ENSG00000198689

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370695 ENSG00000198689 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC9A6 protein_coding protein_coding 8.327182 3.485243 13.15391 0.6857037 0.3052852 1.913123 4.5249713 2.3502597 4.08487868 0.6867863 0.73054594 0.7948751 0.54630833 0.64316667 0.310966667 -0.33220000 6.881731e-02 9.539342e-19 FALSE TRUE
ENST00000630721 ENSG00000198689 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC9A6 protein_coding protein_coding 8.327182 3.485243 13.15391 0.6857037 0.3052852 1.913123 0.0726618 0.3129419 0.00000000 0.2858539 0.00000000 -5.0132027 0.01297500 0.07453333 0.000000000 -0.07453333 2.777606e-01 9.539342e-19 FALSE TRUE
ENST00000636347 ENSG00000198689 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC9A6 protein_coding protein_coding 8.327182 3.485243 13.15391 0.6857037 0.3052852 1.913123 0.2919701 0.3440018 0.06601552 0.1347557 0.06601552 -2.2193908 0.05873750 0.11436667 0.004866667 -0.10950000 8.573076e-02 9.539342e-19 FALSE TRUE
ENST00000637195 ENSG00000198689 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC9A6 protein_coding protein_coding 8.327182 3.485243 13.15391 0.6857037 0.3052852 1.913123 0.1444998 0.1418639 0.08348457 0.1118210 0.04212946 -0.6999792 0.02679167 0.06056667 0.006433333 -0.05413333 7.706040e-01 9.539342e-19 FALSE TRUE
MSTRG.34952.8 ENSG00000198689 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC9A6 protein_coding   8.327182 3.485243 13.15391 0.6857037 0.3052852 1.913123 2.3158252 0.0000000 8.09277448 0.0000000 0.70064989 9.6622722 0.20435000 0.00000000 0.614733333 0.61473333 9.539342e-19 9.539342e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198689 E001 2.9139436 0.2923482581 2.577859e-04 3.301964e-03 X 135973841 135974032 192 + 0.127 1.039 4.874
ENSG00000198689 E002 0.3453689 0.0277457006 3.754567e-01   X 135974636 135974636 1 + 0.069 0.205 1.811
ENSG00000198689 E003 2.7129271 0.0326480512 9.967967e-08 3.696930e-06 X 135974637 135974763 127 + 0.128 1.002 4.716
ENSG00000198689 E004 0.8507255 0.1234042528 6.335813e-04   X 135974764 135974783 20 + 0.000 0.607 14.759
ENSG00000198689 E005 1.7002335 0.5768054223 1.339448e-01 3.380028e-01 X 135974784 135975082 299 + 0.179 0.737 3.123
ENSG00000198689 E006 1.1342298 0.0938367556 6.182603e-01   X 135975242 135975296 55 + 0.309 0.205 -0.775
ENSG00000198689 E007 0.0000000       X 135983467 135983722 256 +      
ENSG00000198689 E008 0.0000000       X 135983723 135983789 67 +      
ENSG00000198689 E009 0.0000000       X 135985135 135985426 292 +      
ENSG00000198689 E010 0.0000000       X 135985427 135985429 3 +      
ENSG00000198689 E011 0.3040503 0.0274424043 8.692556e-01   X 135985430 135985432 3 + 0.129 0.000 -12.587
ENSG00000198689 E012 0.3040503 0.0274424043 8.692556e-01   X 135985433 135985434 2 + 0.129 0.000 -12.587
ENSG00000198689 E013 3.9121531 0.0065096206 2.625331e-01 5.017316e-01 X 135985435 135985472 38 + 0.575 0.766 0.808
ENSG00000198689 E014 3.1260686 0.0076447091 7.178792e-02 2.283848e-01 X 135985473 135985477 5 + 0.462 0.766 1.348
ENSG00000198689 E015 11.6656998 0.0045614212 9.835738e-05 1.474779e-03 X 135985478 135985602 125 + 0.907 1.319 1.490
ENSG00000198689 E016 15.3972331 0.0022199135 4.025121e-03 2.930707e-02 X 135985603 135985623 21 + 1.061 1.345 1.005
ENSG00000198689 E017 32.9687279 0.0012917420 1.350489e-02 7.239145e-02 X 135985624 135985715 92 + 1.406 1.591 0.635
ENSG00000198689 E018 23.0694210 0.0019164292 4.370401e-01 6.564729e-01 X 135985716 135985717 2 + 1.285 1.368 0.290
