ENSG00000198663

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355190 ENSG00000198663 HEK293_OSMI2_6hA HEK293_TMG_6hB C6orf89 protein_coding protein_coding 22.94824 22.20524 25.33995 1.999922 0.1763578 0.1904333 5.387539 3.585490 7.7983373 0.69126016 0.6007255 1.1188269 0.22773750 0.1593333 0.30750000 0.14816667 0.01762734 0.01762734 FALSE TRUE
ENST00000480824 ENSG00000198663 HEK293_OSMI2_6hA HEK293_TMG_6hB C6orf89 protein_coding protein_coding 22.94824 22.20524 25.33995 1.999922 0.1763578 0.1904333 12.682443 11.405006 14.3482844 0.86980557 0.2278503 0.3309518 0.55013750 0.5150000 0.56616667 0.05116667 0.51925162 0.01762734 FALSE TRUE
MSTRG.28218.8 ENSG00000198663 HEK293_OSMI2_6hA HEK293_TMG_6hB C6orf89 protein_coding   22.94824 22.20524 25.33995 1.999922 0.1763578 0.1904333 2.698791 4.787574 0.5906878 0.97043285 0.5906878 -2.9976178 0.12447917 0.2123667 0.02356667 -0.18880000 0.11088194 0.01762734 TRUE TRUE
MSTRG.28218.9 ENSG00000198663 HEK293_OSMI2_6hA HEK293_TMG_6hB C6orf89 protein_coding   22.94824 22.20524 25.33995 1.999922 0.1763578 0.1904333 1.294208 1.650175 1.3973167 0.04321919 0.2954741 -0.2383882 0.05892917 0.0760000 0.05523333 -0.02076667 0.74565675 0.01762734 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198663 E001 0.0000000       6 36871870 36871967 98 +      
ENSG00000198663 E002 3.1082761 0.1188417253 7.427179e-01 8.621071e-01 6 36879008 36879132 125 + 0.648 0.573 -0.333
ENSG00000198663 E003 2.8971560 0.0084915005 7.868685e-01 8.886756e-01 6 36883188 36883352 165 + 0.608 0.575 -0.146
ENSG00000198663 E004 1.5878616 0.4724704274 6.889984e-01 8.284440e-01 6 36885864 36885927 64 + 0.431 0.426 -0.029
ENSG00000198663 E005 5.2917318 0.0577698989 3.184497e-01 5.583237e-01 6 36885928 36885951 24 + 0.875 0.720 -0.615
ENSG00000198663 E006 80.3850487 0.0006495892 9.916099e-01 9.975701e-01 6 36885952 36886028 77 + 1.896 1.910 0.047
ENSG00000198663 E007 0.4576437 0.1568554577 5.368315e-01   6 36892766 36892856 91 + 0.223 0.117 -1.123
ENSG00000198663 E008 34.2248005 0.0222093426 8.692650e-01 9.355032e-01 6 36894504 36894603 100 + 1.527 1.560 0.113
ENSG00000198663 E009 198.3407309 0.0002761552 7.819237e-03 4.847893e-02 6 36899426 36899633 208 + 2.322 2.267 -0.183
ENSG00000198663 E010 121.8227103 0.0003912966 1.786099e-03 1.560613e-02 6 36902221 36902279 59 + 2.129 2.041 -0.297
ENSG00000198663 E011 216.2894876 0.0002640446 7.998902e-04 8.281397e-03 6 36902280 36902434 155 + 2.367 2.299 -0.229
ENSG00000198663 E012 201.2420899 0.0002602284 3.672113e-02 1.461651e-01 6 36914284 36914435 152 + 2.321 2.281 -0.133
ENSG00000198663 E013 200.7020358 0.0003074913 5.997978e-01 7.700873e-01 6 36914554 36914693 140 + 2.300 2.299 -0.003
ENSG00000198663 E014 210.8389355 0.0002249994 5.054625e-01 7.045988e-01 6 36916445 36916574 130 + 2.321 2.318 -0.012
ENSG00000198663 E015 225.2014687 0.0002236146 5.491990e-01 7.357791e-01 6 36919578 36919701 124 + 2.347 2.346 -0.005
ENSG00000198663 E016 749.9315561 0.0001105946 4.782426e-01 6.859393e-01 6 36923347 36924508 1162 + 2.858 2.880 0.073
ENSG00000198663 E017 133.5275493 0.0003235851 1.015795e-03 1.002867e-02 6 36924509 36924693 185 + 2.166 2.077 -0.298
ENSG00000198663 E018 52.1713789 0.0007731712 1.402882e-02 7.445518e-02 6 36924694 36924697 4 + 1.771 1.662 -0.370
ENSG00000198663 E019 89.7772286 0.0005517323 5.955081e-03 3.951818e-02 6 36924698 36924771 74 + 1.996 1.903 -0.311
ENSG00000198663 E020 1808.7646072 0.0007276186 1.001960e-06 2.846366e-05 6 36924772 36928964 4193 + 3.217 3.285 0.224