ENSG00000198673

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000547075 ENSG00000198673 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFA2 protein_coding processed_transcript 1.401332 1.299426 1.001863 0.2112297 0.3674198 -0.3719211 0.34144002 0.300088344 0.33152455 0.078290307 0.166006770 0.139310 0.23047083 0.223966667 0.24236667 0.01840000 0.83254911 0.03230633   FALSE
ENST00000547941 ENSG00000198673 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFA2 protein_coding retained_intron 1.401332 1.299426 1.001863 0.2112297 0.3674198 -0.3719211 0.04940834 0.000000000 0.15748798 0.000000000 0.026118864 4.065986 0.05400417 0.000000000 0.26076667 0.26076667 0.03230633 0.03230633   FALSE
ENST00000548541 ENSG00000198673 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFA2 protein_coding processed_transcript 1.401332 1.299426 1.001863 0.2112297 0.3674198 -0.3719211 0.50848958 0.701098745 0.27151895 0.207763775 0.152475998 -1.336818 0.35043333 0.542100000 0.19743333 -0.34466667 0.45289272 0.03230633   FALSE
ENST00000550003 ENSG00000198673 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFA2 protein_coding protein_coding 1.401332 1.299426 1.001863 0.2112297 0.3674198 -0.3719211 0.02323578 0.006404949 0.08856827 0.006404949 0.007312704 2.586992 0.02811667 0.006533333 0.13940000 0.13286667 0.13794878 0.03230633   FALSE
ENST00000550060 ENSG00000198673 HEK293_OSMI2_6hA HEK293_TMG_6hB TAFA2 protein_coding processed_transcript 1.401332 1.299426 1.001863 0.2112297 0.3674198 -0.3719211 0.27638026 0.158445404 0.05350446 0.158445404 0.053504459 -1.407351 0.18289583 0.129766667 0.03973333 -0.09003333 1.00000000 0.03230633   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198673 E001 0.1426347 0.044228526 0.5367723238   12 61708273 61708273 1 - 0.121 0.000 -9.923
ENSG00000198673 E002 0.1426347 0.044228526 0.5367723238   12 61708274 61708276 3 - 0.121 0.000 -11.949
ENSG00000198673 E003 2.4891217 0.010281965 0.0001605592 0.002225122 12 61708277 61710122 1846 - 0.765 0.122 -3.900
ENSG00000198673 E004 0.8236465 0.160815305 0.0442123427   12 61710123 61710417 295 - 0.419 0.000 -13.654
ENSG00000198673 E005 0.0000000       12 61720687 61720924 238 -      
ENSG00000198673 E006 0.5421338 0.028782779 0.6259055650   12 61753622 61753677 56 - 0.216 0.122 -0.992
ENSG00000198673 E007 0.5421338 0.028782779 0.6259055650   12 61753678 61753723 46 - 0.216 0.122 -0.992
ENSG00000198673 E008 0.5233527 0.029817654 0.6219575390   12 61753724 61753746 23 - 0.216 0.122 -0.990
ENSG00000198673 E009 0.6542209 0.024541227 0.9498034780   12 61754872 61755024 153 - 0.216 0.217 0.007
ENSG00000198673 E010 0.0000000       12 61827154 61827233 80 -      
ENSG00000198673 E011 0.1308682 0.033178845 0.4547829419   12 61867320 61867426 107 - 0.000 0.121 11.107
ENSG00000198673 E012 0.0000000       12 61878078 61878140 63 -      
ENSG00000198673 E013 0.0000000       12 61890342 61890423 82 -      
ENSG00000198673 E014 0.2922838 0.027442404 0.9611490741   12 62023652 62023779 128 - 0.121 0.121 0.004
ENSG00000198673 E015 0.0000000       12 62070422 62070562 141 -      
ENSG00000198673 E016 0.0000000       12 62104744 62104928 185 -      
ENSG00000198673 E017 0.0000000       12 62135805 62136036 232 -      
ENSG00000198673 E018 0.4952057 0.049084230 0.6406287632   12 62191259 62192773 1515 - 0.216 0.122 -0.992
ENSG00000198673 E019 0.0000000       12 62198212 62198406 195 -      
ENSG00000198673 E020 0.0000000       12 62206889 62207171 283 -      
ENSG00000198673 E021 0.0000000       12 62207172 62207250 79 -      
ENSG00000198673 E022 0.0000000       12 62242431 62242432 2 -      
ENSG00000198673 E023 0.0000000       12 62242433 62242570 138 -      
ENSG00000198673 E024 0.7796672 0.019861519 0.6003247903   12 62252100 62253401 1302 - 0.216 0.294 0.592
ENSG00000198673 E025 0.5649788 0.024441170 0.0336417958   12 62253491 62253682 192 - 0.000 0.359 12.768
ENSG00000198673 E026 1.7152132 0.011709117 0.8484160942 0.924040067 12 62255165 62255314 150 - 0.467 0.417 -0.258
ENSG00000198673 E027 0.5941213 0.063727269 0.3485805804   12 62258226 62258762 537 - 0.293 0.121 -1.582
ENSG00000198673 E028 2.8225134 0.008922993 0.8859842542 0.944510383 12 62258763 62258783 21 - 0.591 0.592 0.004
ENSG00000198673 E029 4.4020568 0.006668293 0.5484338974 0.735217143 12 62258784 62258842 59 - 0.789 0.688 -0.409
ENSG00000198673 E030 2.0828070 0.012068437 0.0781004492 0.241036103 12 62258843 62258910 68 - 0.359 0.626 1.324
ENSG00000198673 E031 0.5885118 0.038536831 0.9523207300   12 62258911 62259039 129 - 0.215 0.216 0.008
ENSG00000198673 E032 2.3741631 0.011185945 0.1457716390 0.356038734 12 62259479 62260009 531 - 0.416 0.626 1.006
ENSG00000198673 E033 0.1614157 0.034313828 0.5374537257   12 62260010 62260014 5 - 0.121 0.000 -11.952
ENSG00000198673 E034 5.0128956 0.006095305 0.0337765175 0.138267716 12 62260015 62260170 156 - 0.657 0.891 0.938
ENSG00000198673 E035 0.0000000       12 62267173 62267246 74 -      
ENSG00000198673 E036 0.0000000       12 62274140 62274301 162 -      
ENSG00000198673 E037 0.0000000       12 62277525 62277629 105 -      
ENSG00000198673 E038 0.0000000       12 62279106 62279150 45 -