ENSG00000198373

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359154 ENSG00000198373 HEK293_OSMI2_6hA HEK293_TMG_6hB WWP2 protein_coding protein_coding 13.42464 18.07598 9.03647 2.762247 0.1150582 -0.9994449 6.4980226 8.6146139 5.8072387 1.6447434 0.08169088 -0.56812536 0.50247500 0.47116667 0.64263333 0.171466667 2.676864e-02 3.041787e-15 FALSE TRUE
ENST00000569174 ENSG00000198373 HEK293_OSMI2_6hA HEK293_TMG_6hB WWP2 protein_coding protein_coding 13.42464 18.07598 9.03647 2.762247 0.1150582 -0.9994449 0.6542652 0.7948038 0.7810085 0.1045381 0.11949982 -0.02494379 0.05355417 0.04440000 0.08613333 0.041733333 2.096766e-01 3.041787e-15 FALSE TRUE
ENST00000569297 ENSG00000198373 HEK293_OSMI2_6hA HEK293_TMG_6hB WWP2 protein_coding processed_transcript 13.42464 18.07598 9.03647 2.762247 0.1150582 -0.9994449 1.5477525 2.6584192 0.0000000 0.5784024 0.00000000 -8.05984153 0.08262500 0.14346667 0.00000000 -0.143466667 3.041787e-15 3.041787e-15 FALSE TRUE
MSTRG.12892.1 ENSG00000198373 HEK293_OSMI2_6hA HEK293_TMG_6hB WWP2 protein_coding   13.42464 18.07598 9.03647 2.762247 0.1150582 -0.9994449 0.8948111 1.6438995 0.8100232 0.3294159 0.15942369 -1.01213501 0.06628750 0.09116667 0.08963333 -0.001533333 1.000000e+00 3.041787e-15 FALSE TRUE
MSTRG.12892.2 ENSG00000198373 HEK293_OSMI2_6hA HEK293_TMG_6hB WWP2 protein_coding   13.42464 18.07598 9.03647 2.762247 0.1150582 -0.9994449 2.2864451 3.7940112 1.1895904 0.8205493 0.20567925 -1.66497963 0.18394583 0.21363333 0.13186667 -0.081766667 5.507086e-01 3.041787e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198373 E001 0.2027342 0.0340801095 1.000000e+00   16 69762295 69762314 20 + 0.000 0.084 9.408
ENSG00000198373 E002 3.4807127 0.0071666036 2.089995e-01 4.406813e-01 16 69762315 69762327 13 + 0.470 0.684 0.974
ENSG00000198373 E003 4.5535736 0.0058482623 1.432915e-01 3.524243e-01 16 69762328 69762331 4 + 0.537 0.771 1.007
ENSG00000198373 E004 15.0899632 0.0025314686 7.908152e-01 8.909786e-01 16 69762332 69762361 30 + 1.181 1.160 -0.075
ENSG00000198373 E005 36.4448818 0.0010692094 4.218311e-01 6.450437e-01 16 69762362 69762391 30 + 1.570 1.524 -0.157
ENSG00000198373 E006 0.0000000       16 69774694 69774788 95 +      
ENSG00000198373 E007 0.0000000       16 69775079 69775140 62 +      
ENSG00000198373 E008 0.1614157 0.0332793356 2.115951e-01   16 69776187 69776188 2 + 0.173 0.000 -13.647
ENSG00000198373 E009 18.5329316 0.0020745201 8.797265e-01 9.410995e-01 16 69776189 69776241 53 + 1.245 1.262 0.057
ENSG00000198373 E010 12.0728405 0.0029182943 7.826228e-01 8.861924e-01 16 69783032 69783152 121 + 1.051 1.083 0.115
ENSG00000198373 E011 62.9710599 0.0006469287 6.527124e-01 8.052068e-01 16 69786996 69787080 85 + 1.753 1.779 0.086
ENSG00000198373 E012 0.1308682 0.0326491905 1.000000e+00   16 69787938 69788202 265 + 0.000 0.084 11.512
ENSG00000198373 E013 100.9585989 0.0003972025 4.316099e-02 1.629698e-01 16 69798682 69798829 148 + 2.021 1.950 -0.239
ENSG00000198373 E014 0.1779838 0.0339335372 2.116090e-01   16 69798865 69798954 90 + 0.173 0.000 -13.639
ENSG00000198373 E015 0.0000000       16 69799046 69799173 128 +      
ENSG00000198373 E016 96.1398119 0.0004706668 1.101214e-03 1.067721e-02 16 69799174 69799295 122 + 2.031 1.911 -0.404
ENSG00000198373 E017 0.0000000       16 69799296 69799493 198 +      
ENSG00000198373 E018 0.0000000       16 69827894 69828019 126 +      
ENSG00000198373 E019 0.0000000       16 69838737 69838889 153 +      
ENSG00000198373 E020 95.5783185 0.0007406835 4.585425e-04 5.299875e-03 16 69840126 69840263 138 + 2.033 1.899 -0.448
