ENSG00000198453

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333987 ENSG00000198453 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF568 protein_coding protein_coding 1.363926 0.6635059 2.718501 0.03562214 0.1509923 2.018346 0.49098160 0.16694592 1.25661529 0.08369460 0.08354978 2.839598 0.30683750 0.2550000 0.464800000 0.20980000 0.65013866 0.01738284 FALSE TRUE
ENST00000415168 ENSG00000198453 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF568 protein_coding protein_coding 1.363926 0.6635059 2.718501 0.03562214 0.1509923 2.018346 0.08827372 0.08445674 0.02194611 0.06257192 0.02194611 -1.564014 0.08319583 0.1251333 0.008333333 -0.11680000 0.44030487 0.01738284 FALSE TRUE
ENST00000427117 ENSG00000198453 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF568 protein_coding protein_coding 1.363926 0.6635059 2.718501 0.03562214 0.1509923 2.018346 0.32450984 0.30496643 0.43155558 0.02786289 0.06372246 0.487397 0.29897083 0.4636333 0.158000000 -0.30563333 0.01738284 0.01738284 FALSE TRUE
ENST00000444991 ENSG00000198453 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF568 protein_coding protein_coding 1.363926 0.6635059 2.718501 0.03562214 0.1509923 2.018346 0.13516950 0.10713678 0.27969537 0.03840902 0.14302970 1.306343 0.09249167 0.1562000 0.109133333 -0.04706667 0.87426431 0.01738284 FALSE TRUE
ENST00000587130 ENSG00000198453 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF568 protein_coding protein_coding 1.363926 0.6635059 2.718501 0.03562214 0.1509923 2.018346 0.14993358 0.00000000 0.38407695 0.00000000 0.10744415 5.300405 0.09897917 0.0000000 0.139200000 0.13920000 0.03981955 0.01738284   FALSE
ENST00000617745 ENSG00000198453 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF568 protein_coding protein_coding 1.363926 0.6635059 2.718501 0.03562214 0.1509923 2.018346 0.03059452 0.00000000 0.17463587 0.00000000 0.17463587 4.206611 0.01268333 0.0000000 0.057966667 0.05796667 1.00000000 0.01738284 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198453 E001 0.1308682 0.0326491905 1.624783e-01   19 36916329 36916331 3 + 0.000 0.188 10.938
ENSG00000198453 E002 0.7201878 0.0454747703 7.800823e-01   19 36916332 36916340 9 + 0.246 0.188 -0.495
ENSG00000198453 E003 0.8981716 0.0170238248 5.963754e-01   19 36916341 36916342 2 + 0.292 0.188 -0.819
ENSG00000198453 E004 4.0473610 0.0527491437 4.145393e-01 0.6394841957 19 36916343 36916363 21 + 0.702 0.565 -0.597
ENSG00000198453 E005 10.2594082 0.0039160179 3.132131e-01 0.5534538238 19 36916364 36916448 85 + 0.966 1.074 0.398
ENSG00000198453 E006 7.9167497 0.0072284890 4.240628e-01 0.6465583594 19 36916449 36916454 6 + 0.865 0.962 0.366
ENSG00000198453 E007 14.7445866 0.0024678223 6.236525e-01 0.7863659008 19 36916455 36916591 137 + 1.135 1.180 0.159
ENSG00000198453 E008 9.1533595 0.0150592742 5.837857e-01 0.7594741789 19 36917579 36917648 70 + 0.946 1.010 0.236
ENSG00000198453 E009 0.0000000       19 36922562 36922570 9 +      
ENSG00000198453 E010 0.0000000       19 36922571 36922585 15 +      
ENSG00000198453 E011 15.3593470 0.0038043579 8.512962e-01 0.9257317153 19 36922586 36922846 261 + 1.164 1.179 0.055
ENSG00000198453 E012 10.1564675 0.0033008612 9.230444e-01 0.9638125990 19 36925200 36925258 59 + 1.000 1.010 0.035
ENSG00000198453 E013 0.6081007 0.0217567627 2.657648e-01   19 36931553 36931645 93 + 0.247 0.000 -13.570
ENSG00000198453 E014 18.4312141 0.0023994570 1.433095e-03 0.0131375191 19 36936746 36936872 127 + 1.153 1.406 0.887
ENSG00000198453 E015 16.5826302 0.0026436940 2.521984e-02 0.1128790683 19 36937147 36937242 96 + 1.135 1.324 0.669
ENSG00000198453 E016 58.5249235 0.0009184606 2.346174e-06 0.0000600142 19 36949512 36952743 3232 + 1.774 1.540 -0.795
ENSG00000198453 E017 0.0000000       19 36973213 36973214 2 +      
ENSG00000198453 E018 0.0000000       19 36973215 36973217 3 +      
ENSG00000198453 E019 0.0000000       19 36973218 36973410 193 +      
ENSG00000198453 E020 0.0000000       19 36973411 36973537 127 +      
ENSG00000198453 E021 0.0000000       19 36973538 36973560 23 +      
ENSG00000198453 E022 0.0000000       19 36973561 36973753 193 +      
ENSG00000198453 E023 4.2249965 0.0069709657 4.937493e-03 0.0342986823 19 36974420 36974466 47 + 0.543 0.934 1.611
ENSG00000198453 E024 0.0000000       19 36976327 36976367 41 +      
ENSG00000198453 E025 8.2376030 0.0049623458 8.321352e-02 0.2512011085 19 36979004 36980317 1314 + 0.853 1.054 0.750
ENSG00000198453 E026 0.0000000       19 36991053 36991175 123 +      
ENSG00000198453 E027 3.3582682 0.0114734668 4.546874e-01 0.6692760190 19 36991176 36991299 124 + 0.629 0.501 -0.587
ENSG00000198453 E028 0.2852693 0.2659359712 8.020871e-01   19 36991300 36991750 451 + 0.139 0.000 -12.254
ENSG00000198453 E029 2.3984043 0.0094214635 5.384738e-02 0.1887241751 19 36991751 36991846 96 + 0.566 0.188 -2.306
ENSG00000198453 E030 16.9920925 0.0024399992 6.132063e-02 0.2057675133 19 36996317 36998700 2384 + 1.252 1.074 -0.635