ENSG00000198689 E019 43.2408731 0.0012058611 5.280070e-01 7.206347e-01 X 135985718 135985827 110 + 1.552 1.611 0.202
ENSG00000198689 E020 45.6305116 0.0011245109 7.604047e-01 8.727756e-01 X 135994786 135994889 104 + 1.590 1.592 0.004
ENSG00000198689 E021 42.6083727 0.0010785200 1.239594e-01 3.220014e-01 X 135994890 135994985 96 + 1.583 1.502 -0.275
ENSG00000198689 E022 34.4595227 0.0026608706 5.231075e-01 7.171512e-01 X 135998108 135998185 78 + 1.484 1.458 -0.087
ENSG00000198689 E023 41.6260902 0.0009924595 6.230519e-02 2.079520e-01 X 135998482 135998558 77 + 1.579 1.476 -0.351
ENSG00000198689 E024 53.9157869 0.0110562329 1.856612e-01 4.114034e-01 X 135998856 135998968 113 + 1.682 1.601 -0.274
ENSG00000198689 E025 0.8545700 0.3838578419 3.841463e-01   X 135998969 136000278 1310 + 0.276 0.000 -12.915
ENSG00000198689 E026 0.0000000       X 136000578 136000651 74 +      
ENSG00000198689 E027 58.0327919 0.0108707359 1.015024e-01 2.845166e-01 X 136002108 136002213 106 + 1.717 1.615 -0.346
ENSG00000198689 E028 0.0000000       X 136010120 136010297 178 +      
ENSG00000198689 E029 70.0611387 0.0055938508 7.996097e-03 4.928576e-02 X 136010442 136010583 142 + 1.804 1.659 -0.494
ENSG00000198689 E030 0.0000000       X 136010584 136010794 211 +      
ENSG00000198689 E031 62.8745861 0.0008795537 1.630324e-02 8.290159e-02 X 136012949 136013054 106 + 1.753 1.642 -0.376
ENSG00000198689 E032 53.2083759 0.0040667194 2.216581e-01 4.554851e-01 X 136013349 136013437 89 + 1.672 1.616 -0.192
ENSG00000198689 E033 52.1372269 0.0007692748 1.210512e-01 3.175458e-01 X 136016645 136016758 114 + 1.668 1.598 -0.238
ENSG00000198689 E034 67.5797188 0.0005538757 1.502858e-03 1.363936e-02 X 136022586 136022697 112 + 1.790 1.642 -0.504
ENSG00000198689 E035 73.1645543 0.0005321319 4.573982e-03 3.233567e-02 X 136024330 136024455 126 + 1.821 1.698 -0.416
ENSG00000198689 E036 36.2428638 0.0084662179 3.934097e-02 1.530795e-01 X 136024456 136024483 28 + 1.530 1.377 -0.524
ENSG00000198689 E037 0.4397201 0.0741034490 1.259934e-01   X 136028886 136028975 90 + 0.069 0.341 2.788
ENSG00000198689 E038 0.1779838 0.0362125111 1.000000e+00   X 136029342 136029442 101 + 0.069 0.000 -11.523
ENSG00000198689 E039 0.5061644 0.5319880333 2.164018e-01   X 136029443 136029893 451 + 0.069 0.349 2.832
ENSG00000198689 E040 0.0000000       X 136029894 136030131 238 +      
ENSG00000198689 E041 40.9346453 0.0168244527 2.618365e-01 5.009424e-01 X 136030132 136030162 31 + 1.569 1.488 -0.278
ENSG00000198689 E042 1.8518785 0.0127152488 4.329938e-01 6.534869e-01 X 136030163 136030460 298 + 0.377 0.532 0.803
ENSG00000198689 E043 0.9405353 0.0852167930 6.219554e-01   X 136033034 136033413 380 + 0.229 0.341 0.780
ENSG00000198689 E044 42.6492925 0.0013280259 1.107260e-01 3.001791e-01 X 136033414 136033475 62 + 1.586 1.502 -0.290
ENSG00000198689 E045 30.3351259 0.0013474982 1.664587e-01 3.858156e-01 X 136033476 136033493 18 + 1.443 1.356 -0.300
ENSG00000198689 E046 1.0901348 0.0151918450 1.161997e-01   X 136038041 136039181 1141 + 0.344 0.000 -14.448
ENSG00000198689 E047 0.6434498 0.0196360256 3.323976e-01   X 136039182 136040043 862 + 0.228 0.000 -13.639
ENSG00000198689 E048 0.1779838 0.0362125111 1.000000e+00   X 136040044 136040075 32 + 0.069 0.000 -11.523
ENSG00000198689 E049 56.5042869 0.0009507069 6.968797e-01 8.335420e-01 X 136040076 136040181 106 + 1.688 1.687 -0.004
ENSG00000198689 E050 559.7964676 0.0023177045 5.561635e-06 1.264551e-04 X 136044452 136047269 2818 + 2.642 2.756 0.377