ENSG00000198551

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361113 ENSG00000198551 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF627 protein_coding protein_coding 6.688065 3.940938 7.449271 1.031231 0.1367162 0.9168395 2.9807230 0.6877953 5.5887711 0.004692859 0.21416142 3.0042344 0.4108250 0.1963000 0.75090000 0.5546000 2.040262e-07 2.040262e-07 FALSE TRUE
ENST00000593279 ENSG00000198551 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF627 protein_coding processed_transcript 6.688065 3.940938 7.449271 1.031231 0.1367162 0.9168395 0.9641825 0.8471791 0.4335213 0.095542559 0.02933935 -0.9505932 0.1555583 0.2408667 0.05810000 -0.1827667 1.325725e-02 2.040262e-07   FALSE
MSTRG.16476.2 ENSG00000198551 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF627 protein_coding   6.688065 3.940938 7.449271 1.031231 0.1367162 0.9168395 1.1001281 0.7023203 0.2901344 0.299956644 0.17204716 -1.2469176 0.1754250 0.1648000 0.03983333 -0.1249667 1.250460e-01 2.040262e-07   FALSE
MSTRG.16476.5 ENSG00000198551 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF627 protein_coding   6.688065 3.940938 7.449271 1.031231 0.1367162 0.9168395 1.3244706 1.6312124 0.9103307 0.715797618 0.35643742 -0.8345377 0.2076958 0.3807000 0.12106667 -0.2596333 1.140863e-01 2.040262e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198551 E001 0.6789713 0.043486100 3.893426e-02   19 11559374 11559377 4 + 0.079 0.409 2.965
ENSG00000198551 E002 0.6789713 0.043486100 3.893426e-02   19 11559378 11559402 25 + 0.079 0.409 2.965
ENSG00000198551 E003 2.8451530 0.009215811 1.108356e-05 2.293462e-04 19 11559403 11559447 45 + 0.256 0.890 3.074
ENSG00000198551 E004 4.1661461 0.006982792 1.292582e-07 4.679391e-06 19 11559448 11559460 13 + 0.343 1.036 3.037
ENSG00000198551 E005 6.4286547 0.004932846 1.290675e-09 7.397447e-08 19 11559461 11559500 40 + 0.506 1.192 2.722
ENSG00000198551 E006 10.5505317 0.003108826 1.832081e-16 3.385523e-14 19 11559501 11559616 116 + 0.644 1.414 2.871
ENSG00000198551 E007 0.5059767 0.021684047 7.466309e-03   19 11562126 11562224 99 + 0.000 0.408 11.051
ENSG00000198551 E008 5.2941351 0.006117346 1.751478e-09 9.768185e-08 19 11564061 11564184 124 + 0.416 1.145 3.016
ENSG00000198551 E009 3.8813796 0.009053399 4.786769e-08 1.915870e-06 19 11564445 11564492 48 + 0.301 1.036 3.300
ENSG00000198551 E010 7.0527057 0.004449454 1.790847e-11 1.476345e-09 19 11575250 11575353 104 + 0.532 1.258 2.831
ENSG00000198551 E011 0.6486114 0.019313711 3.671119e-02   19 11575354 11575567 214 + 0.079 0.408 2.960
ENSG00000198551 E012 6.6627963 0.013899749 1.219575e-11 1.036077e-09 19 11583417 11583630 214 + 0.448 1.256 3.240
ENSG00000198551 E013 1.1964248 0.018925412 4.308787e-01   19 11597442 11597461 20 + 0.301 0.408 0.638
ENSG00000198551 E014 2.7785570 0.014690211 1.982237e-01 4.273737e-01 19 11597462 11597482 21 + 0.505 0.666 0.722
ENSG00000198551 E015 20.0094371 0.040503822 2.372819e-01 4.734181e-01 19 11597483 11597630 148 + 1.262 1.354 0.321
ENSG00000198551 E016 4.1974676 0.267303969 3.254233e-02 1.348233e-01 19 11598868 11599000 133 + 0.455 1.002 2.290
ENSG00000198551 E017 0.3337900 0.027273463 4.145989e-01   19 11602271 11602330 60 + 0.079 0.182 1.374
ENSG00000198551 E018 2.1042675 0.031933514 4.443150e-01 6.616298e-01 19 11604210 11604364 155 + 0.505 0.310 -1.079
ENSG00000198551 E019 20.4971342 0.002248201 4.643075e-03 3.270160e-02 19 11614527 11614653 127 + 1.366 1.036 -1.172
ENSG00000198551 E020 16.0742842 0.002147552 2.969683e-03 2.321361e-02 19 11614827 11614887 61 + 1.270 0.889 -1.386
ENSG00000198551 E021 12.3428058 0.003510716 4.388424e-03 3.131193e-02 19 11616695 11616705 11 + 1.165 0.754 -1.545
ENSG00000198551 E022 185.7076011 0.008581322 1.365637e-26 8.223991e-24 19 11616706 11619161 2456 + 2.312 1.878 -1.452