00000198732 E006 16.5658027 0.0052750783 2.035295e-04 2.714094e-03 14 69879426 69879431 6 + 0.982 1.344 1.294
ENSG00000198732 E007 35.9508044 0.0017009287 1.938353e-03 1.665706e-02 14 69879432 69879494 63 + 1.428 1.626 0.677
ENSG00000198732 E008 116.6425100 0.0003815430 1.092775e-01 2.979264e-01 14 69879495 69879777 283 + 2.025 2.081 0.189
ENSG00000198732 E009 0.1308682 0.0313368346 6.872682e-01   14 69952137 69952137 1 + 0.000 0.102 10.491
ENSG00000198732 E010 199.9829911 0.0002941924 7.818027e-02 2.411746e-01 14 69952138 69952303 166 + 2.317 2.274 -0.144
ENSG00000198732 E011 225.4262920 0.0011896823 4.857294e-01 6.910860e-01 14 69953420 69953532 113 + 2.356 2.340 -0.052
ENSG00000198732 E012 110.5469507 0.0017101806 4.302739e-01 6.513037e-01 14 69975715 69975720 6 + 2.056 2.029 -0.090
ENSG00000198732 E013 227.8211961 0.0013802775 3.269829e-01 5.661163e-01 14 69975721 69975814 94 + 2.366 2.342 -0.080
ENSG00000198732 E014 210.6453657 0.0003264958 4.366411e-04 5.095637e-03 14 69977918 69977965 48 + 2.367 2.282 -0.285
ENSG00000198732 E015 0.6479912 0.0943010457 1.037581e-01   14 69977966 69978088 123 + 0.000 0.315 12.019
ENSG00000198732 E016 26.1989632 0.0019403715 1.080432e-01 2.957864e-01 14 69992384 69992416 33 + 1.488 1.378 -0.379
ENSG00000198732 E017 229.1128363 0.0002369973 1.039501e-04 1.544860e-03 14 69992417 69992473 57 + 2.404 2.314 -0.299
ENSG00000198732 E018 0.1308682 0.0313368346 6.872682e-01   14 69994239 69994399 161 + 0.000 0.102 10.491
ENSG00000198732 E019 242.2211444 0.0002175509 2.336898e-04 3.042464e-03 14 69994400 69994480 81 + 2.424 2.342 -0.274
ENSG00000198732 E020 326.1428333 0.0002817037 5.895163e-02 2.004072e-01 14 70010754 70010946 193 + 2.527 2.491 -0.121
ENSG00000198732 E021 261.1187897 0.0002584070 5.289073e-01 7.212307e-01 14 70011485 70011567 83 + 2.416 2.404 -0.041
ENSG00000198732 E022 0.5059767 0.0213213377 1.621393e-01   14 70011568 70011568 1 + 0.000 0.255 12.244
ENSG00000198732 E023 268.1254419 0.0002209919 2.323190e-01 4.679196e-01 14 70013386 70013491 106 + 2.435 2.411 -0.081
ENSG00000198732 E024 437.5098317 0.0013295110 3.773841e-01 6.101632e-01 14 70023203 70023447 245 + 2.644 2.626 -0.060
ENSG00000198732 E025 75.8756059 0.0006491437 8.562128e-01 9.283743e-01 14 70030242 70030244 3 + 1.868 1.878 0.033
ENSG00000198732 E026 1078.3747263 0.0002036385 6.104035e-17 1.203955e-14 14 70030245 70032366 2122 + 2.964 3.058 0.312