ENSG00000198242

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422514 ENSG00000198242 HEK293_OSMI2_6hA HEK293_TMG_6hB RPL23A protein_coding protein_coding 1040.838 1115.855 844.5259 299.6002 35.24971 -0.4019315 653.9003 705.1627 416.6258 194.1640 14.68814 -0.75918986 0.6019167 0.6263667 0.4936 -0.1327667 0.012272927 0.003977698 FALSE TRUE
ENST00000578181 ENSG00000198242 HEK293_OSMI2_6hA HEK293_TMG_6hB RPL23A protein_coding protein_coding 1040.838 1115.855 844.5259 299.6002 35.24971 -0.4019315 367.6366 393.9515 405.6335 108.6377 18.33750 0.04215771 0.3770500 0.3549333 0.4802 0.1252667 0.003977698 0.003977698 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198242 E001 15.075766 0.002118852 0.2929350448 0.533612667 17 28719985 28719990 6 + 1.197 1.194 -0.011
ENSG00000198242 E002 8835.664265 0.073445723 0.3103733736 0.550872028 17 28719991 28720030 40 + 3.892 3.936 0.147
ENSG00000198242 E003 22.754278 0.185843801 0.0499746644 0.179605157 17 28720079 28720213 135 + 1.534 1.218 -1.095
ENSG00000198242 E004 10.512408 0.217824144 0.0623221474 0.207997289 17 28720244 28720263 20 + 1.222 0.896 -1.191
ENSG00000198242 E005 20.340365 0.114497026 0.0467484995 0.171934670 17 28720264 28720298 35 + 1.454 1.204 -0.871
ENSG00000198242 E006 24.481385 0.091545911 0.0514497379 0.183172932 17 28720299 28720328 30 + 1.506 1.301 -0.709
ENSG00000198242 E007 33.341114 0.124333507 0.0977641148 0.277849103 17 28720329 28720413 85 + 1.624 1.440 -0.630
ENSG00000198242 E008 23.586365 0.129986470 0.0930376004 0.269354884 17 28720414 28720430 17 + 1.489 1.287 -0.701
ENSG00000198242 E009 8.643561 0.041433244 0.0001521201 0.002123765 17 28720550 28720568 19 + 1.198 0.755 -1.655
ENSG00000198242 E010 13.123444 0.051447356 0.0060393509 0.039918292 17 28720569 28720704 136 + 1.305 1.003 -1.081
ENSG00000198242 E011 9.378416 0.061527760 0.5331410735 0.724294175 17 28720705 28720706 2 + 1.013 0.991 -0.081
ENSG00000198242 E012 12158.186649 0.026751256 0.3029731149 0.543554726 17 28720707 28720890 184 + 4.011 4.084 0.243
ENSG00000198242 E013 75.133278 0.208056767 0.0353101641 0.142396951 17 28720891 28721261 371 + 2.057 1.705 -1.188
ENSG00000198242 E014 11336.478384 0.458405666 0.3307643490 0.569711881 17 28722723 28722899 177 + 3.920 4.077 0.520
ENSG00000198242 E015 37.733804 0.266540313 0.0985127500 0.279210433 17 28723300 28723428 129 + 1.745 1.431 -1.071
ENSG00000198242 E016 31.384744 0.201998247 0.0803638544 0.245571405 17 28723429 28723570 142 + 1.657 1.363 -1.010
ENSG00000198242 E017 6514.558178 0.201270539 0.3131237192 0.553367525 17 28723571 28723640 70 + 3.690 3.832 0.473
ENSG00000198242 E018 21.035313 0.231726911 0.0493590815 0.178056799 17 28723641 28723681 41 + 1.523 1.158 -1.273
ENSG00000198242 E019 29.312760 0.248451395 0.0583397689 0.199074783 17 28723682 28723800 119 + 1.670 1.288 -1.313
ENSG00000198242 E020 2328.293769 0.007404682 0.7685996139 0.877780042 17 28723867 28724359 493 + 3.253 3.383 0.431