ENSG00000198399

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361999 ENSG00000198399 HEK293_OSMI2_6hA HEK293_TMG_6hB ITSN2 protein_coding protein_coding 6.075079 3.336857 11.18961 0.1181841 0.5770075 1.742569 1.8145028 1.2122217 2.8442219 0.2154657 0.40278817 1.2235915 0.34277083 0.35976667 0.25340000 -0.10636667 0.62576720 0.01471116 FALSE TRUE
ENST00000416160 ENSG00000198399 HEK293_OSMI2_6hA HEK293_TMG_6hB ITSN2 protein_coding protein_coding 6.075079 3.336857 11.18961 0.1181841 0.5770075 1.742569 1.1487556 0.3053572 2.2243098 0.1697054 0.52062478 2.8247703 0.18194167 0.09276667 0.19616667 0.10340000 0.68450862 0.01471116 FALSE FALSE
ENST00000478720 ENSG00000198399 HEK293_OSMI2_6hA HEK293_TMG_6hB ITSN2 protein_coding retained_intron 6.075079 3.336857 11.18961 0.1181841 0.5770075 1.742569 0.2067475 0.3312554 0.1479021 0.1050484 0.03657573 -1.1118219 0.06455833 0.10183333 0.01363333 -0.08820000 0.01471116 0.01471116   FALSE
ENST00000479575 ENSG00000198399 HEK293_OSMI2_6hA HEK293_TMG_6hB ITSN2 protein_coding retained_intron 6.075079 3.336857 11.18961 0.1181841 0.5770075 1.742569 0.1216138 0.3395086 0.1809640 0.1737146 0.06092924 -0.8720267 0.03021250 0.10393333 0.01680000 -0.08713333 0.55005160 0.01471116 FALSE FALSE
MSTRG.18048.13 ENSG00000198399 HEK293_OSMI2_6hA HEK293_TMG_6hB ITSN2 protein_coding   6.075079 3.336857 11.18961 0.1181841 0.5770075 1.742569 0.5083679 0.2034553 0.8954371 0.2034553 0.55605977 2.0846807 0.06688333 0.05816667 0.08496667 0.02680000 0.84887044 0.01471116 FALSE TRUE
MSTRG.18048.18 ENSG00000198399 HEK293_OSMI2_6hA HEK293_TMG_6hB ITSN2 protein_coding   6.075079 3.336857 11.18961 0.1181841 0.5770075 1.742569 1.4464836 0.1312999 3.5590162 0.1312999 0.34054418 4.6586939 0.14982500 0.04226667 0.31683333 0.27456667 0.11433568 0.01471116 FALSE TRUE
MSTRG.18048.7 ENSG00000198399 HEK293_OSMI2_6hA HEK293_TMG_6hB ITSN2 protein_coding   6.075079 3.336857 11.18961 0.1181841 0.5770075 1.742569 0.2701624 0.7682152 0.5728430 0.1419129 0.29197032 -0.4170619 0.07586667 0.22800000 0.05193333 -0.17606667 0.42203597 0.01471116 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198399 E001 13.0310737 0.0687512926 4.644409e-02 1.711240e-01 2 24202864 24203058 195 - 0.976 1.308 1.192
ENSG00000198399 E002 31.6566679 0.0130619483 4.318945e-06 1.014182e-04 2 24203059 24203281 223 - 1.319 1.705 1.324
ENSG00000198399 E003 25.5208060 0.0015120143 1.068104e-07 3.932120e-06 2 24203282 24203413 132 - 1.230 1.618 1.343
ENSG00000198399 E004 18.8476530 0.0017849124 3.414618e-03 2.584830e-02 2 24203414 24203541 128 - 1.161 1.418 0.899
ENSG00000198399 E005 13.3629232 0.0054776213 1.496630e-01 3.617813e-01 2 24203542 24203592 51 - 1.052 1.213 0.579
ENSG00000198399 E006 24.8368835 0.0021819182 2.279753e-04 2.979257e-03 2 24203593 24203783 191 - 1.263 1.550 0.992
ENSG00000198399 E007 2.7860489 0.0079414437 2.391815e-02 1.088385e-01 2 24203784 24204244 461 - 0.402 0.773 1.696
ENSG00000198399 E008 23.7003397 0.0015365576 1.699035e-04 2.333673e-03 2 24204245 24204362 118 - 1.244 1.536 1.013
ENSG00000198399 E009 17.0497855 0.0083593035 2.583557e-04 3.306961e-03 2 24204363 24204418 56 - 1.086 1.436 1.232
