ENSG00000198252

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354586 ENSG00000198252 HEK293_OSMI2_6hA HEK293_TMG_6hB STYX protein_coding protein_coding 9.531357 3.904673 16.62421 0.7441775 0.462769 2.087189 1.7544873 0.9670649 0.000000 0.2070127 0.00000000 -6.610383 0.16871667 0.24473333 0.0000000 -0.24473333 1.976236e-25 1.976236e-25 FALSE TRUE
ENST00000442123 ENSG00000198252 HEK293_OSMI2_6hA HEK293_TMG_6hB STYX protein_coding protein_coding 9.531357 3.904673 16.62421 0.7441775 0.462769 2.087189 1.6513945 0.0000000 6.476458 0.0000000 0.02325105 9.341287 0.14555000 0.00000000 0.3901333 0.39013333 9.483807e-24 1.976236e-25 FALSE TRUE
ENST00000556861 ENSG00000198252 HEK293_OSMI2_6hA HEK293_TMG_6hB STYX protein_coding processed_transcript 9.531357 3.904673 16.62421 0.7441775 0.462769 2.087189 0.3728441 0.1891945 0.000000 0.1891945 0.00000000 -4.316106 0.06664583 0.03976667 0.0000000 -0.03976667 6.942162e-01 1.976236e-25   FALSE
MSTRG.9549.1 ENSG00000198252 HEK293_OSMI2_6hA HEK293_TMG_6hB STYX protein_coding   9.531357 3.904673 16.62421 0.7441775 0.462769 2.087189 5.7526306 2.7484134 10.147747 0.4583520 0.44088478 1.880670 0.61909583 0.71553333 0.6098667 -0.10566667 4.738467e-01 1.976236e-25 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198252 E001 0.3559677 0.4603799862 1.000000e+00   14 52730165 52730165 1 + 0.124 0.000 -8.333
ENSG00000198252 E002 0.8192208 0.0660453969 3.223765e-01   14 52730166 52730179 14 + 0.257 0.000 -12.296
ENSG00000198252 E003 4.4014757 0.0062155421 5.280319e-01 7.206347e-01 14 52730180 52730210 31 + 0.642 0.742 0.416
ENSG00000198252 E004 45.6351479 0.0008998245 6.394595e-04 6.914800e-03 14 52730211 52730458 248 + 1.530 1.727 0.670
ENSG00000198252 E005 45.4900145 0.0008439380 9.165205e-02 2.667642e-01 14 52730459 52730531 73 + 1.552 1.653 0.343
ENSG00000198252 E006 0.2027342 0.0345702348 1.040085e-01   14 52731594 52731712 119 + 0.000 0.217 12.157
ENSG00000198252 E007 40.3802397 0.0011781748 8.916807e-01 9.474666e-01 14 52744852 52744884 33 + 1.523 1.531 0.025
ENSG00000198252 E008 44.0503471 0.0008499901 1.424086e-01 3.510460e-01 14 52746426 52746479 54 + 1.544 1.633 0.304
ENSG00000198252 E009 61.5628719 0.0023548537 5.887024e-02 2.002070e-01 14 52750683 52750780 98 + 1.685 1.789 0.352
ENSG00000198252 E010 41.9897075 0.0014141259 3.238095e-01 5.631252e-01 14 52756551 52756611 61 + 1.530 1.592 0.215
ENSG00000198252 E011 46.1210656 0.0082413595 9.924341e-01 9.979069e-01 14 52757319 52757355 37 + 1.586 1.584 -0.007
ENSG00000198252 E012 40.4284248 0.0046036103 8.936280e-01 9.484912e-01 14 52757743 52757782 40 + 1.524 1.531 0.025
ENSG00000198252 E013 46.1062640 0.0011198099 7.268166e-01 8.523232e-01 14 52757874 52757924 51 + 1.579 1.599 0.070
ENSG00000198252 E014 55.8116710 0.0008901532 9.372925e-01 9.708478e-01 14 52759682 52759754 73 + 1.664 1.658 -0.019
ENSG00000198252 E015 77.1249130 0.0007192039 2.110386e-01 4.430008e-01 14 52768840 52768933 94 + 1.787 1.846 0.196
ENSG00000198252 E016 76.4753496 0.0005133856 6.728516e-01 8.181332e-01 14 52771033 52771183 151 + 1.793 1.812 0.066
ENSG00000198252 E017 220.9615077 0.0004178485 3.642167e-11 2.823020e-09 14 52771184 52773615 2432 + 2.284 2.086 -0.665
ENSG00000198252 E018 126.8640836 0.0122452092 8.646148e-01 9.329327e-01 14 52773616 52774989 1374 + 2.014 2.012 -0.006
ENSG00000198252 E019 0.1614157 0.0359551000 1.000000e+00   14 52790517 52790561 45 + 0.065 0.000 -10.270