ENSG00000198498

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358572 ENSG00000198498 HEK293_OSMI2_6hA HEK293_TMG_6hB TMA16 protein_coding protein_coding 27.1066 16.36224 38.2311 5.112882 1.667414 1.223873 11.743678 6.9165210 16.5274622 1.9600928 0.65538179 1.255535 0.44200417 0.43743333 0.43290000 -0.004533333 1.000000e+00 4.371897e-08 FALSE TRUE
ENST00000508268 ENSG00000198498 HEK293_OSMI2_6hA HEK293_TMG_6hB TMA16 protein_coding protein_coding 27.1066 16.36224 38.2311 5.112882 1.667414 1.223873 2.475692 3.0262014 1.4177112 2.2180567 1.15033167 -1.088563 0.12471250 0.15936667 0.03630000 -0.123066667 8.155904e-01 4.371897e-08 FALSE TRUE
ENST00000509657 ENSG00000198498 HEK293_OSMI2_6hA HEK293_TMG_6hB TMA16 protein_coding protein_coding 27.1066 16.36224 38.2311 5.112882 1.667414 1.223873 1.699090 0.3603383 4.1821217 0.3603383 0.70090969 3.500765 0.05045000 0.04093333 0.10853333 0.067600000 3.175146e-01 4.371897e-08 FALSE TRUE
ENST00000511562 ENSG00000198498 HEK293_OSMI2_6hA HEK293_TMG_6hB TMA16 protein_coding processed_transcript 27.1066 16.36224 38.2311 5.112882 1.667414 1.223873 2.009474 2.3044271 0.9894195 0.8736789 0.05860739 -1.211493 0.07360833 0.13323333 0.02603333 -0.107200000 4.371897e-08 4.371897e-08   FALSE
ENST00000513272 ENSG00000198498 HEK293_OSMI2_6hA HEK293_TMG_6hB TMA16 protein_coding protein_coding 27.1066 16.36224 38.2311 5.112882 1.667414 1.223873 8.271964 3.4745959 13.2848243 1.2793557 0.32359517 1.931801 0.27697917 0.20810000 0.34846667 0.140366667 1.132870e-02 4.371897e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198498 E001 1.7668932 0.0585086479 6.871057e-01 8.272314e-01 4 163494442 163494559 118 + 0.458 0.368 -0.491
ENSG00000198498 E002 4.4100178 0.0064278401 8.539747e-01 9.270890e-01 4 163494659 163494666 8 + 0.719 0.734 0.063
ENSG00000198498 E003 4.4100178 0.0064278401 8.539747e-01 9.270890e-01 4 163494667 163494667 1 + 0.719 0.734 0.063
ENSG00000198498 E004 26.8987894 0.0013997237 7.941972e-01 8.928495e-01 4 163494668 163494687 20 + 1.433 1.439 0.021
ENSG00000198498 E005 26.7619518 0.0014296035 9.996761e-01 1.000000e+00 4 163494688 163494689 2 + 1.437 1.425 -0.041
ENSG00000198498 E006 62.3198643 0.0026511659 6.181987e-01 7.825489e-01 4 163494690 163494707 18 + 1.785 1.801 0.054
ENSG00000198498 E007 127.1204843 0.0006418126 1.086009e-04 1.601366e-03 4 163494708 163494804 97 + 2.055 2.168 0.378
ENSG00000198498 E008 4.9451867 0.0052587666 3.768126e-01 6.096915e-01 4 163494805 163494836 32 + 0.719 0.829 0.440
ENSG00000198498 E009 186.5929231 0.0003932116 5.178995e-03 3.556028e-02 4 163507033 163507145 113 + 2.240 2.301 0.203
ENSG00000198498 E010 1.2742079 0.1593970686 7.185967e-01   4 163512424 163512821 398 + 0.335 0.432 0.553
ENSG00000198498 E011 120.6523867 0.0005483760 8.434731e-02 2.534389e-01 4 163512822 163512859 38 + 2.058 2.104 0.153
ENSG00000198498 E012 164.0511375 0.0003493326 8.695281e-02 2.581571e-01 4 163514074 163514158 85 + 2.193 2.228 0.118
ENSG00000198498 E013 194.0013656 0.0003160129 1.363745e-03 1.263902e-02 4 163515313 163515461 149 + 2.251 2.318 0.225
ENSG00000198498 E014 9.3558040 0.0656000448 7.389626e-02 2.325564e-01 4 163515462 163516102 641 + 1.083 0.740 -1.303
ENSG00000198498 E015 3.2591314 0.0081596668 1.914577e-03 1.650453e-02 4 163517072 163517433 362 + 0.738 0.159 -3.338
ENSG00000198498 E016 147.8533980 0.0005252402 9.212791e-02 2.676584e-01 4 163517434 163517476 43 + 2.179 2.114 -0.217
ENSG00000198498 E017 0.8383617 0.0203303990 7.736221e-01   4 163517477 163517559 83 + 0.232 0.276 0.330
ENSG00000198498 E018 374.3277670 0.0014622253 2.754905e-07 9.159089e-06 4 163519334 163519981 648 + 2.601 2.461 -0.466
ENSG00000198498 E019 105.3971988 0.0133492598 1.675836e-01 3.873629e-01 4 163519982 163520539 558 + 2.044 1.928 -0.391