ENSG00000198399 E010 16.2355067 0.0078075970 1.580281e-03 1.417911e-02 2 24205214 24205265 52 - 1.079 1.390 1.098
ENSG00000198399 E011 13.8477369 0.0027771519 7.771622e-03 4.823831e-02 2 24205266 24205297 32 - 1.037 1.304 0.952
ENSG00000198399 E012 3.6854261 0.3776517463 6.898186e-02 2.227338e-01 2 24205298 24205693 396 - 0.376 0.970 2.600
ENSG00000198399 E013 0.8978411 0.2896998401 4.442024e-02   2 24206244 24206275 32 - 0.076 0.513 3.557
ENSG00000198399 E014 18.5958472 0.0166875838 5.937183e-02 2.013922e-01 2 24208237 24208319 83 - 1.179 1.386 0.726
ENSG00000198399 E015 27.3326868 0.0023992994 8.713704e-05 1.331715e-03 2 24209100 24209221 122 - 1.302 1.594 1.009
ENSG00000198399 E016 30.9973572 0.0054480285 1.254667e-06 3.458389e-05 2 24209818 24210033 216 - 1.329 1.686 1.228
ENSG00000198399 E017 2.4316900 0.0618558145 1.785751e-02 8.855899e-02 2 24210034 24210329 296 - 0.332 0.771 2.093
ENSG00000198399 E018 19.5887649 0.4552321026 6.097012e-02 2.049592e-01 2 24210780 24210947 168 - 1.062 1.571 1.783
ENSG00000198399 E019 12.9251384 0.3426684026 4.370686e-02 1.643804e-01 2 24212650 24212748 99 - 0.905 1.395 1.760
ENSG00000198399 E020 17.9265231 0.5462282513 1.967024e-01 4.254084e-01 2 24216049 24216232 184 - 1.100 1.460 1.263
ENSG00000198399 E021 15.9509492 0.5814211623 3.233633e-01 5.627007e-01 2 24217907 24218013 107 - 1.088 1.366 0.982
ENSG00000198399 E022 0.3751086 0.0271683931 4.023483e-02   2 24220319 24220944 626 - 0.000 0.322 13.468
ENSG00000198399 E023 22.7101629 0.0959235642 2.135892e-01 4.458802e-01 2 24220945 24221066 122 - 1.268 1.459 0.662
ENSG00000198399 E024 134.4260906 0.0111591697 4.332247e-05 7.368205e-04 2 24238933 24241963 3031 - 2.126 1.898 -0.766
ENSG00000198399 E025 3.0961772 0.0757778884 3.083553e-02 1.298540e-01 2 24241964 24241964 1 - 0.659 0.190 -2.694
ENSG00000198399 E026 5.0021362 0.0388599599 9.075362e-03 5.415909e-02 2 24241965 24242007 43 - 0.823 0.322 -2.364
ENSG00000198399 E027 4.6095814 0.0061196565 7.497075e-03 4.701536e-02 2 24242008 24242065 58 - 0.788 0.321 -2.228
ENSG00000198399 E028 18.8387574 0.0022015241 1.268692e-04 1.822168e-03 2 24242066 24242206 141 - 1.318 0.938 -1.368
ENSG00000198399 E029 55.7920892 0.0032440405 9.255102e-01 9.649064e-01 2 24246129 24246320 192 - 1.700 1.710 0.035
ENSG00000198399 E030 32.1688992 0.0077846128 5.182898e-01 7.138667e-01 2 24246797 24246893 97 - 1.448 1.514 0.228
ENSG00000198399 E031 29.4900138 0.0130068526 7.582084e-01 8.714922e-01 2 24248629 24248750 122 - 1.419 1.466 0.162
ENSG00000198399 E032 29.8196248 0.0301428707 8.648694e-01 9.330652e-01 2 24248837 24248882 46 - 1.433 1.440 0.022
ENSG00000198399 E033 54.7670885 0.0007695979 8.511435e-01 9.256724e-01 2 24252345 24252511 167 - 1.683 1.711 0.094
ENSG00000198399 E034 38.2948436 0.0087864423 9.309785e-01 9.675032e-01 2 24254367 24254431 65 - 1.529 1.552 0.076
ENSG00000198399 E035 56.6786053 0.0094586343 9.063551e-01 9.552690e-01 2 24257888 24258093 206 - 1.695 1.720 0.083
ENSG00000198399 E036 48.3676104 0.0033834195 4.463452e-01 6.629671e-01 2 24261106 24261250 145 - 1.644 1.613 -0.104
ENSG00000198399 E037 43.4307694 0.0009121975 8.384261e-01 9.185615e-01 2 24261561 24261742 182 - 1.583 1.612 0.100
