ENSG00000198668

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356978 ENSG00000198668 HEK293_OSMI2_6hA HEK293_TMG_6hB CALM1 protein_coding protein_coding 122.3567 67.19999 167.8754 18.83565 7.094489 1.32073 50.54888 30.06680 59.314720 8.242730 4.117266 0.97998251 0.45078750 0.4515000 0.3528333 -0.09866667 0.741519367 0.006599825 FALSE TRUE
ENST00000553995 ENSG00000198668 HEK293_OSMI2_6hA HEK293_TMG_6hB CALM1 protein_coding retained_intron 122.3567 67.19999 167.8754 18.83565 7.094489 1.32073 13.87091 9.09930 8.573048 5.484126 3.410770 -0.08585014 0.09577917 0.1390333 0.0530000 -0.08603333 0.949222050 0.006599825 FALSE TRUE
ENST00000557020 ENSG00000198668 HEK293_OSMI2_6hA HEK293_TMG_6hB CALM1 protein_coding protein_coding 122.3567 67.19999 167.8754 18.83565 7.094489 1.32073 52.00491 24.54793 92.673105 8.355837 7.477406 1.91611716 0.39497500 0.3508000 0.5504000 0.19960000 0.006599825 0.006599825 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198668 E001 0.0000000       14 90396502 90396658 157 +      
ENSG00000198668 E002 0.6659874 0.0253792059 0.6209683787   14 90397029 90397031 3 + 0.237 0.155 -0.758
ENSG00000198668 E003 30.0659413 0.0059538686 0.0043348763 0.031017178 14 90397032 90397039 8 + 1.382 1.613 0.795
ENSG00000198668 E004 135.3813802 0.0268556658 0.0022563656 0.018777946 14 90397040 90397055 16 + 1.997 2.275 0.928
ENSG00000198668 E005 265.6106208 0.0147141553 0.0012066476 0.011481847 14 90397056 90397154 99 + 2.318 2.537 0.730
ENSG00000198668 E006 393.2044350 0.0027780482 0.0056390148 0.037933627 14 90397155 90397233 79 + 2.540 2.648 0.359
ENSG00000198668 E007 2.4529940 0.3009334319 0.3398539030 0.577812000 14 90397692 90397858 167 + 0.425 0.658 1.098
ENSG00000198668 E008 1.8844470 0.3842005227 0.6226464358 0.785602099 14 90397932 90398261 330 + 0.390 0.514 0.636
ENSG00000198668 E009 7.5887320 0.0774071539 0.3202146846 0.559912465 14 90398262 90398451 190 + 0.851 1.017 0.624
ENSG00000198668 E010 10.4852045 0.0658230335 0.4071774072 0.633874384 14 90398452 90398488 37 + 0.991 1.118 0.465
ENSG00000198668 E011 22.0758581 0.1049608661 0.4990861266 0.700161540 14 90398489 90398990 502 + 1.300 1.414 0.399
ENSG00000198668 E012 16.2070420 0.0094859444 0.1886058461 0.415195617 14 90398991 90399064 74 + 1.164 1.307 0.502
ENSG00000198668 E013 12.9296453 0.0158457837 0.2114369267 0.443480636 14 90399065 90399087 23 + 1.068 1.216 0.531
ENSG00000198668 E014 8.8931115 0.0132943615 0.4281180260 0.649542385 14 90399088 90399162 75 + 0.942 1.052 0.405
ENSG00000198668 E015 29.8258061 0.1200688245 0.8777019491 0.940083367 14 90399163 90399977 815 + 1.457 1.501 0.152
ENSG00000198668 E016 25.3029653 0.0242582788 0.7285957005 0.853373342 14 90399978 90400064 87 + 1.417 1.384 -0.114
ENSG00000198668 E017 453.6065065 0.0022154076 0.8069722135 0.900309704 14 90400065 90400095 31 + 2.634 2.664 0.101
ENSG00000198668 E018 6.0368440 0.0095164919 0.9572493961 0.980464435 14 90400096 90400431 336 + 0.819 0.846 0.105
ENSG00000198668 E019 721.3350976 0.0031413494 0.0554025277 0.192248130 14 90401259 90401332 74 + 2.856 2.825 -0.104
ENSG00000198668 E020 865.5616771 0.0029035570 0.0036958965 0.027446573 14 90401333 90401402 70 + 2.942 2.891 -0.170
ENSG00000198668 E021 6.0837402 0.0048112841 0.2337939218 0.469553730 14 90401403 90401613 211 + 0.892 0.757 -0.527
ENSG00000198668 E022 13.2857012 0.0701366956 0.9932461176 0.998295705 14 90403632 90403861 230 + 1.140 1.135 -0.016
ENSG00000198668 E023 1091.7268831 0.0017782540 0.0001182844 0.001718778 14 90403862 90403968 107 + 3.045 2.987 -0.191
ENSG00000198668 E024 5.5985655 0.0052458878 0.2862862966 0.526955819 14 90403969 90404153 185 + 0.849 0.724 -0.499
ENSG00000198668 E025 7.6416448 0.1216646858 0.7189269767 0.847528714 14 90404168 90404378 211 + 0.896 0.961 0.244
ENSG00000198668 E026 674.4323749 0.0002676810 0.0001992603 0.002667217 14 90404379 90404398 20 + 2.830 2.797 -0.110
ENSG00000198668 E027 1092.4694070 0.0003793826 0.0151578556 0.078674547 14 90404399 90404514 116 + 3.029 3.022 -0.026
ENSG00000198668 E028 3743.1002831 0.0105817982 0.3012380113 0.541702921 14 90404689 90408268 3580 + 3.539 3.588 0.163