ENSG00000198373 E021 68.8488912 0.0030357260 5.558837e-02 1.926725e-01 16 69842024 69842120 97 + 1.867 1.771 -0.325
ENSG00000198373 E022 0.1614157 0.0332793356 2.115951e-01   16 69871713 69871803 91 + 0.173 0.000 -13.647
ENSG00000198373 E023 76.1920453 0.0005607916 1.386974e-01 3.455441e-01 16 69871804 69871931 128 + 1.893 1.832 -0.203
ENSG00000198373 E024 102.2159803 0.0005803314 1.513122e-01 3.642516e-01 16 69888039 69888249 211 + 2.011 1.961 -0.168
ENSG00000198373 E025 0.0000000       16 69890798 69890879 82 +      
ENSG00000198373 E026 0.0000000       16 69894962 69895149 188 +      
ENSG00000198373 E027 66.5013859 0.0006300825 9.805829e-02 2.783591e-01 16 69908761 69908850 90 + 1.844 1.772 -0.242
ENSG00000198373 E028 30.6320655 0.0012806207 5.676966e-04 6.288842e-03 16 69908851 69910250 1400 + 1.608 1.388 -0.753
ENSG00000198373 E029 0.4646582 0.0217681645 9.062952e-01   16 69917583 69917708 126 + 0.173 0.154 -0.195
ENSG00000198373 E030 85.0018531 0.0005379500 1.694511e-01 3.898435e-01 16 69917709 69917883 175 + 1.934 1.881 -0.178
ENSG00000198373 E031 0.1723744 0.0410232926 1.000000e+00   16 69924990 69925011 22 + 0.000 0.084 11.439
ENSG00000198373 E032 0.5530924 0.0253545802 9.112697e-01   16 69925012 69925429 418 + 0.173 0.155 -0.191
ENSG00000198373 E033 51.7524308 0.0007706366 2.531358e-01 4.913858e-01 16 69925430 69925484 55 + 1.726 1.670 -0.188
ENSG00000198373 E034 1.6719715 0.0114646601 5.213236e-01 7.157903e-01 16 69925980 69926096 117 + 0.470 0.358 -0.609
ENSG00000198373 E035 74.5604822 0.0005490570 1.653174e-01 3.843689e-01 16 69929448 69929529 82 + 1.882 1.825 -0.190
ENSG00000198373 E036 56.5930173 0.0007981262 5.567711e-02 1.928896e-01 16 69930130 69930165 36 + 1.786 1.694 -0.311
ENSG00000198373 E037 75.9794757 0.0050234626 5.198125e-01 7.148950e-01 16 69930166 69930258 93 + 1.817 1.855 0.128
ENSG00000198373 E038 72.3298735 0.0006217160 6.121205e-01 7.782730e-01 16 69931152 69931227 76 + 1.838 1.819 -0.065
ENSG00000198373 E039 78.6466162 0.0029492937 6.619471e-01 8.110901e-01 16 69931509 69931580 72 + 1.874 1.853 -0.071
ENSG00000198373 E040 3.1819773 0.0301851912 6.925084e-01 8.306882e-01 16 69931581 69931801 221 + 0.644 0.576 -0.300
ENSG00000198373 E041 75.0254353 0.0042077561 2.975817e-01 5.380715e-01 16 69931802 69931890 89 + 1.876 1.823 -0.178
ENSG00000198373 E042 64.9962818 0.0061384053 8.909029e-01 9.470988e-01 16 69933970 69934050 81 + 1.771 1.783 0.039
ENSG00000198373 E043 80.5456127 0.0038252038 3.077796e-01 5.484114e-01 16 69934051 69934129 79 + 1.908 1.861 -0.156
ENSG00000198373 E044 120.3273736 0.0003473110 4.098076e-02 1.572692e-01 16 69935853 69935986 134 + 2.093 2.027 -0.221
ENSG00000198373 E045 139.0089163 0.0008270221 2.322912e-01 4.678951e-01 16 69936312 69936452 141 + 2.136 2.099 -0.122
ENSG00000198373 E046 1.8977384 0.0117922421 6.916073e-01 8.301292e-01 16 69936453 69936796 344 + 0.392 0.465 0.389
ENSG00000198373 E047 0.5365243 0.0243684015 9.113319e-01   16 69936920 69937117 198 + 0.173 0.155 -0.190
ENSG00000198373 E048 115.6063265 0.0018491031 9.251794e-01 9.648407e-01 16 69937118 69937238 121 + 2.032 2.032 0.000
ENSG00000198373 E049 109.1675347 0.0056177100 7.944957e-01 8.930122e-01 16 69937548 69937652 105 + 1.994 2.011 0.057
ENSG00000198373 E050 104.6339715 0.0011286072 1.011157e-02 5.861521e-02 16 69939027 69939123 97 + 1.906 2.014 0.362
ENSG00000198373 E051 95.7736067 0.0004397283 3.426077e-01 5.802889e-01 16 69939341 69939413 73 + 1.919 1.960 0.138
ENSG00000198373 E052 637.2395380 0.0003354953 3.331958e-22 1.271558e-19 16 69939841 69941741 1901 + 2.652 2.809 0.525