ENSG00000198399 E038 34.3295486 0.0011309794 5.869782e-02 1.998640e-01 2 24270671 24270768 98 - 1.523 1.409 -0.393
ENSG00000198399 E039 15.9927789 0.0019531877 4.657408e-02 1.714913e-01 2 24271766 24271804 39 - 1.220 1.035 -0.663
ENSG00000198399 E040 43.9160481 0.0008239287 3.691805e-02 1.467184e-01 2 24271805 24271941 137 - 1.626 1.515 -0.379
ENSG00000198399 E041 41.4884881 0.0014963524 2.283837e-02 1.054441e-01 2 24275713 24275849 137 - 1.608 1.477 -0.447
ENSG00000198399 E042 0.0000000       2 24284763 24284843 81 -      
ENSG00000198399 E043 33.8452093 0.0012933441 6.485195e-02 2.135744e-01 2 24286212 24286322 111 - 1.513 1.400 -0.390
ENSG00000198399 E044 21.2382255 0.0021634636 4.624896e-01 6.748315e-01 2 24286323 24286351 29 - 1.301 1.255 -0.163
ENSG00000198399 E045 0.0000000       2 24293261 24293687 427 -      
ENSG00000198399 E046 27.0511692 0.0016810922 5.601606e-01 7.434603e-01 2 24293688 24293775 88 - 1.397 1.370 -0.095
ENSG00000198399 E047 36.5418524 0.0014674841 2.144923e-01 4.469196e-01 2 24295664 24295804 141 - 1.535 1.469 -0.227
ENSG00000198399 E048 0.1779838 0.0366807432 1.000000e+00   2 24296852 24296917 66 - 0.076 0.000 -9.451
ENSG00000198399 E049 37.4544201 0.0010289101 2.992029e-02 1.270988e-01 2 24298665 24298814 150 - 1.563 1.435 -0.438
ENSG00000198399 E050 58.1769911 0.0019600233 1.808047e-02 8.930418e-02 2 24299909 24300171 263 - 1.748 1.634 -0.388
ENSG00000198399 E051 31.4925244 0.0025153730 4.983077e-03 3.453341e-02 2 24301154 24301239 86 - 1.503 1.304 -0.688
ENSG00000198399 E052 36.6310873 0.0173744417 2.890601e-02 1.240845e-01 2 24301965 24302102 138 - 1.566 1.378 -0.649
ENSG00000198399 E053 25.8466110 0.0065536803 1.949260e-03 1.672710e-02 2 24303799 24303862 64 - 1.434 1.166 -0.938
ENSG00000198399 E054 38.0047990 0.0083622315 4.376019e-03 3.123917e-02 2 24308617 24308756 140 - 1.584 1.370 -0.735
ENSG00000198399 E055 0.0000000       2 24308878 24308952 75 -      
ENSG00000198399 E056 26.6088338 0.0013241251 4.584401e-04 5.299052e-03 2 24310284 24310343 60 - 1.444 1.167 -0.971
ENSG00000198399 E057 24.9607683 0.0014827075 4.430265e-03 3.154553e-02 2 24310344 24310380 37 - 1.407 1.183 -0.786
ENSG00000198399 E058 41.6161758 0.0097345374 1.212404e-02 6.694656e-02 2 24310489 24310692 204 - 1.616 1.435 -0.618
ENSG00000198399 E059 0.0000000       2 24311620 24311662 43 -      
ENSG00000198399 E060 27.7073688 0.0155335075 8.582904e-03 5.196764e-02 2 24312212 24312375 164 - 1.459 1.211 -0.862
ENSG00000198399 E061 16.7007159 0.0100031615 2.664718e-01 5.059712e-01 2 24313460 24313523 64 - 1.225 1.130 -0.338
ENSG00000198399 E062 19.0607343 0.0020783706 2.836779e-01 5.241145e-01 2 24315132 24315224 93 - 1.276 1.197 -0.277
ENSG00000198399 E063 1.6510496 0.0176421883 2.013513e-01 4.313948e-01 2 24321814 24321880 67 - 0.433 0.190 -1.644
ENSG00000198399 E064 0.0000000       2 24326660 24326681 22 -      
ENSG00000198399 E065 10.5282128 0.0308721319 6.826809e-02 2.211950e-01 2 24328052 24328115 64 - 1.063 0.809 -0.954
ENSG00000198399 E066 0.2852693 0.2868406369 7.713487e-01   2 24359839 24359876 38 - 0.138 0.000 -10.425
ENSG00000198399 E067 9.3712559 0.0155342058 6.084641e-01 7.758816e-01 2 24360304 24360576 273 - 0.982 0.935 -0.174